nadph-oxidase — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T4359	VAS2870		NADPH
	VAS2870 is an inhibitor of NADPH oxidase (NOX).		NADPH
T8107	GLX351322		NADPH-oxidase , NADPH
	GLX351322 is NADPH Oxidase 4 Inhibitor with IC50 of 5 μM.		NADPH-oxidase , NADPH
T8408	GKT136901	AK120765	NADPH-oxidase , NADPH
	GKT136901 (AK120765) is an inhibitor of NOX1/4.It acts as Selective and Direct Scavenger of Peroxynitrite		NADPH-oxidase , NADPH
T7042	1,5-Isoquinolinediol		PARP
	1, 5-Isoquinolinediol is an inhibitor of poly(ADP-ribose) synthetase (PARP1; IC50: 0.39 μM). The poly(ADP-ribose) polymerases (PARPs) form a family of enzymes with roles in DNA repair and apoptosis. 1, 5-Isoquinolinediol...		PARP
T15433	GSK2795039		Apoptosis , Reactive Oxygen Species , ROS , NADPH
	GSK2795039 inhibits reactive oxygen species (ROS) production and NADPH consumption. GSK2795039 decreases apoptosis. GSK2795039 is an inhibitor of NADPH oxidase 2 (NOX2) (pIC50: 6 in different cell-free assays).		Apoptosis , Reactive Oxygen Species , ROS , NADPH
T6099	Setanaxib	GKT137831	NADPH-oxidase , Ferroptosis , NADPH
	Setanaxib (GKT137831) is a potent, specific dual NADPH oxidase (NOX1/4) inhibitor.		NADPH-oxidase , Ferroptosis , NADPH
T22990	ML-090	Fluoflavine	NADPH-oxidase , Others
	ML-090 is NOX1-specific inhibitor(IC50 = 90 nM) which is >100 selectivity for NOX1 over NOX2, NOX3, NOX4 (all IC50s >10 μM).		NADPH-oxidase , Others
T7191	Diphenyleneiodonium chloride	DPI	NOS , Reactive Oxygen Species , NADPH , TRP/TRPV Channel
	Diphenyleneiodonium chloride (DPI)(DPI) is an irreversible inhibitor of iNOS and eNOS (IC50 values of 50 nM and 0.3 μM, respectively),and displays broad-spectrum bactericidal activity.		NOS , Reactive Oxygen Species , NADPH , TRP/TRPV Channel
T10353	APX-115 free base	Ewha-18278 free base	NADPH-oxidase , NADPH
	APX-115 free base (Ewha-18278 free base) (Ewha-18278 free base) is a potent, orally active pan NADPH oxidase (Nox) inhibitor (Kis: 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2, and Nox4). APX-115 effectively prevents kid...		NADPH-oxidase , NADPH
T6391	Apocynin	Acetovanillone,Acetoguaiacone,NSC 2146	Apoptosis , NADPH , Autophagy
	Apocynin (NSC 2146) is a specific NADPH-oxidase inhibitor (IC50: 10 μM).		Apoptosis , NADPH , Autophagy
T38423	CL097	CL097	Reactive Oxygen Species , TLR
	CL097 is an effective agonist of TLR7 and TLR8. CL097 induces pro-inflammatory cytokines in macrophages and NADPH oxidase priming, thereby increasing the fMLF-stimulated ROS production.		Reactive Oxygen Species , TLR
TN2126	Quercetin-3-O-glucose-6''-acetate	6"-O-Acetylisoquercitrin	NADPH-oxidase , ROS , NADPH
	Quercetin-3-O-glucose-6''-acetate (6"-O-Acetylisoquercitrin) is an inhibitor of NADPH oxidase. Quercetin-3-O-glucose-6''-acetate has antioxidant activities.		NADPH-oxidase , ROS , NADPH
T83625	INOS-IN-14	3-bromo-1H-indazole-7-carbonitrile	NOS
	iNOS-IN-14 (3-bromo-1H-indazole-7-carbonitrile) is a potent nitric oxide synthase (NOS) inhibitor that inhibits the NADPH oxidase activity of nNOS.		NOS
T29097	VAS 3947	VA-S3947,VA S3947,VAS3947	Apoptosis , NADPH-oxidase
	VAS 3947 is a specific inhibitor of NADPH oxidase (NOX).VAS 3947 has a potent anti-platelet effect, inducing apoptosis through UPR activation, mainly due to protein aggregation and misfolding, independent of anti-NOX act...		Apoptosis , NADPH-oxidase
TP1886L1	NoxA1ds acetate(1435893-78-9 free base)		NADPH-oxidase
	NoxA1ds acetate is a potent and selective NADPH oxidase 1 (NOX1) inhibitor (IC50 : 20 nM). Exhibits selectivity for NOX1 over NOX2, NOX4, NOX5 and xanthine oxidase. Inhibits NOX1-derived O2- production in HT-29 human col...		NADPH-oxidase
T22096	L 012 sodium salt
	L 012 sodium salt, a luminol analogue, is a widely used chemiluminescent (CL) probe for active oxygen and active nitrogen. L 012 sodium salt is widely used to detect the superoxides (O2•−) derived from NADPH oxidase (Nox...
T10354	APX-115	Ewha-18278	NADPH-oxidase
	APX-115 (Ewha-18278) (Ewha-18278) is a potent, orally active pan NADPH oxidase (Nox) inhibitor (Kis: 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2, and Nox4). APX-115 effectively prevents kidney injury.		NADPH-oxidase
T15300	Fluorofenidone	AKF-PD	Others
	Fluorofenidone (AKF-PD) attenuates the progression of renal interstitial fibrosis partly by suppressing NADPH oxidase and extracellular matrix (ECM) deposition via the PI3K/Akt signalling pathway. Fluorofenidone is an an...		Others
T13112	Tat-NR2B9c	Tat-NR2Bct,NA-1	NO Synthase , iGluR
	Tat-NR2B9c (NA-1) is a postsynaptic density-95 (PSD-95) inhibitor with neuroprotective and antiepileptic effects.Tat-NR2B9c inhibits PSD-95d2, PSD-95d1, and PSD-95, which prevents the activation of NMDA-induced NADPH oxi...		NO Synthase , iGluR
T5S2343	Acetylshikonin	Acetyl shikonin	Others , P450 , AChE
	1. Acetylshikonin exhibits weak cytotoxicity against human umbilical vein endothelial cells (HUVECs) with IC5 of over 2 microM, exhibits the antiangiogenic and antitumorigenic effects by suppressing proliferation and ang...		Others , P450 , AChE