Powder: -20°C for 3 years
In solvent: -80°C for 2 years
TH287 is a potent inhibitor of MTH1 (NUDT1), less potent for MTH2, NUDT5, NUDT12, NUDT14, and NUDT16.
Description | TH287 is a potent inhibitor of MTH1 (NUDT1), less potent for MTH2, NUDT5, NUDT12, NUDT14, and NUDT16. |
Targets&IC50 | MTH1:0.8 nM |
In vitro | TH287 selectively and effectively kill U2OS and other cancer cell lines with less toxic to several primary or immortalized cells, and induces oxidative DNA damage. [1] |
In vivo | In C57Bl/6 mice, TH287 (5 mk/kg, i.p.) causes a peak time and maximum concentration of 0.5 h and 0.82 μM. [2] |
Synonyms | TH287 hydrochloride |
Molecular Weight | 269.13 |
Formula | C11H10Cl2N4 |
CAS No. | 1609960-30-6 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
Ethanol: 10 mg/mL (37.15 mM), warmed
DMSO: 49 mg/mL (160.3 mM)
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
TH287 1609960-30-6 Cell Cycle/Checkpoint DNA Damage/DNA Repair MTH1 DNA/RNA Synthesis inhibit TH 287 TH-287 TH287 hydrochloride Inhibitor inhibitor