store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Zatosetron maleate(LY 277359 maleate) is a potent and selective serotonin 5HT3 receptor antagonist for the study of acute migraine.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 700.00 | |
5 mg | In stock | $ 1,800.00 |
Description | Zatosetron maleate(LY 277359 maleate) is a potent and selective serotonin 5HT3 receptor antagonist for the study of acute migraine. |
In vivo | Acute administration of Zatosetron maleate (Zatosetron) at doses of 0.1 (n=21) and 0.3 (n=5) mg/kg in male rats, but not at doses of 0.01, 0.05, 1.0, or 10 mg/kg (n=5, 3, 6, and 4, respectively) Zatosetron maleate or saline (n=5), results in a significant reduction in the number of spontaneously active A10 dopamine cells. The number of spontaneously active A10 dopamine cells is not significantly different from 30 to 60 min post i.p. Zatosetron maleate (0.1 mg/kg) administration, shows a significant decrease by 60 to 90 min (0.65±0.11, P=0.03, n=5), a larger decrease by 90 to120 min (0.53±0.08, P=0.004, n=5), and remains at this significantly decreased level from 2 to 3 h (0.50+0.05, P=0.0004, n=5). Single-unit recordings demonstrate that Zatosetron maleate inhibits the activity of A10 dopamine cells following i.v. administration (ED50=0.12 mg/kg, n=8). Chronic administration of 0.1 mg/kg (n=16) Zatosetron maleate, but not 0.01, 1.0, or 10 mg/kg (n=4, 8, and 7, respectively) Zatosetron maleate or saline (n=5), leads to a significant reduction in the number of spontaneously active A10 dopamine cells[1]. |
Synonyms | LY 277359 maleate |
Molecular Weight | 464.94 |
Formula | C23H29ClN2O6 |
CAS No. | 123482-23-5 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
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Zatosetron maleate 123482-23-5 GPCR/G Protein Neuroscience 5-HT Receptor Zatosetron Maleate LY 277359 Maleate LY277359 Maleate LY 277359 maleate LY-277359 Maleate inhibitor inhibit