Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Setipiprant (ACT-129968) is an orally available, selective CRTH2 antagonist (IC50: 6.0 nM). CRTH2 is a G protein-coupled receptor for prostaglandin (PGD2). PGD2 is produced by the mast cells and is a key mediator in various inflammatory diseases, including allergy and asthma. Binding of PGD2 to CRTH2, which are expressed on the surface of blood-borne cells, induces chemotaxis of Th2 cells, basophils, and eosinophils, and stimulates cytokine release from these cells.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
10 mg | In stock | $ 39.00 | |
25 mg | In stock | $ 72.00 | |
50 mg | In stock | $ 118.00 | |
100 mg | In stock | $ 189.00 | |
200 mg | In stock | $ 278.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 30.00 |
Description | Setipiprant (ACT-129968) is an orally available, selective CRTH2 antagonist (IC50: 6.0 nM). CRTH2 is a G protein-coupled receptor for prostaglandin (PGD2). PGD2 is produced by the mast cells and is a key mediator in various inflammatory diseases, including allergy and asthma. Binding of PGD2 to CRTH2, which are expressed on the surface of blood-borne cells, induces chemotaxis of Th2 cells, basophils, and eosinophils, and stimulates cytokine release from these cells. |
Targets&IC50 | CRTH2:6.0 nM |
Synonyms | KYTH-105, ACT-129968 |
Molecular Weight | 402.42 |
Formula | C24H19FN2O3 |
CAS No. | 866460-33-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 36 mg/mL
You can also refer to dose conversion for different animals. More
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Setipiprant 866460-33-5 Endocrinology/Hormones GPCR/G Protein Immunology/Inflammation Prostaglandin Receptor GPR rhinitis KYTH 105 selective KYTH-105 calcium liberation Inhibitor ACT-129968 dog HEK-293 cAMP asthma KYTH105 oral ACT 129968 ACT129968 inhibit rat inhibitor