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TBA-354

Catalog No. T3642 CAS 1257426-19-9

Synonyms: TBA 354

TBA-354 is anti-tuberculous and active against Mycobacterium tuberculosis strain H37Rv.

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TBA-354, CAS 1257426-19-9

Pack Size	Availability	Price/USD
1 mg	In stock	$ 32.00
2 mg	In stock	$ 45.00
5 mg	In stock	$ 72.00
10 mg	In stock	$ 122.00
25 mg	In stock	$ 222.00
50 mg	In stock	$ 369.00
100 mg	In stock	$ 549.00
1 mL * 10 mM (in DMSO)	In stock	$ 79.00

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Purity: 99.35%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	TBA-354 is anti-tuberculous and active against Mycobacterium tuberculosis strain H37Rv.
In vitro	TBA-354 is narrow spectrum and bactericidal in vitro against replicating and nonreplicating Mycobacterium tuberculosis, with potency similar to that of delamanid and greater than that of PA-824. TBA-354 maintains activity against Mycobacterium tuberculosis H37Rv isogenic monoresistant strains and Clinicalal drug-sensitive and drug-resistant isolates [1]. TBA-354 is 5 to 10 times more potent than PA-824, but selected mutants are cross-resistant to PA-824 and delamanid. TBA-354 is 2 to 4 times more potent than PA-824 when combined with bedaquiline, and when administered at a dose equivalent to that of PA-824, TBA-354 demonstrated superior sterilizing efficacy [2].
In vivo	TBA-354 has high bioavailability and a long elimination half-life. In vitro studies suggest a low risk of drug-drug interactions. Low-dose aerosol infection models of acute and chronic murine tuberculosis reveal time- and dose-dependent in vivo bactericidal activity that is at least as potent as that of delamanid and more potent than that of PA-824.

Synonyms	TBA 354
Molecular Weight	436.34
Formula	C19H15F3N4O5
CAS No.	1257426-19-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 55 mg/mL (126.05 mM)

References and Literature

1. Upton AM, et al. Antimicrob Agents Chemother. 2015 Jan;59(1):136-44. 2. Tasneen R, et al. Antimicrob Agents Chemother. 2015 Jan;59(1):129-35.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Anti-Bacterial Compound Library Drug-induced Liver Injury (DILI) Compound Library Anti-Infection Compound Library Clinical Compound Library Bioactive Compounds Library Max Bioactive Compound Library Antibiotics Library ReFRAME Related Library NO PAINS Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

TBA-354 1257426-19-9 Microbiology/Virology Antibiotic Antibacterial inhibit Inhibitor TBA354 Bacterial TBA 354 inhibitor

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