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GSK2200150A

Catalog No. T4531 CAS 1443138-53-1

GSK2200150A is an anti-tuberculosis (TB) agent identified by high-throughput screening (HTS) campaign.

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GSK2200150A, CAS 1443138-53-1

Pack Size	Availability	Price/USD
5 mg	In stock	$ 39.00
10 mg	In stock	$ 64.00
25 mg	In stock	$ 122.00
50 mg	In stock	$ 197.00
100 mg	In stock	$ 293.00
200 mg	In stock	$ 437.00
1 mL * 10 mM (in DMSO)	In stock	$ 43.00

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Purity: 99.24%

Purity: 99.16%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	GSK2200150A is an anti-tuberculosis (TB) agent identified by high-throughput screening (HTS) campaign.
Targets&IC50	M. tuberculosis (strain H37Rv):0.38 μM (MIC)
In vitro	GSK2200150A, a novel agent with a spirocycle core, exhibits strong antimycobacterial properties against the virulent Mycobacterium tuberculosis strain (H37Rv), demonstrating a minimal inhibitory concentration (MIC) of 0.38 μM [1].
Cell Research	GSK2200150A is tested for activity at either single concentration (100 μM) or serially diluted in 10 μL of purified H2O in triplicate in 96 well microtiter plates. M. tuberculosis H37Rv is grown in complete Middlebrook 7H9 media containing albumin, dextrose and catalase (ADC), 20% Tween 80 and 50% glycerol. A bacterial suspension (90 μL) at OD600 nm of 0.001 is added to the wells and incubated for 7 days. Resazurin (10 μL; 0.05%(w/v)) is then added, incubated for 24 h at 37°C, and fluorescence measured at 590 nm using a FLUOstar Omega microplate reader. After subtraction of background fluorescence from all wells, the percentage mycobacterial survival is determined by comparing the fluorescence of wells containing compounds compared to control wells not treated with compound[1].

Molecular Weight	357.47
Formula	C20H23NO3S
CAS No.	1443138-53-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 80 mg/mL

References and Literature

1. Badiola KA, et al. Efficient Synthesis and Anti-Tubercular Activity of a Series of Spirocycles: An Exercise in OpenScience. PLoS One. 2014 Dec 10;9(12):e111782.

Related compound libraries

This product is contained In the following compound libraries：

Antibiotics Library Bioactive Compound Library Anti-Bacterial Compound Library NO PAINS Compound Library Bioactive Compounds Library Max Anti-Infection Compound Library Drug-induced Liver Injury (DILI) Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

GSK2200150A 1443138-53-1 Microbiology/Virology Antibacterial inhibit Inhibitor GSK-2200150A Bacterial inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.