set — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T37097	SET 2		TRP/TRPV Channel
	SET 2 is an antagonist of transient receptor potential vanilloid type 2(TRPV2) with an IC50 of 0.46 μM. SET 2 shows selectivity over TRPV1, TRPV3 and TRPV4.		TRP/TRPV Channel
T8838	CCI-007		Apoptosis , Histone Methyltransferase
	CCI 007 is a selective inhibitor of MLL-r, CALM-AF10 and SET-NUP214 leukemia with IC50 of 3.5 uM against MLL-r leukemia cell line PER-485		Apoptosis , Histone Methyltransferase
T9744	MP07-66		Phosphatase
	MP07-66 is a novel FTY720-analog devoid of immunosuppressive effects leads to the reactivation of PP2A, which in turn triggers apoptosis of CLL cells.		Phosphatase
T8879	MR837	ZINC30303842,NSD2-PWWP1 antagonist 3f	Others , Histone Methyltransferase
	MR837 (NSD2-PWWP1 antagonist 3f) is a NSD2-PWWP1 antagonist.		Others , Histone Methyltransferase
T4583	PFI-2 hydrochloride	(R)-PFI-2 hydrochloride,PFI-2 HCl	Histone Methyltransferase
	PFI-2 hydrochloride ((R)-PFI-2 hydrochloride) is a potent, highly selective, and cell-active inhibitor of the methyltransferase activity of SETD7 (IC50: 2 nM), 500 fold active than (S)-PFI-2.		Histone Methyltransferase
T1987	PFI-2	PFI2,PFI 2,(R)-PFI-2	Histone Methyltransferase
	PFI-2 is an effective, specific and cell-active lysine methyltransferase SETD7 inhibitor (Ki/IC50: 0.33/2 nM), 1000-fold selectivity over other methyltransferases and other non-epigenetic targets.		Histone Methyltransferase
T9742	SETDB1-TTD-IN-1		Histone Methyltransferase
	SETDB1-TTD-IN-1 is a potent, selective and endogenous binder competitive inhibitor of SETDB1-TTD with a Kd of 88 nM.		Histone Methyltransferase
T3520	Setipiprant	KYTH-105,ACT-129968	GPR , Prostaglandin Receptor
	Setipiprant (ACT-129968) is an orally available, selective CRTH2 antagonist (IC50: 6.0 nM). CRTH2 is a G protein-coupled receptor for prostaglandin (PGD2). PGD2 is produced by the mast cells and is a key mediator in vari...		GPR , Prostaglandin Receptor
T14526	Bemesetron	TROPANYL 3,5-DICHLOROBENZOATE,3-TROPANYL-3,5-DICHLOROBENZOATE,MDL 72222	5-HT Receptor
	Bemesetron (MDL 72222) is a selective antagonist of 5-HT3 (IC50 = 0.33 nM) with neuroprotective effects.		5-HT Receptor
T28934	Felcisetrag	TD 8954,TD8954,TD-8954	5-HT Receptor
	Felcisetrag (TD-8954) is a potent and selective orally active 5-HT4 agonist with gastrointestinal prokinetic properties.Felcisetrag shows high affinity for the human recombinant 5-HT4(c) (h5-HT4(c)) receptor with a pKi o...		5-HT Receptor
T17285	Zatosetron maleate	LY 277359 maleate	5-HT Receptor
	Zatosetron maleate（LY 277359 maleate） is a potent and selective serotonin 5HT3 receptor antagonist for the study of acute migraine.		5-HT Receptor
T22313	Dolasetron Mesylate	Anzemet hydrate,MDL-73147EF	Others , 5-HT Receptor
	Dolasetron Mesylate (MDL-73147EF) is an antagonist of the 5-HT3 receptor and can be used in research on the treatment of vomiting and nausea following chemotherapy.		Others , 5-HT Receptor
TN6930	5-Desmethylsinensetin		Others
	5-Desmethylsinensetin is a natural product.		Others
T67849	O-Desethyl Dapagliflozin	Empagliflozin-4	SGLT
	O-Desethyl Dapagliflozin (Empagliflozin-4) is a SGLT2 inhibitor, IC50=33nM.		SGLT
T11039	Didesethyl chloroquine	Bisdesethylchloroquine	Drug Metabolite
	Didesethyl chloroquine (Bisdesethylchloroquine) is an effective myocardial inhibitor. Didesethyl chloroquine (Bisdesethylchloroquine) is the main metabolite of the antimalarial drug chloroquine.		Drug Metabolite
T34624	Setileuton	MK0633,MK 0633,MK-0633	Lipoxygenase
	Setileuton (MK0633) is a specific 5-LOX inhibitor and can be used in research on asthma and atherosclerosis.		Lipoxygenase
T27020L	Isomer-Cilansetron		Others
	isomer-Cilansetron is an isomer of Cilansetron.		Others
T28537	Ricasetron	Brl 46470,Brl46470,Brl-46470	5-HT Receptor
	Ricasetron (Brl 46470) is a 5-HT3 receptor antagonist with pro-axonal lysis and antiemetic properties, and is used in the study of anxiety and anxiety disorders.		5-HT Receptor
T2S0223	Isosinensetin	6-Demethoxynobiletin	Antioxidant , HIV Protease , Antibacterial , P-gp
	1. Isosinensetin (6-Demethoxynobiletin) shows antioxidant and HIV-1 protease inhibiting activities.		Antioxidant , HIV Protease , Antibacterial , P-gp
TN1727	Helichrysetin		Apoptosis , HIV Protease
	Helichrysetin has mild anti-HIV-1 PR activity. Helichrysetin has great potentials for development as an anticancer agent, it has cytotoxic effect on four selected cancer cell lines, A549, MCF-7, Ca Ski, and HT-29.		Apoptosis , HIV Protease