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1A-116

1A-116
1A-116 is a specific Rac1 inhibitor.
Catalog No. T14004Cas No. 1430208-73-3
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Purity:98.43%
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1A-116

Catalog No. T14004Cas No. 1430208-73-3
1A-116 is a specific Rac1 inhibitor.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
1 mg$29In Stock
5 mg$68In Stock
10 mg$113In Stock
25 mg$227In Stock
50 mg$341In Stock
100 mg$489In Stock
200 mg$678In Stock
1 mL x 10 mM (in DMSO)$75In Stock
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Product Introduction

Bioactivity
Description
1A-116 is a specific inhibitor of Rac1 .
Targets&IC50
Antiproliferative:4 µM(F3II cell)
In vitro
1A-116 shows lesser effect on MCF7::pcDNA.3 cells than on MCF7::C1199 cells. 1A-116 treatment decreases phospho-PAK1 levels in a time-dependent manner. The presence of 1A-116 reverts the PAK1 phosphorylation induced by 4-hydroxytamoxifen (Tam). The presence of 1A-116 also effectively reverts Rac1-PAK1-mediated estrogen receptor (ER) phosphorylation at Ser305[1]. 1A-116 shows a significant increase in antiproliferative activity on F3II cells, showing an IC50 value of 4 μM. A-116 also dramatically impairs Rac1 activation at low micromolar range (1 μM)[2].
In vivo
Daily treatment of mice with compound 1A-116 at 3mg/kg body weight/day reduces about 60% the formation of total metastatic lung colonies. A significant antitumor activity is obtained for macronodules (more than 1 mm in diameter) by treatment with 1A-116 in this highly aggressive breast cancer model. The treatment with 1A-116 reduces the total lung weight compare to the control group, leading to a total weight similar to the average pulmonary weight of Balb/c mice[2].
Chemical Properties
Molecular Weight307.31
FormulaC16H16F3N3
Cas No.1430208-73-3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 100 mg/mL (325.40 mM), Sonication is recommended.
H2O: < 0.1 mg/mL (insoluble)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.2540 mL16.2702 mL32.5404 mL162.7022 mL
5 mM0.6508 mL3.2540 mL6.5081 mL32.5404 mL
10 mM0.3254 mL1.6270 mL3.2540 mL16.2702 mL
20 mM0.1627 mL0.8135 mL1.6270 mL8.1351 mL
50 mM0.0651 mL0.3254 mL0.6508 mL3.2540 mL
100 mM0.0325 mL0.1627 mL0.3254 mL1.6270 mL

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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