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Bemesetron

Catalog No. T14526   CAS 40796-97-2
Synonyms: TROPANYL 3,5-DICHLOROBENZOATE, 3-TROPANYL-3,5-DICHLOROBENZOATE, MDL 72222

Bemesetron (MDL 72222) is a selective antagonist of 5-HT3 (IC50 = 0.33 nM) with neuroprotective effects.

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Bemesetron Chemical Structure
Bemesetron, CAS 40796-97-2
Pack Size Availability Price/USD Quantity
10 mg In stock $ 50.00
25 mg In stock $ 64.00
50 mg In stock $ 86.00
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Purity: 97.37%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Bemesetron (MDL 72222) is a selective antagonist of 5-HT3 (IC50 = 0.33 nM) with neuroprotective effects.
Targets&IC50 5-HT3 receptor:0.33 nM
In vitro In primary cortical neuronal cells, Bemesetron (1 μM) significantly blocks the H2O2-induced increase of caspase-3 immunoreactivity. Bemesetron (0.01, 0.1 and 1 μM) and Y25130 (0.05, 0.5 and 5 μM) concentration-dependently reduce the H2O2-induced decrease showing inhibition of 74.9 and 79.0% with 1 μM and 5 μM, respectively[2].
In vivo In male adult albino mice, Bemesetron (1 mg/kg; i.p.) causes a significant reduction of catalepsy, while Bemesetron (10 mg/kg; i.p.) significantly potentiates the phenomenon. The maximum inhibition of catalepsy (about 75%) occurs at 120 min, and the maximum potentiation (about 4.5-times the control value) occurs at 60 min after Haloperidol[3].
Synonyms TROPANYL 3,5-DICHLOROBENZOATE, 3-TROPANYL-3,5-DICHLOROBENZOATE, MDL 72222
Molecular Weight 314.21
Formula C15H17Cl2NO2
CAS No. 40796-97-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 2 mg/mL (6.37 mM), sonification is recommended.

TargetMolReferences and Literature

1. Peters JA, et al. An electrophysiological investigation of the properties of 5-HT3 receptors of rabbit nodose ganglion neurones in culture. Br J Pharmacol. 1993 Oct;110(2):665-76. 2. Lee HJ, et al. Blockade of 5-HT(3) receptor with MDL7222 and Y25130 reduces hydrogen peroxide-induced neurotoxicity in cultured rat cortical cells. Life Sci. 2005 Dec 5;78(3):294-300. 3. Silva SR, et al. Effects of 5-HT3 receptor antagonists on neuroleptic-induced catalepsy in mice. Neuropharmacology. 1995 Jan;34(1):97-9.

Related compound libraries

This product is contained In the following compound libraries:
Neuronal Signaling Compound Library Bioactive Compound Library Anti-Cancer Compound Library Neurotransmitter Receptor Compound Library Bioactive Compounds Library Max Inhibitor Library

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Keywords

Bemesetron 40796-97-2 GPCR/G Protein Neuroscience 5-HT Receptor TROPANYL 3,5-DICHLOROBENZOATE MDL-72222 3-TROPANYL-3,5-DICHLOROBENZOATE MDL 72222 MDL72222 inhibitor inhibit

 

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