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Mcl1-IN-1

Catalog No. T16027 CAS 713492-66-1

Mcl1-IN-1 is a myeloid cell factor 1 inhibitor (IC50=2.4 μM).

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Mcl1-IN-1, CAS 713492-66-1

Pack Size	Availability	Price/USD
1 mg	5 days	$ 139.00
2 mg	5 days	$ 198.00
5 mg	5 days	$ 347.00
10 mg	5 days	$ 541.00
1 mL * 10 mM (in DMSO)	5 days	$ 382.00

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Mcl1-IN-1 is a myeloid cell factor 1 inhibitor (IC50=2.4 μM).
Targets&IC50	MCL-1:2.4 μM
In vitro	Mcl1-IN-1 is an Mcl-1 inhibitor, which shows good Mcl-1 inhibition (IC50=2.4 μM). It also has no appreciable inhibition of Bcl-xL at 100 μM.

Molecular Weight	435.86
Formula	C23H18ClN3O4
CAS No.	713492-66-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 2 years

Solubility Information

DMSO: 50 mg/mL (114.72 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Richard DJ, et al. Hydroxyquinoline-derived compounds and analoguing of selective Mcl-1 inhibitors using a functional biomarker. Bioorg Med Chem. 2013 Nov 1;21(21):6642-9.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Mcl1-IN-1 713492-66-1 Others Mcl1 IN 1 Mcl-1-IN-1 Mcl1IN1 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.