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Glipizide

Catalog No. T1603 CAS 29094-61-9

Synonyms: K 4024, CP 28720

Glipizide is a short-acting, second-generation sulfonylurea with hypoglycemic activity.

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Glipizide, CAS 29094-61-9

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Glipizide is a short-acting, second-generation sulfonylurea with hypoglycemic activity.
Targets&IC50	KATP:6.4 nM ATP-sensitive potassium (IC50)
Kinase Assay	The activity of caspase-3, -8 and -9 is assessed using the caspase-3, -8 and -9 colorimetric assay kits, respectively. In brief, 1×106?cells in a 60-mm culture dish are incubated with 10 mM Valproic acid for 24 h. The cells are then washed in PBS and suspended in 5 volumes of lysis buffer provided with the kit. Protein concentrations are determined using the Bradford method. Supernatants containing 50 μg total protein are used to determine caspase-3, -8 and -9 activities. The supernatants are added to each well in 96-well microtiter plates with DEVD-pNA, IETD-pNA or LEHD-pNA as caspase-3, -8 and -9 substrates and the plates are incubated at 37°C for 1 h. The optical density of each well is measured at 405 nm using a microplate reader. The activity of caspase-3, -8 and -9 is expressed in arbitrary absorbance units.

Synonyms	K 4024, CP 28720
Molecular Weight	445.54
Formula	C21H27N5O4S
CAS No.	29094-61-9

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 82 mg/mL (184 mM)

Ethanol: <1 mg/mL

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Gribble FM, Ashcroft FM. Metabolism. 2000 Oct;49(10 Suppl 2):3-6.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Glipizide 29094-61-9 DNA Damage/DNA Repair Membrane transporter/Ion channel Metabolism Potassium Channel ABC PPAR type 2 diabetes sulfonylurea class K 4024 K ATP KcsA Inhibitor CP28720 CP-28720 mellitus K4024 inhibit ATP-sensitive potassium CP 28720 K-4024 pancreatic β inhibitor

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