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Catalog No. T4359   CAS 722456-31-7

VAS2870 is an inhibitor of <a href="/target/NADPH" style="display: inline; color: #c13a36">NADPH</a> oxidase (NOX).

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VAS2870, CAS 722456-31-7
Pack Size Availability Price/USD Quantity
5 mg In stock $ 64.00
10 mg In stock $ 114.00
25 mg In stock $ 213.00
50 mg In stock $ 381.00
100 mg In stock $ 678.00
200 mg In stock $ 829.00
1 mL * 10 mM (in DMSO) In stock $ 71.00
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Purity: 98%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description VAS2870 is an inhibitor of NADPH oxidase (NOX).
In vitro VAS2870 blocks serum-dependent cell growth of FaO rat hepatoma cells. VAS2870 inhibits the proliferation of different human hepatocellular carcinoma (HCC) cell lines. VAS2870 pretreatment enhances TGF-b-mediated apoptosis of FaO rat hepatoma cells. VAS2870 is effective to suppress PDGF-BB-dependent activation of NADPH oxidase and subsequent production of intracellular ROS. Moreover, VAS2870 suppresses PDGF-BB-dependent chemotaxis, but not DNA synthesis. Preincubation with VAS2870 (10 and 20 μM) completely abolishes PDGF-mediated NADPH oxidase activation and ROS production. Preincubation with VAS2870 (0.1-20 μM) does not affect PDGF-induced cell cycle progression. However, it abolishes PDGF-dependent chemotaxis of VSMC in a concentration-dependent manner (100% inhibition at 10 μM). VAS2870 inhibits dose-dependently autocrine increase of cell number in FaO rat hepatoma cells, and almost completely blocked ROS production and thymidine incorporation when used at 25 mM.
Molecular Weight 360.4
Formula C18H12N6OS
CAS No. 722456-31-7


Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 83.3 mg/mL (231.14 mM), Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. ten Freyhaus H, et al. Novel Nox inhibitor VAS2870 attenuates PDGF-dependent smooth muscle cell chemotaxis, but not proliferation. Cardiovasc Res. 2006 Jul 15;71(2):331-41. 2. Sancho P, et al. The NADPH oxidase inhibitor VAS2870 impairs cell growth and enhances TGF-β-induced apoptosis of liver tumor cells. Biochem Pharmacol. 2011 Apr 1;81(7):917-24.

Related compound libraries

This product is contained In the following compound libraries:
Preclinical Compound Library Metabolism Compound Library Bioactive Compounds Library Max Inhibitor Library Anti-Aging Compound Library Lipid Metabolism Compound Library Anti-Cancer Metabolism Compound Library Anti-Cardiovascular Disease Compound Library Glycometabolism Compound Library NO PAINS Compound Library

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VAS2870 722456-31-7 Metabolism NADPH NADPH Oxidase VAS 2870 NOX inhibit Inhibitor VAS-2870 inhibitor