Powder: -20°C for 3 years | In solvent: -80°C for 1 year
GSK319347A is a selective and potent dual inhibitor of TBK1 and IKKε with potential anti-tumor activity and inhibition of IKK2 activity, which can be used in the study of bladder cancer and lung adenocarcinoma.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 67.00 | |
5 mg | In stock | $ 155.00 | |
10 mg | In stock | $ 268.00 | |
25 mg | In stock | $ 563.00 | |
50 mg | In stock | $ 958.00 | |
100 mg | In stock | $ 1,280.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 358.00 |
Description | GSK319347A is a selective and potent dual inhibitor of TBK1 and IKKε with potential anti-tumor activity and inhibition of IKK2 activity, which can be used in the study of bladder cancer and lung adenocarcinoma. |
Targets&IC50 | TBK1:93 nM, IKK2:790 nM, IKKε:469 nM |
In vitro | GSK319347A (Compound 1) inhibits the TBK1 enzyme with an IC50 of 93 nM, demonstrating good cell potency at 72 nM. Additionally, IKK-3 Inhibitor shows excellent selectivity against cell-cycle kinases CDK2 and AurB[1]. IKK-3 Inhibitor (Compound 13) is a novel IκB kinase 2 (IKK2) inhibitor with an IC50 of 790 nM[1]. |
Molecular Weight | 469.53 |
Formula | C22H19N3O5S2 |
CAS No. | 862812-98-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 40 mg/mL (85.19 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
GSK319347A 862812-98-4 NF-Κb IκB/IKK GSK-319347A inhibitor inhibit