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Mcl1-IN-1

Name: Mcl1-IN-1
Brand: TargetMol
SKU: T16027
Rating: 4.5 (1 reviews)

😃Good

Catalog No. T16027Cas No. 713492-66-1

Mcl1-IN-1 is a myeloid cell factor 1 inhibitor (IC50=2.4 μM).

Mcl1-IN-1

😃Good

Catalog No. T16027Cas No. 713492-66-1

Mcl1-IN-1 is a myeloid cell factor 1 inhibitor (IC50=2.4 μM).

Pack Size	Price	Availability
2 mg	$198	6-8 weeks
5 mg	$347	6-8 weeks
25 mg	$1,140	6-8 weeks
50 mg	$1,490	6-8 weeks
100 mg	$1,990	6-8 weeks
1 mL x 10 mM (in DMSO)	$382	6-8 weeks

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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	Mcl1-IN-1 is a myeloid cell factor 1 inhibitor (IC50=2.4 μM).
Targets&IC50	MCL1:2.4 μM
In vitro	Mcl1-IN-1 is an Mcl-1 inhibitor, which shows good Mcl-1 inhibition (IC50=2.4 μM). It also has no appreciable inhibition of Bcl-xL at 100 μM.

Chemical Properties

Molecular Weight	435.86
Formula	C₂₃H₁₈ClN₃O₄
Cas No.	713492-66-1
Relative Density.	1.455 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (114.72 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2943 mL	11.4716 mL	22.9431 mL	114.7157 mL
5 mM	0.4589 mL	2.2943 mL	4.5886 mL	22.9431 mL
10 mM	0.2294 mL	1.1472 mL	2.2943 mL	11.4716 mL
20 mM	0.1147 mL	0.5736 mL	1.1472 mL	5.7358 mL
50 mM	0.0459 mL	0.2294 mL	0.4589 mL	2.2943 mL
100 mM	0.0229 mL	0.1147 mL	0.2294 mL	1.1472 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc