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Search Results for " mcl "

Targets

Compounds

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
TP1889	MCL0020	MCL 0020	Melanocortin Receptor
	MCL0020 is a potent and selective melanocortin MC4 receptor antagonist (IC50 values are 11.63, 1115 and > 10 000 nM at MC4, MC3 and MC1 receptors respectively). Significantly reverses stress-induced anorexia but has no e...		Melanocortin Receptor
T12041	MIM1	Inhibitor of Mcl-1	BCL
	MIM1 (Inhibitor of Mcl-1) is an myeloid cell factor 1 (Mcl-1) inhibitor.		BCL
T11967	Mcl-1 antagonist 1		Others
	Mcl-1 antagonist 1 is a Mcl-1 protein antagonist.		Others
T40230	Mcl-1 inhibitor 6
	Mcl-1 inhibitor 6 is a potent, orally active chemical compound that selectively inhibits the myeloid cell leukemia 1 (Mcl-1) protein, with a high affinity (K d = 0.23 nM) and binding activity (K i = 0.02 μM). This compou...
T11972	Mcl-1 inhibitor 3		BCL
	Mcl-1 inhibitor 3 shows good pharmacokinetic properties and excellent in vivo efficacy without toxicity.Mcl-1 inhibitor 3 is a highly potent and orally activate macrocyclic Mcl-1 inhibitor (Ki= 0.061 nM; IC50=19 nM in an...		BCL
T11971	MCL-1/BCL-2-IN-4		Others
	MCL-1/BCL-2-IN-4 is a selective and potent Mcl-1 and Bcl-2 dual inhibitor.		Others
T11968	MCL-1/BCL-2-IN-1		BCL
	MCL-1/BCL-2-IN-2 (Compound Nap-1) is a potent and selective dual inhibitor of Mcl-1 and Bcl-2 with IC 50 s of 4.45 and 3.18 μM, respectively [1].		BCL
T11969	MCL-1/BCL-2-IN-2		Others
	MCL-1/BCL-2-IN-2 is a potent and selective Bcl-2 and Mcl-1 dual inhibitor.		Others
T11970	MCL-1/BCL-2-IN-3		Others
	MCL-1/BCL-2-IN-3 is a selective and potent Mcl-1 and Bcl-2 dual inhibitor with IC50s of 5.95 and 4.78 μM, respectiely.		Others
T27997	MDK-3345	MDK 3345,Mcl-1 Inhibitor11,Mcl-1 Inhibitor 11,Mcl-1 Inhibitor-11
	MDK-3345 is a reversible covalent inhibitor for Mcl-1.
T27986	MCL0129	MCL-0129,MCL 0129
	MCL0129, a selective and non-peptidergic melanocortin 4 (MC4) receptor antagonist, is a potential treatment for cachexia.
T72610	Mcl-1 inhibitor 9
	Mcl-1 Inhibitor 9 (Example 2) is a potent inhibitor of myeloid cell leukemia 1 (Mcl-1), demonstrating anti-tumor activity with an IC50 value of 0.21889 nM.
T79036	Mcl-1 inhibitor 13
	Mcl-1 Inhibitor 13 (Example 9), with a Ki of 8.2 nM, serves as an MCL-1 inhibitor suitable for cancer research [1].
T27996	MDK-3298	Mcl-1 Inhibitor-5,Mcl-1 Inhibitor 5,MDK3298,Mcl-1 Inhibitor5
	MDK-3298 is a reversible covalent inhibitor of Mcl-1, a target of protein-protein interaction (PPI).
T75143	Mcl-1 inhibitor 12
	Mcl-1 Inhibitor 12 (Example 10), with a K i of 0.22 nM, functions as an MCL-1 inhibitor. It is utilized in cancer research [1].
T79215	Mcl-1 inhibitor 14
	Compound (Ra)-10, also known as Mcl-1 inhibitor 14, is a potent inhibitor of myeloid cell leukemia-1 (MCL-1), exhibiting a K_i of 0.018 nM, and holds potential for use in anticancer research [1].
T79216	Mcl-1 inhibitor 15
	Mcl-1 Inhibitor 15 (Compound (Ra)-15), with a K i of 0.02 nM, is utilized in cancer research [1].
T79242	Mcl-1 inhibitor 16
	Mcl-1 Inhibitor 16 (Compound 9), a platinum-based mitochondrial-targeting agent, inhibits Mcl-1 and induces Bax/Bak-dependent apoptosis in cancer cells. This compound exhibits antitumor activity and may be utilized as a ...
T62443	Bcl-2/Mcl-1-IN-2
	Bcl-2/Mcl-1-IN-2 is a Bcl-2 (Ki: 4.70 μM) and Mcl-1 (Ki: 0.88 μM) inhibitor.Bcl-2/Mcl-1-IN-2 can be used in cancer research.
T62249	Bcl-2/Mcl-1-IN-1
	Bcl-2/Mcl-1-IN-1 is an inhibitor of Bcl-2 (Ki: 4.53 μM) and Mcl-1 (Ki: 1.19 μM).Bcl-2/Mcl-1-IN-1 can be used in cancer research.
T62941	Bcl-2/Mcl-1-IN-3
	Bcl-2/Mcl-1-IN-3 is a Bcl-2/Mcl-1 inhibitor that acts on Mcl-1 (Ki: 0.14 μM) and Bcl-2 (Ki: 0.23 μM) and can be used in cancer research.
T10096L	Voruciclib		CDK
	Voruciclib is an orally active and selective CDK inhibitor (Ki: 0.626 nM-9.1 nM). Voruciclib represses the expression of MCL-1 in multiple models of diffuse large B-cell lymphoma. Voruciclib effectively blocks CDK9, the ...		CDK
T18487	NH2-C6-NH-Boc		Others , PROTAC Linker
	NH2-C6-NH-Boc is a PROTAC linker. NH2-C6-NH-Boc can be used in the synthesis the Mcl-1 inhibitor based on PROTAC.		Others , PROTAC Linker
T11976	Mcl1-IN-4		Others
	Mcl1-IN-4 is an inhibitor of Mcl1 ( IC50:0.2 μM).		Others
T68398	MI-223
	MI-223 is an inhibitor of Mcl-1-stimulated homologous recombination (HR) DNA repair, which leads to sensitization of cancer cells to hydroxyurea- or olaparib-induced DNA replication stress.
T16156	MT 63-78		Apoptosis , AMPK , mTOR
	MT 63-78 is a specific and effective direct AMPK activator (EC50: 25 μM). MT 63-78 blocks prostate cancer growth by inhibiting the lipogenesis and mTORC1 pathways. MT 63-78 has antitumor effects. MT 63–78 also causes cel...		Apoptosis , AMPK , mTOR
T16030	Mcl1-IN-8		Others
	Mcl1-IN-8 is an Mcl-1-PUMA interface inhibitor (Ki: 0.3 μM). In cancer cells, Mcl1-IN-8 shows dual activity on reducing PUMA-dependent apoptosis while deactivating Mcl-1-mediated anti-apoptosis.		Others
T11977	Mcl1-IN-9		BCL
	Mcl1-IN-9 is a potent myeloid cell leukemia-1 (Mcl-1) Inhibitor with an IC50 of 446 nM in reengineered BCR-ABL+ B-ALL cells and a Ki of 0.03 nM.		BCL
T11974	Mcl1-IN-12		BCL
	Mcl1-IN-12 has anti-tumor activity.It is a selective Mcl-1 inhibitor, less potent at Bcl-2, with Kis of 0.29 and 3.1 μM, respectively.		BCL
T11973	Mcl1-IN-11		BCL
	Mcl1-IN-11 (Compound G) is a selective Mcl-1 inhibitor, less potent at Bcl-2, with Kis of 0.06 and 4.2 μM, respectively.		BCL
T16029	Mcl1-IN-3		Others
	Mcl1-IN-3 is an Mcl1 inhibitor. It has an IC50 and Ki of 0.67 and 0.13 μM, respectively.		Others
T16027	Mcl1-IN-1		Others
	Mcl1-IN-1 is a myeloid cell factor 1 inhibitor (IC50=2.4 µM).		Others
T24436	Mcl1-IN-26
	Mcl1-IN-26 is an effective and selective myeloid cell leukemia 1 inhibitor.
T11975	PROTAC Mcl1 degrader-1		BCL
	PROTAC Mcl1 degrader-1 induces the ubiquitination and proteasomal degradation of Mcl-1 by introducing the E3 ligase cereblon (CRBN)-binding ligand pomalidomide to Mcl-1 inhibitor S1-6 with μM-range affinity. PROTAC Mcl1 ...		BCL
T2558	Cladribine	2-chlorodeoxyadenosine,2-Chloro-2′-deoxyadenosine,CldAdo,2CdA	Apoptosis , Adenosine deaminase
	Cladribine (2CdA), an adenosine deaminase inhibitor, is utilized in the treatment of lymphoproliferative diseases.		Apoptosis , Adenosine deaminase
T16028	IMB-XH1	Mcl1-IN-2	BCL , Antibacterial
	IMB-XH1 (Mcl1-IN-2) is a myeloid cell factor 1 (Mcl-1) inhibitor.		BCL , Antibacterial
T24812	SOMCL-863
	SOMCL-863 is a selective and orally bioavailable c-Met inhibitor. It shows antitumor activity both in vitro and in vivo.
T19024	MCLA hydrochloride		Others
	MCLA hydrochloride, a chemiluminescent compound, can be used to quantify aqueous concentrations of superoxide.		Others
T13657	DMCL1-2		Others
	dMCL1-2 is a potent and selective myeloid leukemia 1 (MCL1) degrading agent based on PROTAC, which binds to MCL1 with a KD of 30 nM. dmcl-2 activates the apoptosis mechanism by degrading MCL1.		Others
T2632	A-1210477		Apoptosis , BCL
	A-1210477 is an effective and specific MCL-1 and Bcl-2 inhibitor (Ki/IC50: 0.454/26.2 nM).		Apoptosis , BCL
T5108	ML311		BCL
	ML311 is a selective inhibitor of the Mcl-1/Bim interaction.		BCL
T6034	UMI-77	UMI77,UMI 77	BCL
	UMI-77, a specific Mcl-1 inhibitor (Ki: 490 nM), has selectivity over other members of Bcl-2 family.		BCL
T17247	VU0661013	VU661013	BCL
	VU0661013 is an effective and selective inhibitor of MCL-1.		BCL
T6281	TW-37	TW 37	BCL
	TW-37 is an nonpeptide inhibitor to recombinant Bcl-2, Bcl-xL and Mcl-1 (Ki: 0.29/1.11/0.26 μM).		BCL
T6396	(R)-(-)-Gossypol acetic acid	(-)-Gossypol acetic acid,AT-101 (acetic acid),(R)-Gossypol acetic acid,AT101,AT101 acetate	BCL , Autophagy
	(R)-(-)-Gossypol acetic acid (AT101 acetate) , the R-(-) enantiomer of Gossypol acetic acid, binds with Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.32 μM, 0.48 μM and 0.18 μM; does not inhibit BIR3 domain and BID. Phase 2.		BCL , Autophagy
T6650	Sabutoclax	BI-97C1	BCL
	Sabutoclax (BI-97C1)(BI-97C1) is a pan-Bcl-2 inhibitor, including Bcl-xL, Bcl-2, Mcl-1 and Bfl-1 with IC50 of 0.31 μM, 0.32 μM, 0.20 μM and 0.62 μM, respectively.		BCL
T11944	Maritoclax	Marinopyrrole A	BCL
	Maritoclax (Marinopyrrole A) (Marinopyrrole A) is a novel and specific Mcl-1 inhibitor, shows >8 fold selectivity than BCL-xl (IC50 > 80 μM),with an IC50 value of 10.1 μM.		BCL
T14665L	Motixafortide TFA(664334-36-5,Free)	TF 14016 TFA,BKT140 TFA,BL-8040 TFA,T140 TFA	CXCR
	Motixafortide TFA(664334-36-5,Free) (BKT140 TFA) is an antagonist of CXCR4 with IC50 of ～1 nM. It induces the apoptosis of AML blasts by down-regulating ERK, BCL-2, MCL-1 and cyclin-D1 via altered miR-15a/16-1 expression...		CXCR
T13639	Deferasirox (Fe3+ chelate)		Apoptosis
	Deferasirox (Fe3+ chelate) is an orally available iron chelator with potential anticancer activity, inhibits the anti-apoptotic activity of MCL-1, and can be used to study iron overload.		Apoptosis
T5346	S63845		BCL
	S63845 is a selective MCL-1 inhibitor(Kd: 0.19 nM)		BCL

Compounds

MCL0020

TP1889

Synonym: MCL 0020

Target: Melanocortin Receptor

MIM1

T12041

Synonym: Inhibitor of Mcl-1

Synonym: MDK 3345,Mcl-1 Inhibitor11,Mcl-1 Inhibitor 11,Mcl-1 Inhibitor-11

Target:

MCL0129

T27986

Synonym: MCL-0129,MCL 0129

Synonym: Mcl-1 Inhibitor-5,Mcl-1 Inhibitor 5,MDK3298,Mcl-1 Inhibitor5

Target: Others, PROTAC Linker

Target: Apoptosis, AMPK, mTOR

PROTAC Mcl1 degrader-1

Synonym: 2-chlorodeoxyadenosine,2-Chloro-2′-deoxyadenosine,CldAdo,2CdA

Target: Apoptosis, Adenosine deaminase

IMB-XH1

T16028

Synonym: Mcl1-IN-2

Target: BCL, Antibacterial

Target: Apoptosis, BCL

Synonym: UMI77,UMI 77

(R)-(-)-Gossypol acetic acid

T6396

Synonym: (-)-Gossypol acetic acid,AT-101 (acetic acid),(R)-Gossypol acetic acid,AT101,AT101 acetate

Target: BCL, Autophagy

Synonym: Marinopyrrole A

Target: BCL

Motixafortide TFA(664334-36-5,Free)

T14665L

Synonym: TF 14016 TFA,BKT140 TFA,BL-8040 TFA,T140 TFA

Target: CXCR

Deferasirox (Fe3+ chelate)

Cat No.	Product Name	Synonyms	Targets
T6185	Gambogic Acid	Beta-Guttiferrin,Guttatic Acid,Guttic Acid	BCL , Autophagy
	Gambogic Acid (Guttic Acid) ( EC50=0.78-1.64 uM) activates caspases. Gambogic Acid competitively suppresses Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1. The IC50s of Gambogic Acid for Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 ...		BCL , Autophagy
T5688	Micheliolide		NOS , NF-κB , COX
	Micheliolide(MCL) is a sesquiterpene lactone which inhibits various inflammatory response.		NOS , NF-κB , COX
T5668	Triacetylresveratrol	Acetyl-trans-resveratrol	BCL , NF-κB , STAT
	Triacetylresveratrol (Acetyl-trans-resveratrol) has anti-cancer activity,it inhibits the phosphorylation of STAT3 and NFκB, down-regulates Mcl-1, and up-regulates Bim and Puma in pancreatic cancer cells.		BCL , NF-κB , STAT
T2730	Gossypol (acetic acid)	(±)-Gossypol-acetic acid,Pogosin,AT101,Gossypol acetic acid	BCL
	Gossypol acetic acid (AT101), a polyphenolic compound isolated from cottonseeds, binds with Bcl-2, Bcl-xL, Mcl-1, and does not inhibit BIR3 domain and BID.		BCL
T30969	Clitocine		Apoptosis , BCL
	Clitocine, an adenosine analogue derived from mushrooms, is a potent transcriptional readout agent, an inhibitor of nonsense mutations, and has anticancer activity, inducing the production of p53 protein in cells carryin...		Apoptosis , BCL
T3824	Jaceosidin		Apoptosis , BCL , COX , UGT
	Jaceosidin has anti-oxidative activity. Jaceosidin has anti-inflammatory activity, also a microglial inhibitor with anti-neuroinflammation activity. aceosidin has anticancer activity, modulates the ERK/ATM/Chk1/2 pathway...		Apoptosis , BCL , COX , UGT

Natural Products

Gambogic Acid

T6185

Synonym: Beta-Guttiferrin,Guttatic Acid,Guttic Acid

Target: BCL, Autophagy

Micheliolide

T5688

Synonym:

Target: NOS, NF-κB, COX

Triacetylresveratrol

T5668

Synonym: Acetyl-trans-resveratrol

Target: BCL, NF-κB, STAT

Gossypol (acetic acid)

T2730

Synonym: (±)-Gossypol-acetic acid,Pogosin,AT101,Gossypol acetic acid

Target: Apoptosis, BCL

Jaceosidin

T3824

Synonym:

Target: Apoptosis, BCL, COX, UGT

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-02003	FH/Fumarate Hydratase Protein, Human, Recombinant (His)	Human	E. coli
	Fumarate Hydratase (FH) is an enzymatic component of the tricarboxylic acid (TCA) cycle, or Krebs cycle, and catalyzes the formation of L-malate from fumarate. It exists in both a cytosolic form and an N-terminal extende...
TMPY-01643	CLEC4D Protein, Human, Recombinant (His)	Human	HEK293 Cells
	CLEC4D Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 21.2 kDa and the accession number is Q8WXI8.
TMPY-02293	CD23 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	CD23 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 33.2 kDa and the accession number is P06734-1.

FH/Fumarate Hydratase Protein, Human, Recombinant (His)

TMPY-02003

Species: Human

Expression System: E. coli

CLEC4D Protein, Human, Recombinant (His)

TMPY-01643

Species: Human

Expression System: HEK293 Cells

CD23 Protein, Human, Recombinant (His)

TMPY-02293

Species: Human

Expression System: HEK293 Cells