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CCCP

Catalog No. T7081   CAS 555-60-2
Synonyms: Carbonyl Cyanide m-Chlorophenylhydrazone, Carbonyl cyanide 3-chlorophenylhydrazone

CCCP (Carbonyl Cyanide m-Chlorophenylhydrazone) inhibits activation of STING and its downstream signalling molecules, TBK1 and IRF3. CCCP inhibits STING-mediated IFN-β production via disrupting mitochondrial membrane potential (MMP).

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CCCP Chemical Structure
CCCP, CAS 555-60-2
Pack Size Availability Price/USD Quantity
100 mg In stock $ 41.00
200 mg In stock $ 58.00
500 mg In stock $ 97.00
1 mL * 10 mM (in DMSO) In stock $ 45.00
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Purity: 99.64%
Purity: 98.55%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description CCCP (Carbonyl Cyanide m-Chlorophenylhydrazone) inhibits activation of STING and its downstream signalling molecules, TBK1 and IRF3. CCCP inhibits STING-mediated IFN-β production via disrupting mitochondrial membrane potential (MMP).
Synonyms Carbonyl Cyanide m-Chlorophenylhydrazone, Carbonyl cyanide 3-chlorophenylhydrazone
Molecular Weight 204.62
Formula C9H5ClN4
CAS No. 555-60-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 20 mg/mL

Ethanol: 5 mg/mL

TargetMolReferences and Literature

1. Kwon D, et al. Carbonyl cyanide 3-chlorophenylhydrazone (CCCP) suppresses STING-mediated DNA sensing pathway through inducing mitochondrial fission. Biochem Biophys Res Commun. 2017 Aug 30. pii: S202006-291X(17)31704-7. 2. Sinha D, et al. Synergistic efficacy of Bisbenzimidazole and Carbonyl Cyanide 3-Chlorophenylhydrazonecombination against MDR bacterial strains. Sci Rep. 2017 Mar 17;7:44419. 3. Kawamoto A, et al. Measurement of technetium-99m sestamibi signals in rats administered a mitochondrial uncoupler and in a rat model of heart failure. PLoS One. 2015 Jan 16;10(1):e0117091. 4. Luo P, Yan H, Du J, et al. PLK1 (polo like kinase 1)-dependent autophagy facilitates gefitinib-induced hepatotoxicity by degrading COX6A1 (cytochrome c oxidase subunit 6A1)[J]. Autophagy. 2020: 1-17. 5. Zhang Y, Xu X, Hu M, et al. SPATA33 is an autophagy mediator for cargo selectivity in germline mitophagy[J]. Cell Death & Differentiation. 2020: 1-15.

TargetMolCitations

1. Xu Q, Fu Q, Li Z, et al. The flavonoid procyanidin C1 has senotherapeutic activity and increases lifespan in mice. Nature Metabolism. 2021: 1-21. 2. Fan Y, Li C, Bai S, et al. NIR‐II Emissive Ru (II) Metallacycle Assisting Fluorescence Imaging and Cancer Therapy. Small. 2022: 2201625 3. Zhang Y, Xu X, Hu M, et al. SPATA33 is an autophagy mediator for cargo selectivity in germline mitophagy. Cell Death & Differentiation. 2020: 1-15. 4. Luo P, Yan H, Du J, et al. PLK1 (polo like kinase 1)-dependent autophagy facilitates gefitinib-induced hepatotoxicity by degrading COX6A1 (cytochrome c oxidase subunit 6A1). Autophagy. 2021 Oct;17(10):3221-3237. 5. Liu C, Wang L, Wang P, et al.The Mechanism of Tigecycline Resistance in Acinetobacter baumannii Revealed by Proteomic and Genomic Analysis.International Journal of Molecular Sciences.2023, 24(10): 8652. 6. Wang K, Zhou Z, Huang L, et al.PINK1 dominated mitochondria associated genes signature predicts abdominal aortic aneurysm with metabolic syndrome.Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease.2024, 1870(2): 166919. 7. Liu C, Liu J, Lu Q, et al.The Mechanism of Tigecycline Resistance in Acinetobacter baumannii under Sub-Minimal Inhibitory Concentrations of Tigecycline.International Journal of Molecular Sciences.2024, 25(3): 1819.

Related compound libraries

This product is contained In the following compound libraries:
Pyroptosis Compound Library Cuproptosis Compound Library Metabolism Compound Library Apoptosis Compound Library Anti-Prostate Cancer Compound Library Inhibitor Library Anti-Infection Compound Library Cytokine Inhibitor Library Mitochondria-Targeted Compound Library Nonsteroidal Anti-Inflammatory Compound Library

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Keywords

CCCP 555-60-2 Apoptosis Immunology/Inflammation Metabolism Microbiology/Virology Neuroscience NF-Κb IκB/IKK IFNAR Antibacterial STING COX Mitochondrial Metabolism MPYS Carbonyl Cyanide m-Chlorophenylhydrazone Carbonyl cyanide 3-chlorophenylhydrazone TMEM173 Interferon-alpha/beta receptor Stimulator of Interferon Genes Bacterial ERIS MITA inhibit Inhibitor Interferon-α/β receptor inhibitor

 

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