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TH287

TH287
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Purity:99%
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TH287

Catalog No. T2069Cas No. 1609960-30-6
TH287 is a potent inhibitor of MTH1 (NUDT1), less potent for MTH2, NUDT5, NUDT12, NUDT14, and NUDT16.
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Pack SizePrice/USDAvailabilityQuantity
1 mg$31In Stock
2 mg$41In Stock
5 mg$66In Stock
10 mg$97In Stock
25 mg$198In Stock
50 mg$386In Stock
100 mg$573In Stock
1 mL x 10 mM (in DMSO)$72In Stock
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Product Introduction

Bioactivity
Description
TH287 is a potent inhibitor of MTH1 (NUDT1), less potent for MTH2, NUDT5, NUDT12, NUDT14, and NUDT16.
In vitro
TH287 selectively and effectively kill U2OS and other cancer cell lines with less toxic to several primary or immortalized cells, and induces oxidative DNA damage. [1]
In vivo
In C57Bl/6 mice, TH287 (5 mk/kg, i.p.) causes a peak time and maximum concentration of 0.5 h and 0.82 μM. [2]
AliasTH287 hydrochloride
Chemical Properties
Molecular Weight269.13
FormulaC11H10Cl2N4
Cas No.1609960-30-6
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
Ethanol: 10 mg/mL (37.15 mM)
DMSO: 49 mg/mL (160.3 mM)
Solution Preparation Table
DMSO/Ethanol
1mg5mg10mg50mg
1 mM3.7157 mL18.5784 mL37.1568 mL185.7838 mL
5 mM0.7431 mL3.7157 mL7.4314 mL37.1568 mL
10 mM0.3716 mL1.8578 mL3.7157 mL18.5784 mL
20 mM0.1858 mL0.9289 mL1.8578 mL9.2892 mL
DMSO
1mg5mg10mg50mg
50 mM0.0743 mL0.3716 mL0.7431 mL3.7157 mL
100 mM0.0372 mL0.1858 mL0.3716 mL1.8578 mL

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