sclc — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T11882	Pulrodemstat benzenesulfonate	LSD1-IN-7 benzenesulfonate,CC-90011 benzenesulfonate	Histone Demethylase
	Pulrodemstat benzenesulfonate (CC-90011 benzenesulfonate) is a potent and orally active inhibitor of lysine specific demethylase-1 (LSD1) with anticancer activity.		Histone Demethylase
T1602	Valproic acid sodium salt	Sodium Valproate	Mitophagy , Gamma-secretase , HIV Protease , GABA Receptor , HDAC , Autophagy
	Valproic acid sodium salt (Sodium Valproate) is the sodium salt form of valproic acid with anti-epileptic activity. Valproic acid sodium salt is converted into its active form, valproate ion, in blood. Although the mecha...
T20168	Aurothiomalate sodium	Myocrisin,Myocrisine,Miochrysin,Sodium aurothiomalate,Myochrysine,gold sodium thiomalate	Others , PKC
	Sodium aurothiomalate is a gold compound that is used for its immunosuppressive anti-rheumatic effects. Aurothiomalate sodium (Miochrysin) is a potent and selective inhibitor of oncogenic PKC-ι signaling. Aurothiomalate ...		Others , PKC
T6474	Divalproex Sodium	Valproate semisodium,Epival	HDAC
	Divalproex Sodium (Valproate semisodium) binds to and inhibits gamma-aminobutyric acid (GABA) transaminase and its anticonvulsant activity may be exerted by increasing brain concentration of GABA and by inhibiting enzyme...		HDAC
T7064	Valproic Acid	Sodium valproate,2-Propylpentanoic Acid,VPA,Depakine,2-Propylvaleric Acid	Mitophagy , Gamma-secretase , HIV Protease , GABA Receptor , Sodium Channel , HDAC , Autophagy
	Valproic Acid (2-Propylpentanoic Acid) is an HDAC inhibitor that inhibits HDAC1 activity, induces HDAC2 degradation, and is orally active. Valproic Acid can be used in epilepsy and bipolar disorder research.
T14685	BMS-986158		Epigenetic Reader Domain
	BMS-986158 is a highly effective BET inhibitor, demonstrating IC50 values of 6.6 nM in NCI-H211 small cell lung cancer (SCLC) cells and 5 nM in MDA-MB231 triple negative breast cancer (TNBC) cells.		Epigenetic Reader Domain
T76698	Rovalpituzumab		Gamma-secretase
	Rovalpituzumab is a humanized monoclonal antibody targeting delta-like protein 3 (DLL3). Rovalpituzumab can be used to synthesize antibody-active molecule conjugates (ADCs). Rovalpituzumab has anticancer activity and is ...		Gamma-secretase
T67934	MRT-2359		Others
	MRT-2359 is a potent and orally available GSPT1 reducer with antitumour activity.MRT-2359 inhibits the growth of drug-resistant non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) cells.MRT-2359 exhibits...		Others
T5S0506	Rotundic acid	Rutundic acid	Apoptosis , Others , p38 MAPK , Akt , mTOR
	Rotundic acid (Rutundic acid), a natural compound, exhibit cytotoxic activities toward human hepatocellular carcinoma (HepG2), malignant melanoma (A375), SCLC (NCI-H446), breast cancer (MCF-7), and colon cancer (HT-29) c...		Apoptosis , Others , p38 MAPK , Akt , mTOR
T3062	WIKI4		PARP , Wnt/beta-catenin
	WIKI4 is a potent inhibitor of Wnt/β-catenin signaling and tankyrase 2 (TNKS2).		PARP , Wnt/beta-catenin
T71620	IBAP-II
	iBAP-II represses neuroendocrine lineage-specific ASCL1/MYCL/E2F signaling in SCLC cell lines, and dramatically inhibits SCLC cell viability and tumor growth in vivo.
T28999	TPC-144	TPC144,TPC 144
	TPC-144 is a potent and selective LSD1 inhibitor with a reversible inhibition mechanism. TPC-144 has antitumor activity in several human AML and SCLC cell lines and xenograft models.
T4134L	OTS514	OTS514 HCl,OTS514 Hydrochloride,OTS-514,OTS 514	Apoptosis , TOPK
	OTS514 (OTS514 Hydrochloride) is a potent TOPK inhibitor. OTS514 exhibits a growth-suppressive effect on small cell lung cancer. OTS514 effectively suppressed the growth of SCLC cell lines (IC50: 0.4 ~ 42.6 nM). Treatmen...		Apoptosis , TOPK
T76899	Adebrelimab
	Adebrelimab (SHR-1316), a humanized IgG4 monoclonal antibody targeting PD-L1 (PD-1/PD-L1), exhibits promising antitumor activity, notably in solid tumors and extensive-stage small-cell lung cancer (SCLC) [1] [2].
T39258	Pulrodemstat	LSD1-IN-7,CC-90011
	Pulrodemstat (CC-90011) is a highly potent and selective inhibitor of lysine specific demethylase-1 (LSD1). It exhibits a reversible mode of action and can be administered orally. With an impressive IC50 of 0.25 nM, Pulr...
T76986	Tarlatamab
	Tarlatamab (AMG-757) is a first-in-class, high-affinity, bispecific T-cell engager (BiTE) antibody that selectively targets delta-like ligand 3 (DLL3), a protein predominantly expressed in small-cell lung cancer (SCLC) t...