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Deferitazole

Catalog No. T31362 CAS 945635-15-4

Synonyms: SPD602, FBS 0701, SPD-602, FBS0701, FBS-0701, SPD 602

Deferitazole (FBS 0701) is a novel and orally active, selective and high affinity iron chelator.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Deferitazole, CAS 945635-15-4

Pack Size	Availability	Price/USD
1 mg	In stock	$ 130.00
5 mg	In stock	$ 320.00
10 mg	In stock	$ 480.00
25 mg	In stock	$ 786.00
50 mg	In stock	$ 1,080.00

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Purity: 98.26%

Biological Description

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Description

Deferitazole (FBS 0701) is a novel and orally active, selective and high affinity iron chelator.

In vitro

Deferitazole (FBS0701) displays a high affinity and selectivity for iron(III) as demonstrated by the log β2 = 33.39 ± 0.03 and the pFe(3+) value of 22.3. Two equilibrating isomeric forms of the iron(III) complex exist under biological conditions. Deferitazole also binds the trivalent metals Al(III) and La(III) with high affinity; log β2 values, 26.68 and 21.55 respectively. The affinity of Deferitazole for divalent cations is somewhat lower, with the exception of Cu(II) which possesses a log β2 value of 25.5; Deferitazole scavenges iron from labile sources such as citrate and albumin with efficiencies comparable with those of other therapeutic iron chelators, including deferasirox, deferiprone and desferrioxamine. The Fe(III)(Deferitazole)2 is stable under physiological conditions and does not redox cycle. The high affinity of Deferitazole for iron(III) renders it unlikely that this chelator will lead to the redistribution of iron and consequently Deferitazole shows considerable promise as a therapeutic iron(III) chelator.[1]

Synonyms	SPD602, FBS 0701, SPD-602, FBS0701, FBS-0701, SPD 602
Molecular Weight	399.46
Formula	C18H25NO7S
CAS No.	945635-15-4

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Hider RC, et al. Deferitazole, a new orally active iron chelator. Dalton Trans. 2015 Mar 21;44(11):5197-204. 2. Ferrer P, et al. Antimalarial iron chelator FBS0701 blocks transmission by Plasmodium falciparum gametocyte activation inhibition. Antimicrob Agents Chemother. 2015 Mar;59(3):1418-26. 3. Gumienna-Kontecka E, et al. Iron chelating strategies in systemic metal overload, neurodegeneration and cancer. Curr Med Chem. 2014;21(33):3741-67. 4. Ferrer P, et al. Antimalarial iron chelator, FBS0701, shows asexual and gametocyte Plasmodium falciparum activity and single oral dose cure in a murine malaria model. PLoS One. 2012;7(5):e37171.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Deferitazole 945635-15-4 Others SPD602 FBS 0701 SPD-602 FBS0701 FBS-0701 SPD 602 inhibitor inhibit

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