Shopping Cart

Remove All
Your shopping cart is currently empty

Shield-1

Name: Shield-1
Brand: TargetMol
SKU: T13884
Price: 163 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T13884Cas No. 914805-33-7

Shield-1 is a specific, high-affinity, and cell-permeable ligand for FK506-binding protein 12 (FKBP) and reverses instability by binding to mutant FKBP (mtFKBP), allowing conditional expression of mtFKBP fusion proteins.

Shield-1

🥰Excellent

Purity: 99.08%

Catalog No. T13884Cas No. 914805-33-7

Pack Size	Price	Availability
1 mg	$163	In Stock
5 mg	$372	In Stock
10 mg	$592	In Stock
25 mg	$941	In Stock
50 mg	$1,280	In Stock
100 mg	$1,720	In Stock
500 mg	$3,430	In Stock
1 mL x 10 mM (in DMSO)	$555	In Stock

Add to Cart

Add to Quotation

Bulk & Custom

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.08%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	Shield-1 is a specific, high-affinity, and cell-permeable ligand for FK506-binding protein 12 (FKBP) and reverses instability by binding to mutant FKBP (mtFKBP), allowing conditional expression of mtFKBP fusion proteins.
Targets&IC50	FKBP12 V2A mutant-YFP fusion protein (NIH3T3 cells):60 nM, FKBP12 V2A mutant-YFP fusion protein (NIH3T3 cells):100 nM (EC50)
In vitro	METHODS: Transfected cells with mtFKBP-TRPV5 were treated with Shield-1 (1 μM, 24 hours), the ligand was washed out, and the mtFKBP-TRPV5 signal was subsequently measured at different time points. RESULTS mtFKBP-TRPV5 protein levels decreased rapidly with a half-life (t) of 2.53 ± 0.59 hours. [1]

Chemical Properties

Molecular Weight	748.9
Formula	C₄₂H₅₆N₂O₁₀
Cas No.	914805-33-7
Smiles	CC[C@H](C(=O)N1CCCC[C@H]1C(=O)O[C@H](CCc1ccc(OC)c(OC)c1)c1cccc(OCCN2CCOCC2)c1)c1cc(OC)c(OC)c(OC)c1
Relative Density.	1.168 g/cm3 (Predicted)
Color	White
Appearance	Viscous

Storage & Solubility Information

Storage

Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (333.82 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (6.68 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.3353 mL	6.6765 mL	13.3529 mL	66.7646 mL
5 mM	0.2671 mL	1.3353 mL	2.6706 mL	13.3529 mL
10 mM	0.1335 mL	0.6676 mL	1.3353 mL	6.6765 mL
20 mM	0.0668 mL	0.3338 mL	0.6676 mL	3.3382 mL
50 mM	0.0267 mL	0.1335 mL	0.2671 mL	1.3353 mL
100 mM	0.0134 mL	0.0668 mL	0.1335 mL	0.6676 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc