Powder: -20°C for 3 years | In solvent: -80°C for 1 year
OTS514 (OTS514 Hydrochloride) is a potent TOPK inhibitor. OTS514 exhibits a growth-suppressive effect on small cell lung cancer. OTS514 effectively suppressed the growth of SCLC cell lines (IC50: 0.4 ~ 42.6 nM). Treatment with OTS514 suppressed forkhead box protein M1 (FOXM1) activity. OTS514 treatment reduced CD90-positive SCLC cells and showed a higher cytotoxic effect against lung sphere-derived CSC-like SCLC cells.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
2 mg | 5 days | $ 89.00 | |
5 mg | 5 days | $ 155.00 | |
10 mg | 5 days | $ 269.00 | |
1 mL * 10 mM (in DMSO) | 5 days | $ 169.00 |
Description | OTS514 (OTS514 Hydrochloride) is a potent TOPK inhibitor. OTS514 exhibits a growth-suppressive effect on small cell lung cancer. OTS514 effectively suppressed the growth of SCLC cell lines (IC50: 0.4 ~ 42.6 nM). Treatment with OTS514 suppressed forkhead box protein M1 (FOXM1) activity. OTS514 treatment reduced CD90-positive SCLC cells and showed a higher cytotoxic effect against lung sphere-derived CSC-like SCLC cells. |
Targets&IC50 | TOPK:2.6 nM (IC50) |
Synonyms | OTS514 HCl, OTS514 Hydrochloride, OTS-514, OTS 514 |
Molecular Weight | 364.46 |
Formula | C21H20N2O2S |
CAS No. | 1338540-63-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 90 mg/mL (246.94 mM), Sonification is recommended.
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
OTS514 1338540-63-8 Apoptosis MAPK TOPK cancer OTS514 HCl multiple arrest cycle myeloma HMCL inhibit positive OTS514 Hydrochloride OTS 514 Hydrochloride OTS-514 Hydrochloride Inhibitor cell OTS-514 OTS 514 inhibitor