Search Result

Search Results for " rac1 "

Targets

Compounds

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
TP2131L	Rac1 Inhibitor W56 acetate(1095179-01-3 free base)		Rho
	Rac1 Inhibitor W56 acetate(1095179-01-3 free base) is a peptide comprising residues 45-60 of the guanine nucleotide exchange factor (GEF) recognition/activation site of Rac1. Rac1 Inhibitor W56 acetate(1095179-01-3 free ...		Rho
T61448	AZA1	Rac1/Cdc42-IN-1	Apoptosis , Rho , CDK
	AZA1 (Rac1/Cdc42-IN-1) is a potent dual inhibitor of Rac1 and Cdc42. AZA1 induced apoptosis of prostate cancer cells and inhibited cell proliferation, migration and invasion.		Apoptosis , Rho , CDK
T6342	NSC 23766 trihydrochloride	Rac1 Inhibitor,NSC 23766	Apoptosis , Rho , Ras
	NSC 23766 trihydrochloride (Rac1 Inhibitor) is an inhibitor of Rac GTPase targeting Rac activation by GEFs (IC50: ~50 μM); no inhibitory for the closely related targets, RhoA or Cdc42.		Apoptosis , Rho , Ras
TP2131	Rac1 Inhibitor W56
	Rac1 Inhibitor W56 is a peptide comprising residues 45-60 of the guanine nucleotide exchange factor (GEF) recognition/activation site of Rac1. Rac1 Inhibitor W56 selectively inhibits Rac1 interaction with Rac1-specific G...
TP2130L	Rac1 Inhibitor F56, control peptide acetate	Rac1 Inhibitor F56, control peptide acetate(1315378-77-8 free base)	Rho
	Rac1 Inhibitor F56, control peptide acetate is a control peptide version of Rac1 Inhibitor; comprises residues 45-60 of Rac1 with Trp56 replaced by Phe. Does not affect GEF-Rac1 interaction.		Rho
TP2130	Rac1 Inhibitor F56, control peptide
	Control peptide version of Rac1 Inhibitor; comprises residues 45-60 of Rac1 with Trp56 replaced by Phe. Does not affect GEF-Rac1 interaction.
T79869	Rac1-IN-3		Ras
	Rac1-IN-3 (Compound 2) is a Rac1 inhibitor exhibiting an inhibitory concentration 50 (IC50) of 46.1 μM [1].		Ras
T8527	CPYPP		Others
	CPYPP is an inhibitor of DOCK2-Rac1 interaction. CPYPP binds to DOCK2 DHR-2 domain and inhibits the guanine nucleotide exchange factor (GEF) activity of DOCK2DHR-2 for Rac1 in a dose-dependent manner(IC50 : 22.8 µM). CPY...		Others
T75932	Rac1 Inhibitor W56 TFA
	Rac1 Inhibitor W56 TFA, a peptide comprised of residues 45-60 of Rac1, selectively obstructs Rac1's interaction with the guanine nucleotide exchange factors TrioN, GEF-H1, and Tiam [1].
T22991	ML-099		Rho , Ras
	pan activator of Ras-related GTPases		Rho , Ras
T2427	EHop-016	EHop 016	Rho , Ras
	EHop-016 is a specific Rac GTPase inhibitor with IC50 of 1.1 μM for Rac1 in MDA-MB-231 and MDA-MB-435 cells, equally effective inhibition for Rac3.		Rho , Ras
T21970	ML-097		GTPase
	ML-097 (CID-2160985) is a pan activator of Ras-related GTPases		GTPase
T6483	EHT 1864	EHT 1864 2HCl	Rho , Ras
	EHT 1864 is a effective Rac family GTPase inhibitor for Rac1/Rac1b/Rac2/Rac3 (Kd: 40/50/60/250 nM).		Rho , Ras
T24833	ZINC69391	ZINC-69391,ZINC 69391,N'-(4,6-dimethylpyrimidin-2-yl)-N-[2-(trifluoromethyl)phenyl]guanidine,CysHHC10 acetate(1408311-03-4 free base)	Apoptosis , Rho
	ZINC69391 (CysHHC10 acetate(1408311-03-4 free base)) is a selective inhibitor of Rac1 with antiproliferative and antimetastatic effects. ZINC69391 interferes with the interaction of Rac1 with Dock180, reduces Rac1-GTP le...		Apoptosis , Rho
T25450	GGTI 2147	GGTI2147,Geranylgeranyl transferase inhibitor-2147,GGTI-2147	NF-κB , Rho
	GGTI 2147 decreased Rac1 activity, down-regulated p65 expression, and ameliorated OGD/R-induced neuronal apoptosis.		NF-κB , Rho
T37113	Z62954982	ZINC08010136	Rho
	Z62954982 (ZINC08010136) is a selective inhibitor of Rac1, which stunts the growth and branching of neurons.Z62954982 inhibits Rac1 activation and reduces proliferation, p38 phosphorylation, and IL-6 levels in pulmonary ...		Rho
T14004	1A-116		Rho
	1A-116 is a specific inhibitor of Rac1 .		Rho
T1237	Azathioprine	BW 57-322	Apoptosis , GPR , Rho
	Azathioprine (BW 57-322), an immunosuppressive agent, inhibits purine synthesis and GTP-binding protein Rac1 activation.		Apoptosis , GPR , Rho
T12452	Digeranyl bisphosphonate	DGBP	Rho , Ras
	Digeranyl bisphosphonate (DGBP) is a potent geranylgeranyl pyrophosphate (GGPP) synthase inhibitor that inhibits geranyl pyrophosphorylation of Rac1.Digeranyl bisphosphonate induces autophagy but not apoptosis.		Rho , Ras
T15602	ITX3		Others , Rho
	ITX3 is a specific, non-toxic, active and selective TrioN RhoGEF inhibitor with IC50 of 76 μM. ITX3 has anticancer effects, inhibits trion mediated GTP exchange on RhoG and Rac1, inhibits NGF-mediated neurite growth in P...		Others , Rho
T16745	Rhosin hydrochloride		Apoptosis , Rho , Ras
	Rhosin hydrochloride is an effective and specific RhoA subfamily Rho GTPases inhibitor, which specifically binds to RhoA to inhibit RhoA-GEF interaction (Kd: ~ 0.4 uM). Rhosin hydrochloride does not interact with Cdc42 o...		Apoptosis , Rho , Ras
T22106	MLS-573151		CDK , Ras
	MLS-573151 is a selective inhibitor of GTPase Cdc42(EC50 of 2 μM). It is inactive against other GTPases family members, such as Rab2, Rab7, H-Ras, Rac1, Rac 2 and RhoA wild-type. MLS-573151 acts by blocking the binding...		CDK , Ras
T71627	CX-5011		Casein Kinase
	CX-5011, a CK2 inhibitor, induces Rac1 activation and promotes apoptosis, effectively causing cancer cell death [1] [2].		Casein Kinase
T16746	Rhosin		Rho
	Rhosin is an effective and specific RhoA subfamily Rho GTPases inhibitor, which specifically binds to RhoA to inhibit RhoA-GEF interaction (Kd: ~ 0.4 uM). Rhosin does not interact with Cdc42 or Rac1, nor the GEF, LARG. R...		Rho
T4047L	Bisantrene HCl	CL216942,CL-216942,NSC-337766,CL 216942
	Bisantrene (CL-216942; NSC 337766) is a topoisomerase II poison and DNA intercalator. It can be used as a Rac1 inhibitor or model compound to study P-glycoprotein-mediated multi-drug resistance (MDR1). Bisantrene inserts...
T81754	MP6	Myr-FEEERA-OH	Integrin
	mP6 (Myr-FEEERA-OH), a myristoylated peptide, selectively inhibits Gα 13's interaction with integrin β 3 while preserving talin-dependent integrin function. Additionally, mP6 impedes the GTPase activity of Rac1, Rap1, an...		Integrin

Compounds

Rac1 Inhibitor W56 acetate(1095179-01-3 free base)

Synonym: Rac1/Cdc42-IN-1

Target: Apoptosis, Rho, CDK

NSC 23766 trihydrochloride

T6342

Synonym: Rac1 Inhibitor,NSC 23766

Target: Apoptosis, Rho, Ras

Rac1 Inhibitor F56, control peptide acetate

TP2130L

Synonym: Rac1 Inhibitor F56, control peptide acetate(1315378-77-8 free base)

Target: Rho

Rac1 Inhibitor F56, control peptide

Rac1 Inhibitor W56 TFA

Synonym: EHT 1864 2HCl

Target: Rho, Ras

ZINC69391

T24833

Synonym: ZINC-69391,ZINC 69391,N'-(4,6-dimethylpyrimidin-2-yl)-N-[2-(trifluoromethyl)phenyl]guanidine,CysHHC10 acetate(1408311-03-4 free base)

Target: Apoptosis, Rho

GGTI 2147

T25450

Synonym: GGTI2147,Geranylgeranyl transferase inhibitor-2147,GGTI-2147

Target: NF-κB, Rho

Z62954982

T37113

Synonym: ZINC08010136

Target: Apoptosis, GPR, Rho

Digeranyl bisphosphonate

Target: Apoptosis, Rho, Ras

Target: Casein Kinase

Synonym: CL216942,CL-216942,NSC-337766,CL 216942

Target:

mP6

T81754

Synonym: Myr-FEEERA-OH

Target: Integrin

Cat No.	Product Name	Synonyms	Targets
T5S1981	Alpha-Cyperone	(+)-α-Cyperone,α-Cyperone	Others , Endogenous Metabolite
	1. alpha-Cyperone (α-Cyperone) is a promising inhibitor of Hla production by S. aureus and protects lung cells from this bacterium. 2. alpha-Cyperone significantly inhibited PGE2 production by suppressing the LPS-induced...		Others , Endogenous Metabolite

Natural Products

alpha-Cyperone

T5S1981

Synonym: (+)-α-Cyperone,α-Cyperone

Target: Others, Endogenous Metabolite

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPH-00004	RAC1 Protein, Human, Recombinant (His)	Human	P. pastoris (Yeast)
	RAC1 Protein, Human, Recombinant (His) is expressed in yeast with C-6xHis tag. The predicted molecular weight is 24.6 kDa; 30 kDa, reducing conditions and the accession number is P63000.
TMPY-01187	Rac1 Protein, Human, Recombinant (GST)	Human	Baculovirus Insect Cells
	RAC1 is a GTPase that belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal re...
TMPY-03180	Ribonuclease A Protein, Human, Recombinant (His)	Human	HEK293 Cells
	RNase A, also known as ribonuclease A and RNASE1, belongs to ribonuclease A superfamily. It is a pancreatic-type of secretory ribonuclease. RNase A is a basic protein and its many positive charges are consistent with its...
TMPH-02580	CHRAC1 Protein, Mouse, Recombinant (His & Myc)	Mouse	E. coli
	Forms a complex with DNA polymerase epsilon subunit POLE3 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome remodeling activity of ISWI/SNF2H and ACF1. Does not enhance nucleosome sl...
TMPH-02473	14-3-3 zeta/delta Protein, Mouse, Recombinant (His & SUMO)	Mouse	E. coli
	Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine moti...
TMPY-02439	Rac2 Protein, Human, Recombinant (His)	Human	E. coli
	Ras-related C3 botulinum toxin substrate 2 (Rac2) is a small G-protein belonging to the Ras subfamily of the GTPase family. Rac2 acts as an "on / off" switch for signal transduction cascades and motilities. When GDP is a...
TMPH-01256	Dystonin Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	Cytoskeletal linker protein. Acts as an integrator of intermediate filaments, actin and microtubule cytoskeleton networks. Required for anchoring either intermediate filaments to the actin cytoskeleton in neural and musc...
TMPH-01257	Dystonin Protein, Human, Recombinant (His)	Human	P. pastoris (Yeast)
	Cytoskeletal linker protein. Acts as an integrator of intermediate filaments, actin and microtubule cytoskeleton networks. Required for anchoring either intermediate filaments to the actin cytoskeleton in neural and musc...
TMPY-04443	NEK3 Protein, Mouse, Recombinant (His & GST)	Mouse	Baculovirus Insect Cells
	NEK3 (NIMA (never in mitosis gene a)-related expressed kinase 3), contains 1 protein kinase domain and is a member of the NimA (never in mitosis A) family of serine/threonine protein kinases. Members of the NEK family of...
TMPY-04397	PAK-3 Protein, Human, Recombinant (His)	Human	Baculovirus Insect Cells
	PAK3 is a member of PAK proteins, a family of serine/threonine p21-activating kinases, serve as effectors of small Rho GTPases Cdc42 and RAC and have been implicated in a wide range of biological activities. There are si...
TMPY-01000	BVES Protein, Human, Recombinant (GST)	Human	E. coli
	Blood vessel epicardial substance (BVES), or POPDC1, is a tight junction-associated transmembrane protein that modulates epithelial-to-mesenchymal transition (EMT) via junctional signaling pathways. BVES plays a protecti...
TMPY-04455	PKC iota Protein, Human, Recombinant (GST)	Human	Baculovirus Insect Cells
	Protein kinase C iota type, also known as Atypical protein kinase C-lambda/iota, aPKC-lambda/iota and PRKCI, is a cytoplasm, membrane and nucleus protein which belongs to the protein kinase superfamily, AGC Ser/Thr prote...
TMPY-02191	BLNK Protein, Human, Recombinant (His)	Human	HEK293 Cells
	B-cell linker protein, also known as B-cell adapter containing a SH2 domain protein, B-cell adapter containing a Src homology 2 domain protein, Cytoplasmic adapter protein, Src homology 2 domain-containing leukocyte p...