Powder: -20°C for 3 years | In solvent: -80°C for 1 year
C-178 is a covalent inhibitor of STING, binds to Cys91 on STING to block its palmitoylation and prevents recruitment and phosphorylation of TBK1 in HEK293T cells.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
2 mg | In stock | $ 37.00 | |
5 mg | In stock | $ 59.00 | |
10 mg | In stock | $ 97.00 | |
25 mg | In stock | $ 197.00 | |
50 mg | In stock | $ 313.00 | |
100 mg | In stock | $ 493.00 | |
500 mg | In stock | $ 1,090.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 61.00 |
Description | C-178 is a covalent inhibitor of STING, binds to Cys91 on STING to block its palmitoylation and prevents recruitment and phosphorylation of TBK1 in HEK293T cells. |
In vitro | C-178 (0.01-1.25 μM) selectively reduces STING-, but not RIG-I- or TBK1-, mediated IFN-β reporter activity in HEK293 cells. It also prevents increases in Ifnb1 expression in bone marrow-derived macrophages (BMDMs) induced by cyclic di-GMP , double-stranded DNA, and LPS when used at a concentration of 0.5 μM. |
Molecular Weight | 322.27 |
Formula | C17H10N2O5 |
CAS No. | 329198-87-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 3.22 mg/mL (10 mM)
You can also refer to dose conversion for different animals. More
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C-178 329198-87-0 Immunology/Inflammation STING C178 MITA inhibit Inhibitor MPYS C 178 ERIS Stimulator of Interferon Genes TMEM173 inhibitor