tbk1 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T7951	TBK1/IKKε-IN-5		IκB/IKK
	TBK1/IKKε-IN-5 is a dual TBK1 and IKKε inhibitor(IC50 of 1 nM and 5.6 nM, respectively).		IκB/IKK
T15559	TBK1/IKKε-IN-2		IκB/IKK
	TBK1/IKKε-IN-2 is a dual inhibitor of TBK1 and IKKε.		IκB/IKK
T73322	TBK1-IN-1		IκB/IKK
	TBK1-IN-1 is a specific and potent TANK-binding kinase 1 (TBK1) inhibitor (IC50: 22.4 nM) with anticancer activity.TBK1-IN-1 inhibits the expression of TBK1 downstream target genes, cxcl10 and ifnβ.		IκB/IKK
T39841	TBK1/IKKε-IN-6	TBK1/IKKε-IN-6
	TBK1/IKKε-IN-6 (example 110) is a potent inhibitor of TBK1 and IKKε, with IC50 values of less than 100 nM for both enzymes.
T38263	TBK1/IKKε-IN-4	TBK1/IKKε-IN-4
	TBK1/IKKε-IN-4, a 6-aminopyrazolopyrimidine derivative, serves as a potent, selective inhibitor for TBK1 and IKKε, demonstrating IC50 values of 13 nM and 59 nM, respectively. This compound exhibits significantly reduced ...
T36247	TBK1 control PROTAC® 4
	Negative control for TBK1 PROTAC 3i. Binds TBK1 with high affinity, but exhibits no significant degradation of TBK1. PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.
T13097	TBK1/IKKε-IN-1		IκB/IKK
	TBK1/IKKε-IN-1 is a dual inhibitor of TBK1 and IKKε (IC50s of <100 nM).		IκB/IKK
T10477	BAY-985		IκB/IKK
	BAY-985 is a potent, selective, and orally active ATP-competitive dual inhibitor of TBK1 and IKKε (IC50s: 2/30 and 2 nM for TBK1 (low/high ATP) and IKKε) with antitumor efficacy.		IκB/IKK
T5674	H-151		STING
	H-151 is a highly potent and selective STING antagonist. H-151 covalently binds to Cys91 of STING and inhibits palmitoylation of Cys91, thereby inhibiting STING activity. H-151 can be used in the study of autoinflammator...		STING
T9028	STING-IN-2	C-170	STING
	STING-IN-2 (C-170) is a potent and covalent inhibitor of STING. C-170 efficiently inhibits both mouse STING (mmSTING) and human STING (hsSTING). It can be used for autoinflammatory disease research.		STING
T60086	TTBK1-IN-2	N-[4-(4-chlorophenoxy)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine	Microtubule Associated
	TTBK1-IN-2 (N-[4-(4-chlorophenoxy)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine) is an inhibitor of Tau-Tubulin kinase (TTBK1) with IC50s of 0.24 and 4.22 µM. TTBK1-IN-2 reduces TDP-43 phosphorylation both in cell cultures ...		Microtubule Associated
T40348	TTBK1-IN-1	TTBK1-IN-1
	TTBK1-IN-1 is a highly potent and selective inhibitor of tau tubulin kinase 1 (TTBK1), capable of penetrating the blood-brain barrier with ease. With an IC 50 value of 2.7 nM, TTBK1-IN-1 exhibits strong inhibitory activi...
T72808	(R)-TTBK1-IN-1
	(R)-TTBK1-IN-1 is a potent, selective, and brain-penetrant inhibitor of tau tubulin kinase 1 (TTBK1), serving as an enantiomer of TTBK1-IN-1. It finds application in the research of Alzheimer’s disease and related tauopa...
T5540	GSK8612		IκB/IKK
	GSK8612 is a highly selective and potent inhibitor of Tank-binding Kinase-1 (TBK1, pIC50: 6.8) .		IκB/IKK
T5162	MRT67307 HCl (1190378-57-4(free base))		IκB/IKK , AMPK , Autophagy
	MRT67307 is a kinase inhibitor of TBK1, MARK1-4, IKKε, and NUAK1 (IC50: 19, 27-52, 160, and 230 nM, respectively).		IκB/IKK , AMPK , Autophagy
T15558	GSK319347A		IκB/IKK
	GSK319347A is a selective and potent dual inhibitor of TBK1 and IKKε with potential anti-tumor activity and inhibition of IKK2 activity, which can be used in the study of bladder cancer and lung adenocarcinoma.		IκB/IKK
T7329	C-178		STING
	C-178 is a covalent inhibitor of STING, binds to Cys91 on STING to block its palmitoylation and prevents recruitment and phosphorylation of TBK1 in HEK293T cells.		STING
T9029	STING-IN-3	C-171	STING
	STING-IN-3 (C-171) is an inhibitor of stimulator of interferon genes (STING). It binds to STING, inhibits its palmitoylation, and prevents the recruitment and phosphorylation of TBK1.		STING
T7081	CCCP	Carbonyl Cyanide m-Chlorophenylhydrazone,Carbonyl cyanide 3-chlorophenylhydrazone	Apoptosis , IκB/IKK , COX , Mitochondrial Metabolism , STING , IFNAR , Antibacterial
	CCCP (Carbonyl Cyanide m-Chlorophenylhydrazone) is an oxidative phosphorylation (OXPHOS) inhibitor and mitochondrial proton carrier uncoupler. CCCP inhibits the activation of STING and its downstream signaling molecules ...
T5317	Cridanimod	CMA,XBIO-101,10-carboxymethyl-9-acridanone	Progesterone Receptor , STING , IFNAR
	Cridanimod (10-carboxymethyl-9-acridanone, CMA) is a potent STING agonist that directly binds to STING and triggers a strong antiviral response through the TBK1/IRF3 route.		Progesterone Receptor , STING , IFNAR