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Search Results for " th2 "

20

Compounds

Cat No. Product Name Synonyms Targets
TQ0265 Indolelactic acid Endogenous Metabolite
Indolelactic acid is a metabolite of tryptophan in Azotobacter vinelandii cultures.
T3965 Fevipiprant QAW039,NVP-QAW039 GPR , Prostaglandin Receptor
Fevipiprant (NVP-QAW039) is a selective, potent, reversible competitive CRTh2 antagonist.
T25465 GS143 GS-143,GS 143 IκB/IKK , E1/E2/E3 Enzyme , NF-κB
GS143 is a selec­tive IκBα ubiquitination inhibitor with an IC50 of 5.2 μM for SCFβTrCP1-mediated IκBα ubiquitylation. GS143 sup­presses NF-κB acti­va­tion and tran­scrip­tion of tar­get genes and does not inhibit protea...
T10084 CRTh2 antagonist 1 GPR
CRTh2 antagonist 1 is a CRTh2 antagonist (IC50: 89 nM).
T2069L TH287 hydrochloride DNA/RNA Synthesis , MTH1
TH287 is a selective MTH1 inhibitor(IC50 : 0.8 nM). It causees incorporation of oxidized dNTPs in cancer cells, leading to DNA damage, cytotoxicity and therapeutic responses in patient-derived mouse xenografts.
T8344 CPTH2 Apoptosis , Histone Acetyltransferase
CPTH2 is a histone acetyltransferase inhibitor modulating Gcn5 network.
T2069 TH287 TH287 hydrochloride DNA/RNA Synthesis , MTH1
TH287 is a potent inhibitor of MTH1 (NUDT1), less potent for MTH2, NUDT5, NUDT12, NUDT14, and NUDT16.
T10889 CRTh2 antagonist 2 GPR
CRTh2 antagonist 2 is a selective and potent CRTH2 antagonist, IC50≤10 nM. CRTh2 antagonist 2 can be used to study the direction of androgenic alopecia.
T10890 CRTh2 antagonist 3 Others
CRTh2 antagonist 3 is a powerful chemokine receptor homologous molecule expressed on Th2 cell (CRTh2) antagonists. CRTh2 antagonist 3 enhanced the activity of PDK1 on short peptide substrates with EC50 of 2 μM and Kd of ...
T70364 TH251
TH251 is a highly selective antagonist of LIMK1 and LIMK2 (LIMK1/2).
T10891 CRTH2-IN-1 Ramatroban analog P450
CRTH2-IN-1 is a selective prostaglandin D2 receptor DP2 (CRTH2) antagonist, a Ramatroban analog, with an IC50 of 6 nM in the human DP2 binding assay.
T22693 CPTH2 (hydrochloride) (357649-93-5 free base) CPTH2 (hydrochloride) Others
CPTH2 is an inhibitor of the HAT activity of Gcn5.
T16425 PA452 Retinoid Receptor , RAR/RXR 
PA452 is a selective antagonist of retinoic X receptor (RXR) and suppresses the effect of Retinoic acid on Th1/Th2 development.
TN2088 Platycodin D2 IL Receptor , HBV
Platycodin D2 , a less hemolytic saponin, can improve specific cellular and humoral responses to hepatitis B surface antigen in mice, it could be safely used as adjuvant eliciting Th1 and Th2 immune responses. Polygalaci...
T17214 Valencene NSC 148969,NSC-148969,NSC148969 Others , Antioxidant , NF-κB
Valencene (NSC-148969) is a sesquiterpenoid isolated from Cyperus rotundus and is an aroma component of citrus fruits and citrus-derived odors.ValenceneValencene has anti-allergic, anti-inflammatory, anti-melanogenic, an...
T0117 Suplatast (Tosilate) IPD 1151T,Suplatast tosilate,Suplatast Tosylate IL Receptor , Interleukin
Suplatast Tosilate (IPD 1151T) is a novel capsular anti-asthmatic drug. It ( IC50 above 100 μM) inhibits both IgE production, IL-4 and IL-5 synthesis.
T14565 BI-671800 AP-761,Cmpd A GPR , Prostaglandin Receptor
BI-671800 (AP-761) is a highly specific and potent antagonist of chemoattractant receptor-homologous molecule on Th2 cells (DP2/CRTH2). With IC50 values of 4.5 nM and 3.7 nM for PGD2 binding to CRTH2 in hCRTH2 and mCRTH2...
T3520 Setipiprant KYTH-105,ACT-129968 GPR , Prostaglandin Receptor
Setipiprant (ACT-129968) is an orally available, selective CRTH2 antagonist (IC50: 6.0 nM). CRTH2 is a G protein-coupled receptor for prostaglandin (PGD2). PGD2 is produced by the mast cells and is a key mediator in vari...
T4674 SB297006 SB 297006 CCR
SB297006 is an antagonist of C-C chemokine receptor 3 (CCR3; IC50 = 39 nM), which normally is activated by eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES, and MIP-1δ. It is at least 250-fold selective for CCR3 over a panel of ...
T2S2173 (E)-Naringenin chalcone Isosalipurpol,Chalconaringenin,trans-2'4'6'4-tetrahydroxychalcone Others
Naringenin chalcone (Isosalipurpol) has antiallergic activity Naringenin chalcone suppresses asthmatic symptoms by inhibiting Th2 cytokine production from CD4 T cells. Naringenin chalcone is a potent tomato flavonoid tha...
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