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Azathioprine

Name: Azathioprine
Brand: TargetMol
SKU: T1237
Price: 45 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1237Cas No. 446-86-6

Alias BW 57-322

Azathioprine (BW 57-322), an immunosuppressive agent, inhibits purine synthesis and GTP-binding protein Rac1 activation.

Azathioprine

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Purity: 99.9%

Catalog No. T1237Alias BW 57-322Cas No. 446-86-6

Azathioprine (BW 57-322), an immunosuppressive agent, inhibits purine synthesis and GTP-binding protein Rac1 activation.

Pack Size	Price	Availability
500 mg	$45	In Stock
1 g	$59	In Stock
1 mL x 10 mM (in DMSO)	$50	In Stock

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Batch Information

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Purity:99.9%

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COA HNMR HPLC

Product Introduction

Bioactivity

Description	Azathioprine (BW 57-322), an immunosuppressive agent, inhibits purine synthesis and GTP-binding protein Rac1 activation.
In vitro	In murine and rat brain allografts, the combination of Azathioprine with Cyclosporin A or Prednisolone significantly enhances survival rates.
In vivo	Azathioprine inhibits Rac1 target genes in primary human CD4+ T lymphocytes, leading to apoptosis via the mitochondrial pathway. In isolated rat hepatocytes, Azathioprine depletes reduced glutathione (GSH), releases lactate dehydrogenase, and decreases cellular viability.
Synonyms	BW 57-322

Chemical Properties

Molecular Weight	277.26
Formula	C₉H₇N₇O₂S
Cas No.	446-86-6
Smiles	CN1C=NC(=C1SC1=NC=NC2=C1NC=N2)[N+]([O-])=O
Relative Density.	1.9 g/cm3

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (180.34 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.6067 mL	18.0336 mL	36.0672 mL	180.3361 mL
5 mM	0.7213 mL	3.6067 mL	7.2134 mL	36.0672 mL
10 mM	0.3607 mL	1.8034 mL	3.6067 mL	18.0336 mL
20 mM	0.1803 mL	0.9017 mL	1.8034 mL	9.0168 mL
50 mM	0.0721 mL	0.3607 mL	0.7213 mL	3.6067 mL
100 mM	0.0361 mL	0.1803 mL	0.3607 mL	1.8034 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc