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Apocynin

Catalog No. T6391   CAS 498-02-2
Synonyms: Acetovanillone, Acetoguaiacone, NSC 2146

Apocynin (NSC 2146) is a specific NADPH-oxidase inhibitor (IC50: 10 μM).

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Apocynin Chemical Structure
Apocynin, CAS 498-02-2
Pack Size Availability Price/USD Quantity
1 g In stock $ 50.00
1 mL * 10 mM (in DMSO) In stock $ 50.00
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Purity: 99.98%
Purity: 99.71%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Apocynin (NSC 2146) is a specific NADPH-oxidase inhibitor (IC50: 10 μM).
Targets&IC50 NADPH-oxidase:10 μM
In vitro Apocynin demonstrates anti-inflammatory activity by reducing neutrophil infiltration, the extent of spinal cord injury, the formation of PAR and nitrotyrosine, and the expression of ICAM-1 and P-selectin. It inhibits the degradation of IκB-α, activation of NF-κB, and apoptosis (as indicated by TUNEL staining, FAS ligand, Bax, and Bcl-2 expression), and the production of pro-inflammatory cytokines (TNF-α and IL-1β) and the activation of MAPK pathways (P-38 and phosphorylated-JNK). The LD50 in mice is 9 g/kg (p.o.). Apocynin is effective in various inflammatory cells and animal models. It attenuates the production of TNF-α and IL-1β, and the expression of iNOS in the lungs of mice treated with carrageenan. Moreover, apocynin offers beneficial effects in mouse models of spinal cord injury.
In vivo Upon metabolic transformation, Apocynin can inhibit the assembly of NADPH oxidase, possibly due to the production of reactive oxygen species (ROS). It achieves this by inhibiting the serine phosphorylation of p47phox and disrupting its interaction with gp91phox, thereby inactivating NADPH oxidase activity. Furthermore, Apocynin reduces the generation of superoxide (O(2)(-)) in activated macrophages and neutrophils.
Source
Synonyms Acetovanillone, Acetoguaiacone, NSC 2146
Molecular Weight 166.17
Formula C9H10O3
CAS No. 498-02-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 16.6 mg/mL (100 mM)

Ethanol: 16.6 mg/mL (100 mM)

TargetMolReferences and Literature

1. Stolk J,et al. Am J Respir Cell Mol Biol, 1994, 11(1), 95-102. 2. Simons JM, et al. Free Radic Biol Med, 1990, 8(3), 251-258. 3. Stefanska J, et al. Mediators Inflamm, 2008, 106507. 4. Impellizzeri D, et al. Biochem Pharmacol, 2011, 81(5), 636-648. 5. Impellizzeri D, et al. Free Radic Res, 2011, 45(2), 221-236. 6. Deng Zheng, Fei Shi, Zheng Zhou, Feng Sun, Menghao Sun, Qian Sun, Lei Chen et al. M1 macrophage mediated increased reactive oxygen species (ROS) influence wound healing via the MAPK signaling in vitro and in vivo [J]. Toxicology and Applied Pharmacology. 2019 Mar 1;366:83-95.

TargetMolCitations

1. Deng Z, Shi F, Zhou Z, et al. M1 macrophage mediated increased reactive oxygen species (ROS) influence wound healing via the MAPK signaling in vitro and in vivo. Toxicology and Applied Pharmacology. 2019, 366: 83-95

Related compound libraries

This product is contained In the following compound libraries:
Miao medicine Compound Library Tobacco Monomer Library The Yao nationality medicine Library Lipid Metabolism Compound Library Natural Product Library for HTS NO PAINS Compound Library Traditional Mongolian Medicine Compound Library ReFRAME Related Library Anti-Fibrosis Compound Library Anti-COVID-19 Traditional Chinese Medicine Compound Library

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Keywords

Apocynin 498-02-2 Apoptosis Autophagy Metabolism NADPH Acetovanillone Acetoguaiacone inhibit NSC2146 NSC 2146 Inhibitor NSC-2146 inhibitor

 

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