katp — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T27624	Iptakalim Hydrochloride		Potassium Channel , AChR
	Iptakalim, a lipophilic para-amino compound, is a novel ATP-sensitive potassium channel (KATP) opener, as well as an α4β2-containing nicotinic acetylcholine receptor (nAChR) antagonist. Iptakalim is also a K(ir) 6.1/SUR2...		Potassium Channel , AChR
T0075	Nicorandil	SG-75	Potassium Channel
	Nicorandil (SG-75)(Ikorel) acts by relaxing the smooth muscle of the blood vessels, especially those of the venous system. It undertakes this through two methods. Firstly, by activating potassium channels, and secondly b...		Potassium Channel
T1781	GW9508	GW 9508	GPR , Potassium Channel
	GW9508(GW 9508) is a potent and selective agonist for FFA1 (GPR40), stimulates insulin secretion in a glucose-sensitive manner.		GPR , Potassium Channel
T5391	Bepridil hydrochloride	CERM 1978	Calcium Channel
	Bepridil hydrochloride (CERM 1978) is a calcium channel blocker and also inhibits Na+/Ca2+ exchange (NCX), sodium channels and cardiac sarcolemmal KATP channels.		Calcium Channel
T29457L	5-Hydroxydecanoate sodium		Potassium Channel
	5-Hydroxydecanoate sodium is a selective ATP-sensitive K+ (KATP) channel blocker with IC50 of about 30 μM. 5-Hydroxydecanoate sodium is a substrate for mitochondrial outer membrane acyl-CoA synthetase with antioxidant p...		Potassium Channel
T15385	Glibornuride		Potassium Channel
	Glibornuride is an ATP-sensitive K+ channels (KATP channel) blocker ( pKi: 5.75). It is an antidiabetic agent.		Potassium Channel
T1603	Glipizide	CP 28720,K 4024	Potassium Channel , PPAR , ABC
	Glipizide (CP 28720) is a short-acting, second-generation sulfonylurea with hypoglycemic activity.		Potassium Channel , PPAR , ABC
TQ0150	Levcromakalim	(-)-Cromakalim,BRL 38227	Potassium Channel
	Levcromakalim (BRL 38227) is an activator of the ATP-sensitive K+ channel.		Potassium Channel
T3427	Polydatin	Piceid,Polydotin Peceid	Apoptosis , Mitophagy , NF-κB , Autophagy
	Polydatin (Piceid), the glycoside of Resveratrol, is originally isolated from the Chinese herb Polygonum cuspidatum. The compound can inhibit platelet aggregation and elevate the ratios of LDL-C/HDL-C and TC/HDL-C. In th...		Apoptosis , Mitophagy , NF-κB , Autophagy
T0451	Minoxidil	U10858	Potassium Channel , COX
	Minoxidil (U10858) is an orally administered vasodilator with hair growth stimulatory and antihypertensive effects.		Potassium Channel , COX
T6587	Mitiglinide Calcium	KAD-1229,S21403	ATPase , Potassium Channel
	Mitiglinide Calcium (KAD-1229) is a blood glucose-lowering drugs, stimulating insulin secretion by closing the ATP-sensitive K+ channels in pancreatic beta-cells.		ATPase , Potassium Channel
T3876	Loureirin B		PAI-1 , ERK , Potassium Channel , JNK
	Loureirin B can downregulate the expression of fibrosis-related molecules by regulating MMPs and TIMPs levels, inhibit scar fibroblast proliferation and suppress TGF-β1-induced fibrosis, during which TGF-β1/Smad2/3 pathw...		PAI-1 , ERK , Potassium Channel , JNK
T1634	Glibenclamide	Glyburide	Potassium Channel , Mitochondrial Metabolism , CFTR , P-gp , Autophagy
	Glibenclamide (Glyburide) is an antidiabetic sulfonylurea derivative with actions similar to those of chlorpropamide.
T1530	Mitiglinide calcium hydrate	KAD-1229 calcium hydrate,Mitiglinide calcium,S-21403 calcium hydrate	Potassium Channel
	Mitiglinide calcium hydrate (S-21403 calcium hydrate) is a drug for the treatment of type 2 diabetes. Mitiglinide is thought to stimulate insulin secretion by closing the ATP-sensitive K(+) K(ATP) channels in pancreatic ...		Potassium Channel
T15667	KRN4884		Others
	KRN 4884 is an opener of the K+ channel. KRN 4884 (0.1-3 μM) activates KATP channels in a concentration-dependent manner (EC50=0.55 μM), in the presence of intracellular ATP (1 mM).		Others
T16267	Naminidil	BMS 234303-01	Others
	Naminidil is an opener of cyanoguanidine KATP.		Others
T13949	U89232		Others
	U-89232 is an opener of the cardioselective KATP channel.		Others
T23169	PNU 37883 hydrochloride		Others
	Kir6 (KATP) channel antagonist		Others
T31627	Englitazone sodium	CP-72,467-2,D03996,CP-72467-2,Englitazone sodium (USAN)
	Englitazone sodium is an antidiabetic agent and a novel NSCA and KATP channel blocker.
T17268	Y-26763		Others
	Y-26763 is a K+ channel opener and active metabolite of Y-27152. This is an ATP-sensitive K+ (KATP) channel activator.		Others