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STING-IN-2

Catalog No. T9028 CAS 346691-38-1

Synonyms: C-170

C-170 is a potent and covalent inhibitor of STING. C-170 efficiently inhibits both mouse STING (mmSTING) and human STING (hsSTING). It can be used for autoinflammatory disease research.

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STING-IN-2, CAS 346691-38-1

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	C-170 is a potent and covalent inhibitor of STING. C-170 efficiently inhibits both mouse STING (mmSTING) and human STING (hsSTING). It can be used for autoinflammatory disease research.
In vitro	In THP-1 cells, pretreated with STING-IN-2 (C-170;?0.5 μM) and stimulated with cGAMP.?STING-IN-2 (C-170) treatment decreases the IFNB1 and TNF mRNA levels, and also reduces the p-TBK1 levels

Synonyms	C-170
Molecular Weight	288.3
Formula	C15H16N2O4
CAS No.	346691-38-1

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 22.5 mg/mL (78.04 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Simone M Haag, et al. Targeting STING with covalent small-molecule inhibitors. Nature. 2018 Jul;559(7713):269-273.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

STING-IN-2 346691-38-1 Immunology/Inflammation STING Inhibitor autoinflammatory ERIS MPYS cGAMP MITA IFNB1 STING IN 2 Stimulator of Interferon Genes TMEM173 inhibit palmitoylation STINGIN2 C-170 p-TBK1 TNF inhibitor

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