Shopping Cart
- Remove All
Your shopping cart is currently empty
VAS2870
🥰Excellent
Catalog No. T4359Cas No. 722456-31-7
VAS2870 is an inhibitor of NADPH oxidase (NOX).
VAS2870
🥰Excellent
Purity: 97.49%
Catalog No. T4359Cas No. 722456-31-7
VAS2870 is an inhibitor of NADPH oxidase (NOX).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $52 | In Stock | |
| 10 mg | $98 | In Stock | |
| 25 mg | $189 | In Stock | |
| 50 mg | $345 | In Stock | |
| 100 mg | $516 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $58 | In Stock |
Bulk & Custom
Add to Cart
Questions
View MoreInhibitors Related to "VAS2870"
Triclosan
Cited
Irgasan, Cloxifenolum
T13143380-34-5
Triclosan (Irgasan) is an antibacterial and antifungal agent.
- $41
Size
QTY
CitedAKR1C1-IN-1
T141514906-68-7
AKR1C1-IN-1 is a human 20α-hydroxysteroid dehydrogenase (AKR1C1) inhibitor (Ki: 4 nM for AKR1C1).
- $44
Size
QTY
Metronidazole Cited
Metronidazol, Flagyl, Anagiardil
T1079443-48-1
Metronidazole (Metronidazol) is a synthetic nitroimidazole derivative with antiprotozoal and antibacterial activities.
- $30
Size
QTY
CitedASP-9521
ASP9521
T45291126084-37-4
ASP-9521 is a selective, potent and orally active indole-based AKR1C3 inhibitor with an IC50 of 11 nM for human AKR1C3.
- $33
Size
QTY
Resveratrol
Cited
trans-Resveratrol, SRT 501
T1558501-36-0
Resveratrol (SRT 501) is a polyphenolic natural product, a plant antitoxin with antioxidant and chemopreventive activities. Resveratrol has a wide range of targets including COX, SIRT, LOC, etc. Resveratrol induces autophagy and apoptosis.
AntibacterialAntibioticAntifungalApoptosisAutophagyCOXDNA/RNA SynthesisIκB/IKKLipoxygenaseMitophagyNADPHNrf2Sirtuin
- $36
Size
QTY
CitedPasiniazid
Pasiniazide, Paraniazide, Isonicotinic acid hydrazide p-aminosalicylate
T04412066-89-9
Pasiniazid (Paraniazide) is an anti-TB and anti-leprosy drug.
- $42
Size
QTY
Dicoumarol
Dicumarol
T080966-76-2
Dicoumarol (Dicumarol) is a hydroxycoumarin originally isolated from molding sweet-clover hay, with anticoagulant and vitamin K depletion activities. Dicoumarol is a competitive inhibitor of vitamin K epoxidereductase; thus, it inhibits vitamin K recycling and causes depletion of active vitamin K in blood. This prevents the formation of the active form of prothrombin and several other coagulant enzymes, and inhibits blood clotting.
- $41
Size
QTY
Apocynin Cited
NSC 2146, Acetovanillone, Acetoguaiacone
T6391498-02-2
Apocynin (NSC 2146) is a specific NADPH-oxidase inhibitor (IC50: 10 μM).
- $50
Size
QTY
CitedCarvedilol phosphate hemihydrate
Carvedilol phosphate, BM 14190 (phosphate hemihydrate)
T0342610309-89-2
Carvedilol phosphate hemihydrate (BM 14190 phosphate hemihydrate) is the phosphate salt form of carvedilol, a racemic mixture and adrenergic blocking agent with antihypertensive activity and no intrinsic sympathomimetic activity.
- $31
Size
QTY
Setanaxib
GKT137831
T60991218942-37-0
Setanaxib (GKT137831) is a potent, specific dual NADPH oxidase (NOX1/4) inhibitor.
- $34
Size
QTY
HTS07545
T61316118666-03-8
HTS07545 is a potent sulfide:quinone oxidoreductase inhibitor (IC50: 30 nM) that reduces the rate of hydrogen sulfide (H2S) decomposition and has been used in heart failure studies.
- $38
Size
QTY
NAD+ Cited
β-Nicotinamide Adenine Dinucleotide, β-NAD, β-DPN, DPN, Cozymase
T160953-84-9
NAD+ (β-Nicotinamide Adenine Dinucleotide) is a coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH).
- $41
Size
QTY
CitedSelect Batch
Purity:97.49%
Contact us for more batch information
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | VAS2870 is an inhibitor of NADPH oxidase (NOX). |
| In vitro | VAS2870 effectively inhibits the growth and proliferation of FaO rat hepatoma cells and various human hepatocellular carcinoma (HCC) cell lines, while also enhancing TGF-b-mediated apoptosis in these cells. It suppresses the activation of NADPH oxidase and the production of intracellular ROS induced by PDGF-BB, without affecting DNA synthesis. Preincubation with VAS2870 at concentrations of 10 and 20 μM completely prevents PDGF-mediated NADPH oxidase activation and ROS production, although it does not interfere with PDGF-induced cell cycle progression. However, VAS2870 does effectively eliminate PDGF-dependent chemotaxis of VSMC, achieving 100% inhibition at 10 μM. Additionally, VAS2870 dose-dependently reduces autocrine cell number increases in FaO rat hepatoma cells, and at 25 mM, it almost completely blocks ROS production and thymidine incorporation. |
| Molecular Weight | 360.39 |
| Formula | C18H12N6OS |
| Cas No. | 722456-31-7 |
| Smiles | C(c1ccccc1)n1nnc2c(Sc3nc4ccccc4o3)ncnc12 |
| Relative Density. | 1.53 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 83.3 mg/mL (231.14 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
| ||||||||||||||||||||||||||||||||||||
Sci Citations
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Preview
Related Tags: buy VAS2870 | purchase VAS2870 | VAS2870 cost | order VAS2870 | VAS2870 chemical structure | VAS2870 in vitro | VAS2870 formula | VAS2870 molecular weight
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2025 TargetMol Chemicals Inc. All Rights Reserved.