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Bepridil hydrochloride

Catalog No. T5391 CAS 68099-86-5

Synonyms: CERM 1978

Bepridil hydrochloride (CERM 1978) is a calcium channel blocker and also inhibits Na+/Ca2+ exchange (NCX), sodium channels and cardiac sarcolemmal KATP channels.

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Bepridil hydrochloride Chemical Structure

Bepridil hydrochloride, CAS 68099-86-5

Pack Size	Availability	Price/USD
5 mg	In stock	$ 41.00
10 mg	In stock	$ 54.00
25 mg	In stock	$ 98.00
50 mg	In stock	$ 135.00
100 mg	In stock	$ 189.00
1 mL * 10 mM (in DMSO)	In stock	$ 45.00

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Purity: 99.71%

Purity: 99.45%

Biological Description

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Description	Bepridil hydrochloride (CERM 1978) is a calcium channel blocker and also inhibits Na+/Ca2+ exchange (NCX), sodium channels and cardiac sarcolemmal KATP channels.
In vitro	Bepridil (1-100 microM) inhibited the K(ATP) channel current in a concentration-dependent manner. The IC(50) value of bepridil was estimated to be 10.5 microM for outward K(ATP) channel currents (holding potential, +60 mV) and 6.6 microM for inward K(ATP) channel currents (holding potential, -60 mV). Bepridil (0.1-30 microM) also inhibited K(Na) channel currents measured at the holding potential of -60 mV, in a concentration-dependent manner with an IC(50) value of 2.2 microM [2].
In vivo	The predominant effects of Bepridil (cumulative dose = 9.0 mg/kg i.v.) in the conscious rat were reduced coronary vascular resistance and heart rate. Bepridil showed selectivity for the coronary circulation since systemic vascular resistance was not significantly reduced until cumulative i.v. dosage of 21.0 mg/kg was administered [1].

Synonyms	CERM 1978
Molecular Weight	403
Formula	C24H35ClN2O
CAS No.	68099-86-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 130 mg/mL (322.58 mM)

References and Literature

1. Flaim SF, et al. Effects of bepridil hydrochloride on cardiocirculatory dynamics, coronary vascular resistance, and cardiac output distribution in normal, conscious rats. J Cardiovasc Pharmacol. 1988 Mar;11(3):363-72. 2. Li Y, et al. Bepridil blunts the shortening of action potential duration caused by metabolic inhibition via blockade of ATP-sensitive K(+) channels and Na(+)-activated K(+) channels. J Pharmacol Exp Ther. 1999 Nov;291(2):562-8. 3. Qiu M, Li Z, Chen Y, et al. Tolcapone Potently Inhibits Seminal Amyloid Fibrils Formation and Blocks Entry of Ebola Pseudoviruses. Frontiers in Microbiology. 2020, 11: 504.

Citations

1. Qiu M, Li Z, Chen Y, et al. Tolcapone Potently Inhibits Seminal Amyloid Fibrils Formation and Blocks Entry of Ebola Pseudoviruses. Frontiers in Microbiology. 2020, 11: 504

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Drug Library Anti-Cancer Approved Drug Library Inhibitor Library Drug Repurposing Compound Library Membrane Protein-targeted Compound Library Approved Drug Library Neuronal Signaling Compound Library Bioactive Compounds Library Max Anti-Hypertension Compound Library Bioactive Compound Library

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Keywords

Bepridil hydrochloride 68099-86-5 Membrane transporter/Ion channel Metabolism Calcium Channel CERM1978 CERM 1978 inhibit Ca2+ channels Bepridil CERM-1978 Inhibitor Ca channels Bepridil Hydrochloride inhibitor

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