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Astressin acetate

Catalog No. TP1448L

Synonyms: Astressin acetate (170809-51-5 Free base)

Astressin acetate is an antagonist of corticotropin releasing factor (CRF) with low affinity for the CRF binding protein and high affinity for the cloned pituitary receptor(Ki = 2 nM).

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Astressin acetate, CAS N/A

Pack Size	Availability	Price/USD
1 mg	In stock	$ 394.00
5 mg	In stock	$ 1,571.00
10 mg	In stock	$ 2,357.00
25 mg	In stock	$ 4,242.00

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Purity: 96.87%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Astressin acetate is an antagonist of corticotropin releasing factor (CRF) with low affinity for the CRF binding protein and high affinity for the cloned pituitary receptor(Ki = 2 nM).
In vitro	Astressin acetate exhibits high affinity for cloned human CRF-RA1 stably expressed in CHO cells and high potency to inhibit ACTH secretion[2].
In vivo	Astressin acetate (i.c.v. 30 min before and 10 min after seizures) decreases damage in some hippocampal cell fields by as much as 84%. Astressin acetate protects even if administered only 10 min following excitotoxin exposure[1]. Astressin acetate is significantly more potent than any previously tested antagonist in reducing hypophyseal corticotropin secretion in stressed or adrenalectomized rats. Astressin acetate (30 and 100 μg/kg; i.v.) produces a significant decrease in ACTH levels at 45 and 90 min, respectively[2]. Astressin acetate significantly reverses the anxiogenic-like response induced by both social stress and i.c.v. rat/humanCRF (r/hCRF) on the elevated plus-maze, but fails to block the effects of r/hCRF-induced locomotor activity in a familiar environment[3].

Synonyms	Astressin acetate (170809-51-5 Free base)
Molecular Weight	3623.21
Formula	C163H273N49O44

Storage

store at low temperature,keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Maecker H, et al. Astressin, a novel and potent CRF antagonist, is neuroprotective in the hippocampus when administered after a seizure. Brain Res. 1997 Jan 2;744(1):166-70. 2. Gulyas J, et al. Potent, structurally constrained agonists and competitive antagonists of corticotropin-releasing factor. Proc Natl Acad Sci U S A. 1995 Nov 7;92(23):10575-9. 3. Spina MG, et al. Behavioral effects of central administration of the novel CRF antagonist astressin in rats. Neuropsychopharmacology. 2000 Mar;22(3):230-9.

Related compound libraries

This product is contained In the following compound libraries：

Peptide Compound Library

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Keywords

Astressin acetate GPCR/G Protein CRFR Astressin acetate (170809-51-5 Free base) 170809-51-5 Free base Astressin Acetate 170809-51-5 inhibitor inhibit

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