affinity — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T12562	Protein kinase affinity probe 1		Others
	Protein kinase affinity probe 1 is a protein kinase affinity probe for the functional identification of protein kinases (PKs).		Others
T80132	CBP501 Affinity Peptide
	CBP501 Affinity Peptide, a Chk kinase inhibitor, disrupts G2 arrest triggered by DNA-damaging agents and is utilized in cancer research [1].
T8485	THIQ		Melanocortin Receptor
	THIQ is a selective melanocortin-4 receptor (MC4R) agonist (hMC4R and rMC4R with IC50 of 1.2 nM and 0.6 nM , respectively).		Melanocortin Receptor
T13884	Shield-1		Others
	Shield-1 is a specific, high-affinity and cell-permeant ligand of FK506-binding protein-12 (FKBP), and reverses the instability by binding to mutated FKBP (mtFKBP), allowing conditional expression of mtFKBP-fused protein...		Others
T6054	GSK256066		PDE
	GSK256066 is a selective PDE4B(equal affinity to isoforms A-D) inhibitor with IC50 of 3.2 pM, >380, 000-fold selectivity versus PDE1/2/3/5/6 and >2500-fold selectivity against PDE4B versus PDE7.Phase 2.		PDE
T12855	SB 258719		5-HT Receptor
	SB 258719 is a selective antagonist of 5-HT7 receptor(pKi of 7.5).		5-HT Receptor
T23312	SB 204741		5-HT Receptor
	SB 204741 is a 5-HT2B receptor antagonist.		5-HT Receptor
T16421	P-MPPI hydrochloride		5-HT Receptor
	p-MPPI hydrochloride is a selective antagonist of 5-HT1A receptor, and has antidepressant and anxiolytic-like effects.		5-HT Receptor
T11349	GABAA receptor agent 1		GABA Receptor
	GABAA receptor agent 1 has strong anticonvulsant activity and is a high affinity ligand of GABAA receptor.		GABA Receptor
T38862	Nandrolone acetate	19-Nortestosterone 17β-acetate	Others
	Nandrolone acetate (19-Nortestosterone 17β-acetate) is a competitive inhibitor of isomerase with the Ki of 7 μM for Δ5-3-ketosteroid isomerase of Pseudomonas testosreroni.		Others
T12643	(R)-Terazosin		Adrenergic Receptor
	(R)-Terazosin is an active R-enantiomer of Terazosin. (R)-Terazosin is a potent antagonist of α1-adrenoceptor (α1a, α1b and α1d-adrenoceptor with Ki values of 6.51 nM, 1.01 nM and 1.97 nM, respectively).		Adrenergic Receptor
T15418	GS-6201	CVT-6883	Adenosine Receptor
	GS-6201 (CVT-6883) is a selective antagonist of adenosine A2B receptor. GS-6201 shows high affinity and selectivity for the human adenosine A2B receptors with a Ki of 22 nM.		Adenosine Receptor
T4297	Flibanserin	BIMT-17BS,Girosa,BIMT-17	Dopamine Receptor , 5-HT Receptor
	Flibanserin (Girosa) is a serotonergic antidepressant used to treat hypoactive sexual desire disorder. Flibanserin has been associated with a low rate of minor serum aminotransferase elevations during treatment but has n...		Dopamine Receptor , 5-HT Receptor
T26085	Rilapine	Rilapinum
	Rilapine is an atypical antipsychotic with high affinity for the 5-HT6 receptor.
T31362	Deferitazole	SPD602,FBS 0701,SPD-602,FBS0701,FBS-0701,SPD 602	Others
	Deferitazole (FBS 0701) is a novel and orally active, selective and high affinity iron chelator.		Others
T11726	JP1302 dihydrochloride		Adrenergic Receptor
	JP1302 dihydrochloride is a selective, high affinity antagonist of the alpha2C-adrenoceptor (α2C-adrenoceptor), with a Ki (binding affinity) value of 28 nM and a Kb value (antagonist activity) of 16 nM.		Adrenergic Receptor
TN1465	Cannabigerol		NOS , 5-HT Receptor , ROS
	Cannabigerol is a high affinity α±2-adrenergic receptor agonist, moderate affinity 5-HT1A receptor antagonist, and low affinity CB1 receptor antagonist ; also binds to the CB2 receptor; it can relieve interocular pressur...		NOS , 5-HT Receptor , ROS
TP1448L	Astressin acetate	Astressin acetate (170809-51-5 Free base)	CRFR
	Astressin acetate is an antagonist of corticotropin releasing factor (CRF) with low affinity for the CRF binding protein and high affinity for the cloned pituitary receptor(Ki = 2 nM).		CRFR
T4596	4-IBP		Sigma receptor
	4-IBP is a selective σ1 agonist with a high level of affinity for the σ1 receptor (Ki = 1.7 nM) and a moderate affinity for the σ2 receptor (Ki = 25.2 nM) .		Sigma receptor
T2635	Org 27569		Cannabinoid Receptor
	Org 27569, an allosteric modulator of cannabinoid CB1 receptor, can induce a CB1 receptor state that is characterized by decreased inverse agonist affinity and enhanced agonist affinity.		Cannabinoid Receptor