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Mcl1-IN-1

Name: Mcl1-IN-1
Brand: TargetMol
SKU: T16027
Rating: 4.5 (1 reviews)

Catalog No. T16027 Copy Product Info

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Mcl1-IN-1 is a myeloid cell factor 1 inhibitor (IC50=2.4 μM).

Mcl1-IN-1

Copy Product Info

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Catalog No. T16027

Mcl1-IN-1 is a myeloid cell factor 1 inhibitor (IC50=2.4 μM).

Cas No. 713492-66-1

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Pack Size	Price	USA Stock	Global Stock
2 mg	$198	6-8 weeks	6-8 weeks
5 mg	$347	6-8 weeks	6-8 weeks
25 mg	$1,140	6-8 weeks	6-8 weeks
50 mg	$1,490	6-8 weeks	6-8 weeks
100 mg	$1,990	6-8 weeks	6-8 weeks
1 mL x 10 mM (in DMSO)	$382	6-8 weeks	6-8 weeks

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Product Introduction

Bioactivity

Description	Mcl1-IN-1 is a myeloid cell factor 1 inhibitor (IC50=2.4 μM).
Targets&IC50	MCL1:2.4 μM
In vitro	Mcl1-IN-1 is an Mcl-1 inhibitor, which shows good Mcl-1 inhibition (IC50=2.4 μM). It also has no appreciable inhibition of Bcl-xL at 100 μM.

Chemical Properties

Molecular Weight	435.86
Formula	C₂₃H₁₈ClN₃O₄
Cas No.	713492-66-1
Smiles	OC(=O)COc1ccccc1C(Nc1ccccn1)c1cc(Cl)c2cccnc2c1O
Relative Density.	1.455 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (114.72 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2.5 mg/mL (5.74 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2943 mL	11.4716 mL	22.9431 mL	114.7157 mL
5 mM	0.4589 mL	2.2943 mL	4.5886 mL	22.9431 mL
10 mM	0.2294 mL	1.1472 mL	2.2943 mL	11.4716 mL
20 mM	0.1147 mL	0.5736 mL	1.1472 mL	5.7358 mL
50 mM	0.0459 mL	0.2294 mL	0.4589 mL	2.2943 mL
100 mM	0.0229 mL	0.1147 mL	0.2294 mL	1.1472 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc