anti-tuberculosis — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T38359	Dup-721		Antibacterial
	DuP-721 is a broad spectrum and orally active antibacterial agent. DuP-721 inhibits a variety of clinically susceptible and resistant bacteria, especially M. tuberculosis.		Antibacterial
T8694	ML406		Antibacterial , Antibiotic
	ML406 shows anti-tubercular activity via MtbbioA (DAPA synthase) enzyme inhibition(IC50 : 30 nM)		Antibacterial , Antibiotic
T3332	Isosteviol	(-)-Isosteviol	IL Receptor , Potassium Channel , TNF , NF-κB , Reactive Oxygen Species , COX , Topoisomerase
	Isosteviol ((-)-Isosteviol), a common natural sweetener, belongs to tetracyclic diterpene glycosides. The pharmacology researches have suggested that stevioside and its hydrolysis products, steviol, isosteviol and stevio...
T22365	Methyl α-D-mannopyranoside	Methyl α-D-mannopyranoside	Antibacterial
	Methyl α-D-mannopyranoside (Methyl α-D-mannopyranoside) can be used as an intermediate for chemical sythesis and can target macrophages in anti-tuberculosis inhalation therapy[1].		Antibacterial
T5400	Q203	IAP6,Telacebec	Antibacterial , Antibiotic
	Q203 (Telacebec) is a novel potent anti-tuberculosis agent targeting cytochrome b subunit qcrB and inhibits M. tuberculosis H37Rv (MIC50: 2.7 nM).		Antibacterial , Antibiotic
T3642	TBA-354	TBA 354	Antibacterial , Antibiotic
	TBA-354 is anti-tuberculous and active against Mycobacterium tuberculosis strain H37Rv.		Antibacterial , Antibiotic
T4531	GSK2200150A		Antibacterial
	GSK2200150A is an anti-tuberculosis (TB) agent identified by high-throughput screening (HTS) campaign.		Antibacterial
T10329	anti-TB agent 1		Antibiotic
	anti-TB agent 1 is a potent and orally active anti-tuberculosis agent (MICs: < 2 nM against the Mtb strains H37Rv, rRMP and rINH).		Antibiotic
T6096	Pretomanid	(S)-PA 824,PA-824	Antibacterial , Antibiotic
	Pretomanid ((S)-PA 824) , a nitroimidazole, is used as an anti-tuberculosis drug for tuberculosis with MIC less than 2.8 μM.		Antibacterial , Antibiotic
T2585	Bedaquiline	R207910,TMC207	Antibacterial , Antibiotic
	Bedaquiline (R207910)(TMC207; R207910) is an anti-tuberculosis drug which selectively inhibit the mycobacterial energy metabolism i.e. ATP synthesis and found to be effective against all states of Mycobacterium tuberculo...		Antibacterial , Antibiotic
T8298	Vasicine hydrochloride	Peganine hydrochloride	Antibacterial , Antibiotic
	Vasicine hydrochloride (Peganine hydrochloride) (peganine hydrochloride) is an alkaloid isolated from Justicia adhatoda. It possesses an anti-tuberculosis activity.		Antibacterial , Antibiotic
T5997	TBAJ-587		Antibacterial , Antibiotic
	TBAJ-587 is a potent anti-tuberculosis agent. TBAJ-587 inhibits M.tb strain H37Rv growth with MIC90s of 0.006 and <0.02 µg/mL in MABA and LORA assay, respectively. BAJ-587 has more potent activity against M. tuberculosis...		Antibacterial , Antibiotic
T38345	SQ609
	SQ609 is a potential anti-tuberculosis drug selected from a library of dipiperidine derivatives. SQ609 showed significant anti-tuberculous activity in mouse macrophages in vitro[1].
T67136	1-Hydroxy-2-butanone		Endogenous Metabolite , Antibiotic
	1-Hydroxy-2-butanone is a natural product that can be extracted from bamboo juice and tomato leaves and has anti-tuberculosis activity.		Endogenous Metabolite , Antibiotic
T4202	Delamanid	OPC-67683	Anti-infection , Antibacterial , Antibiotic
	Delamanid (OPC-67683) is an anti-tuberculosis agent derived from the nitro-dihydro-imidazooxazole class of compounds that inhibits mycolic acid synthesis of bacterial cell wall.		Anti-infection , Antibacterial , Antibiotic
T12231	NITD-349		Others , Antibacterial
	NITD-349 is an inhibitor of MmpL3. It shows highly potent anti-mycobacterial activity with MIC50 of 23 nM against virulent Mycobacterium tuberculosis H37Rv.		Others , Antibacterial
T9085	JFD01307SC	[(1,1-DIOXIDOTETRAHYDROTHIEN-3-YL)AMINO]	Antibacterial
	JFD01307SC ([(1,1-DIOXIDOTETRAHYDROTHIEN-3-YL)AMINO]) is a glutamine synthetase inhibitor. It is anti-tuberculosis agent and acts as a mimic of L-Glutamate and thus target enzymes involved in glutamine biosynthesis.		Antibacterial
TN1622	Ermanin		NOS , Influenza Virus , COX , HIV Protease , Antibacterial , Antibiotic
	Ermanin is a flavonoid isolated from Tanacetum microphyllum.Ermanin inhibits platelet aggregation and has anti-tuberculosis and anti-viral/bacterial properties.Ermanin has anti-inflammatory activity by inhibiting the exp...
T11449L	Golotimod	Gamma-D-glutamyl-L-tryptophan,SCV 07	Antibiotic
	Golotimod (SCV 07) is an antimicrobial dipeptide with immunomodulatory activity that significantly improves the efficacy of anti-tuberculosis therapy, induces thymic and splenic cell proliferation, modulates macrophage f...		Antibiotic
T3S1612	Kuwanon G	Moracenin B,Kuwanone G	Phosphatase , Antibacterial , Bombesin Receptor , AChR , AChE , Glucosidase
	1. Kuwanon G (Moracenin B) as dual inhibitors of PTP1B and α-glucosidase enzymes, as well as insulin sensitizers, it may potentially be utilized as an effective treatment for Type II diabetes mellitus. 2. Kuwanon G has a...