Powder: -20°C for 3 years
In solvent: -80°C for 2 years
VAS2870 is an inhibitor of <a href="/target/NADPH" style="display: inline; color: #c13a36">NADPH</a> oxidase (NOX).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 64.00 | |
10 mg | In stock | $ 114.00 | |
25 mg | In stock | $ 213.00 | |
50 mg | In stock | $ 381.00 | |
100 mg | In stock | $ 678.00 | |
200 mg | In stock | $ 829.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 71.00 |
Description | VAS2870 is an inhibitor of NADPH oxidase (NOX). |
In vitro | VAS2870 blocks serum-dependent cell growth of FaO rat hepatoma cells. VAS2870 inhibits the proliferation of different human hepatocellular carcinoma (HCC) cell lines. VAS2870 pretreatment enhances TGF-b-mediated apoptosis of FaO rat hepatoma cells. VAS2870 is effective to suppress PDGF-BB-dependent activation of NADPH oxidase and subsequent production of intracellular ROS. Moreover, VAS2870 suppresses PDGF-BB-dependent chemotaxis, but not DNA synthesis. Preincubation with VAS2870 (10 and 20 μM) completely abolishes PDGF-mediated NADPH oxidase activation and ROS production. Preincubation with VAS2870 (0.1-20 μM) does not affect PDGF-induced cell cycle progression. However, it abolishes PDGF-dependent chemotaxis of VSMC in a concentration-dependent manner (100% inhibition at 10 μM). VAS2870 inhibits dose-dependently autocrine increase of cell number in FaO rat hepatoma cells, and almost completely blocked ROS production and thymidine incorporation when used at 25 mM. |
Molecular Weight | 360.4 |
Formula | C18H12N6OS |
CAS No. | 722456-31-7 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
DMSO: 83.3 mg/mL (231.14 mM), Need ultrasonic
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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VAS2870 722456-31-7 Metabolism NADPH NADPH Oxidase VAS 2870 NOX inhibit Inhibitor VAS-2870 inhibitor