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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T1887 | Inauhzin | INZ | Sirtuin |
Inauhzin (INZ)(INZ) is a novel small molecule that effectively reactivates p53 by inhibiting SIRT1 activity, promotes p53-dependent apoptosis of human Y cells without causing apparently genotoxic stress(IC50=3 uM, in A54... | |||
T16523L | PhiKan 083 | Mdm2 | |
PhiKan 083 is a carbazole derivative | |||
T21578 | NSC 66811 | Mdm2 | |
NSC 66811is a novel inhibitor of the murine double minute 2 (MDM2)-p53 interaction. It binds to MDM2 with a Ki of 120 nM and activates p53 in cancer cells with a mechanism of action consistent with targeting the MDM2-p53... | |||
T1873 | Tenovin-3 | Tenovin3 | Sirtuin |
Tenovin-3 acts as a p53 activator. | |||
T8774 | MS7972 | Epigenetic Reader Domain | |
MS7972 is CREBBP inhibitor that blocks human p53 and CREB binding protein association. MS7972 can almost completely block this BRD interaction at 50 μM | |||
T2464 | ZMC1 | p53 | |
NSC-319726 (ZMC1), a mutant p53R175 reactivator, suppresses growth of fibroblasts that expresses the p53R175 mutation (IC50 = 8 nM). | |||
T6910 | NSC59984 | p53 | |
NSC59984, a p53 pathway activator, induces mutant p53 protein degradation and p73 activation. | |||
T27029 | Cjoc42 | cjoc 42,cjoc-42 | |
Cjoc42 is an inhibitor of gankyrin, an ankyrin-repeat oncoprotein whose overexpression has been implicated in the development of many cancer types. cjoc42 prevents the decrease in p53 protein levels normally associated w... | |||
T6610 | XI-006 | NSC 207895 | Mdm2 , p53 |
XI-006 (XI-006) suppresses MDMX with IC50 of 2.5 μM, leading to enhanced p53 stabilization/activation and DNA damage, and also regulates MDM2, an E3 ligase. | |||
T12257 | NSC 146109 hydrochloride | Apoptosis , Others | |
NSC 146109 hydrochloride is an activator of p53 targeting MDMX. NSC 146109 hydrochloride can be used for studies on breast cancer. | |||
T9698 | UC2288 | Mdm2 , p53 | |
UC2288 is a relatively selective p21 attenuator which is synthesized based Sorafenib. UC2288 attenuates p21 protein levels with minimal effect on p21 protein stability. | |||
T7703 | PK11007 | Reactive Oxygen Species , p53 | |
PK11007 is an anti-p53 drug. | |||
T4325 | COTI-2 | COTI 2,COTI2 | Apoptosis , p53 |
COTI-2, an orally available thiosemicarbazone, is an activator of mutant forms of the p53 protein with potential antineoplastic activity. | |||
T24730 | Roslin 2 bromide | Roslin-2,Benzylhexamethylenetetramine bromide,Roslin2 | FAK , p53 |
Roslin 2 bromide (Benzylhexamethylenetetramine bromide) is a p53 reactivator that disrupts the binding of FAK and p5. Roslin 2 bromide exhibits anticancer effects. | |||
T21773 | SP-141 | SP 141 | Mdm2 |
SP 141 is a MDM2 inhibitor.SP-141 promotes MDM2 auto-ubiquitination and degradation, with anticancer activity. | |||
T1818 | Tenovin-6 | Tenovin 6 | Dehydrogenase , Sirtuin , Autophagy |
Tenovin-6 is a p53 transcriptional activity agonist. | |||
T1919 | Tenovin-1 | Tenovin 1 | Mdm2 , Dehydrogenase , Sirtuin , p53 , Autophagy |
Tenovin-1 inhibits protein-deacetylating activities of SirT1 and SirT2 and protects against MDM2-mediated p53 degradation, which involves ubiquitination. | |||
T8480 | Tenovin-6 Hydrochloride | Dehydrogenase , Sirtuin , HDAC , p53 , Autophagy | |
Tenovin-6 Hydrochloride is an SIRT1, SIRT2 and HDAC8 inhibitor(IC50s of 21 μM, 10 μM, and 67 μM for SirT1, SirT2, and SirT3, respectively), and is also a potent p53 activator . | |||
T4414 | Eprenetapopt | APR-246,PRIMA-1Met | Apoptosis , Others , Ferroptosis , p53 , Autophagy |
Eprenetapopt (PRIMA-1Met) restores wild-type conformation and function to mutant p53, and triggers apoptosis in tumor cells. PRIMA-1MET also targets the selenoprotein thioredoxin reductase 1 (TrxR1), a key regulator of c... | |||
T6210 | Pifithrin-μ | PFTμ,NSC 303580,2-Phenylethynesulfonamide | HSP , p53 , Autophagy |
Pifithrin-μ (NSC-303580) is an inhibitor of p53 and HSP70, with neuroprotective and antitumor activity. |