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STING-IN-2

Name: STING-IN-2
Brand: TargetMol
SKU: T9028
Price: 45 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T9028Cas No. 346691-38-1

Alias C-170

STING-IN-2 (C-170) is a potent, covalent inhibitor of STING, effectively targeting both mouse (mmSTING) and human STING (hsSTING), and is applicable for autoinflammatory disease research.

STING-IN-2

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Purity: 98.61%

Catalog No. T9028Alias C-170Cas No. 346691-38-1

STING-IN-2 (C-170) is a potent, covalent inhibitor of STING, effectively targeting both mouse (mmSTING) and human STING (hsSTING), and is applicable for autoinflammatory disease research.

Pack Size	Price	Availability
10 mg	$45	In Stock
25 mg	$90	In Stock
50 mg	$144	In Stock
100 mg	$225	In Stock
1 mL x 10 mM (in DMSO)	$51	In Stock

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Purity:98.61%

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COA HPLC HNMR LCMS

Product Introduction

Bioactivity

Description	STING-IN-2 (C-170) is a potent, covalent inhibitor of STING, effectively targeting both mouse (mmSTING) and human STING (hsSTING), and is applicable for autoinflammatory disease research.
In vitro	In THP-1 cells, pretreated with STING-IN-2 (C-170;?0.5 μM) and stimulated with cGAMP.?STING-IN-2 (C-170) treatment decreases the IFNB1 and TNF mRNA levels, and also reduces the p-TBK1 levels
Synonyms	C-170

Chemical Properties

Molecular Weight	288.3
Formula	C₁₅H₁₆N₂O₄
Cas No.	346691-38-1
Smiles	CCCCc1ccc(NC(=O)c2ccc(o2)[N+]([O-])=O)cc1
Relative Density.	1.260 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 22.5 mg/mL (78.04 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.4686 mL	17.3430 mL	34.6861 mL	173.4305 mL
5 mM	0.6937 mL	3.4686 mL	6.9372 mL	34.6861 mL
10 mM	0.3469 mL	1.7343 mL	3.4686 mL	17.3430 mL
20 mM	0.1734 mL	0.8672 mL	1.7343 mL	8.6715 mL
50 mM	0.0694 mL	0.3469 mL	0.6937 mL	3.4686 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc