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VAS2870

Catalog No. T4359 CAS 722456-31-7

VAS2870 is an inhibitor of <a href="/target/NADPH" style="display: inline; color: #c13a36">NADPH</a> oxidase (NOX).

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

VAS2870, CAS 722456-31-7

Pack Size	Availability	Price/USD
5 mg	In stock	$ 64.00
10 mg	In stock	$ 114.00
25 mg	In stock	$ 213.00
50 mg	In stock	$ 381.00
100 mg	In stock	$ 678.00
200 mg	In stock	$ 829.00
1 mL * 10 mM (in DMSO)	In stock	$ 71.00

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

VAS2870 is an inhibitor of NADPH oxidase (NOX).

In vitro

VAS2870 blocks serum-dependent cell growth of FaO rat hepatoma cells. VAS2870 inhibits the proliferation of different human hepatocellular carcinoma (HCC) cell lines. VAS2870 pretreatment enhances TGF-b-mediated apoptosis of FaO rat hepatoma cells. VAS2870 is effective to suppress PDGF-BB-dependent activation of NADPH oxidase and subsequent production of intracellular ROS. Moreover, VAS2870 suppresses PDGF-BB-dependent chemotaxis, but not DNA synthesis. Preincubation with VAS2870 (10 and 20 μM) completely abolishes PDGF-mediated NADPH oxidase activation and ROS production. Preincubation with VAS2870 (0.1-20 μM) does not affect PDGF-induced cell cycle progression. However, it abolishes PDGF-dependent chemotaxis of VSMC in a concentration-dependent manner (100% inhibition at 10 μM). VAS2870 inhibits dose-dependently autocrine increase of cell number in FaO rat hepatoma cells, and almost completely blocked ROS production and thymidine incorporation when used at 25 mM.

Molecular Weight	360.4
Formula	C18H12N6OS
CAS No.	722456-31-7

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 83.3 mg/mL (231.14 mM), Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. ten Freyhaus H, et al. Novel Nox inhibitor VAS2870 attenuates PDGF-dependent smooth muscle cell chemotaxis, but not proliferation. Cardiovasc Res. 2006 Jul 15;71(2):331-41. 2. Sancho P, et al. The NADPH oxidase inhibitor VAS2870 impairs cell growth and enhances TGF-β-induced apoptosis of liver tumor cells. Biochem Pharmacol. 2011 Apr 1;81(7):917-24.

Related compound libraries

This product is contained In the following compound libraries：

Preclinical Compound Library Metabolism Compound Library Bioactive Compounds Library Max Inhibitor Library Anti-Aging Compound Library Lipid Metabolism Compound Library Anti-Cancer Metabolism Compound Library Anti-Cardiovascular Disease Compound Library Glycometabolism Compound Library NO PAINS Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

VAS2870 722456-31-7 Metabolism NADPH NADPH Oxidase VAS 2870 NOX inhibit Inhibitor VAS-2870 inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.