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Search Results for " ica "

20

Compounds

Cat No. Product Name Synonyms Targets
T15546 ICA N-[4-(2-Pyridinyl)-2-thiazolyl]-2-pyridinamine Potassium Channel , Parasite
ICA (N-[4-(2-Pyridinyl)-2-thiazolyl]-2-pyridinamine) is a SK channel inhibitor and exhibits antileishmanial activity (IC50: 2.1 µM).
T9009 ICA-105574 ICA,3-nitro-N-[4-phenoxyphenyl]-benzamide HER
ICA-105574 (ICA) is an activator of hERG that binds to the channel to remove inactivation, thus increasing peak current amplitude and shortening the action potential. It also modulates activation kinetics of the channel.
T15545 ICA-27243 Potassium Channel
ICA-27243 is less effective at activating KCNQ4 and KCNQ3/Q5. ICA-27243 is a potent and orally active KCNQ2/Q3 potassium channel opener (EC50: 0.38 μM). ICA-27243 also has antiepileptic and anticonvulsant effects.
T7612 ICA 110381 Potassium Channel
ICA 110381 is a KCNQ2/Q3 potassium channel opener for the treatment of epilepsy
T7336 ICA-121431 2,2-Diphenyl-N-[4-(thiazol-2-ylsulfamoyl Sodium Channel
ICA-121431 (2,2-Diphenyl-N-[4-(thiazol-2-ylsulfamoyl) is a nanomolar potent small molecule Nav1.7 channel inhibitor with IC50 of 19 nM for rat Nav1.7, with little or no activity against human Nav1.5 or Nav1.7 channels.
T3959 ICA-069673 ICA069673 Potassium Channel
ICA-069673 is an activator of KCNQ2/Q3 potassium channel (IC50: 0.69 μM).
T3528 Senicapoc ICA-17043 Potassium Channel
Senicapoc (ICA-17043) is a potent inhibitor of the Gardos channel and ameliorates RBC dehydration in the SAD mouse. Senicapoc blocked Ca2+-induced rubidium flux from human RBCs with an IC50 value of 11 ± 2 nM (CLT IC50 =...
T11606 ICA-105665 PF-04895162 Others
ICA-105665 (PF-04895162) is a potent and orally active neuronal Kv7.2/7.3 and Kv7.3/7.5 potassium channels opener. ICA-105665 had low cytotoxic potential in human hepatocytes but inhibited liver mitochondrial function an...
T6456 CRT0044876 NSC 69877,7-NO2-ICA,NSC 69877,7-Nitroindole-2-Carboxylic Acid DNA/RNA Synthesis
CRT0044876 (7-NO2-ICA) is a potent and selective APE1 inhibitor with IC50 of ~3 μM.
T13275 Vabicaserin hydrochloride SCA 136 5-HT Receptor
Vabicaserin hydrochloride (SCA 136) is a selective agonist of 5-hydroxytryptamine 2C (5-HT2C) receptor (EC50: 8 nM).
T21443 Prednicarbate Hoe 777,Hoe-777,Dermatop E emollient,UNII-V901LV1K7D Others
Prednicarbate (Hoe 777) is a Corticosteroid Hormone Receptor Agonist. Prednicarbate has antipruritic, anti-inflammatory, and vasoconstrictive properties. It also decreases the number of circulating lymphocytes by inhibit...
T5246 Trans-​2-​butene-​1,​4-​dicarboxylic acid trans-2-Butene-1,4-dicarboxylic Acid,3-Hexenedioic Acid,trans-3-Hexenedioic Acid,β-Hydromuconic Acid Others , Endogenous Metabolite
Trans-2-butene-1,4-dicarboxylic acid (3-Hexenedioic Acid) is a normal human unsaturated dicarboxylic acid metabolite with increased excretion in patients with Dicarboxylic aciduria caused by fatty acid metabolism disorde...
T5736 1,3-Dicaffeoylquinic acid CYNARIN,Cyclohexanecarboxyli​c acid, 1,​3-​bis[[3-​(3,​4-​dihydroxyphenyl)​-​1-​oxo-​2-​propen-​1-​yl]​oxy]​-​4,​5-​dihydroxy-​, (1S,​3R,​4R,​5R)​-,1,3-O-Dicaffeoylquinic acid,1,5-Dicaffeoylquinic acid Reactive Oxygen Species , Akt , PI3K
1,3-Dicaffeoylquinic acid (CYNARIN) is a natural product. It shows antioxidant and choleretic properties and is a potential immunosuppressive agent.
T21059 Ticagrelor metabolite M5 Ticagrelor metabolite M5,,T437700,AR-C133913XX P2Y Receptor
Ticagrelor metabolite M5 (T437700) is a metabolite of Ticagrelor, the first reversible oral antagonist of P2Y12 receptor. Compared to Clopidogrel, Ticagrelor has faster and more consistent inhibition on ADP-receptors. Ti...
T61046 Anticancer agent 43 Apoptosis
Anticancer agent 43 is a potent anticancer agent that induces apoptosis through caspase 3, PARP1, and Bax protein-dependent pathways.Anticancer agent 43 induces DNA damage and can be used in the study of glioblastoma in ...
T77707 Di-tert-butyl dicarbonate BOC anhydride Others
Di-tert-butyl dicarbonate(BOC anhydride) is a biochemical reagent that can be used in biochemical experiments.
T1727 4-Cyclohexyl-1-phenylthiosemicarbazide Others
4-Cyclohexyl-1-phenylthiosemicarbazide is employed as an intermediate.
T60272 Isatin-β-thiosemicarbazone IBT HSV
Isatin-β-thiosemicarbazone is a potent inhibitor of herpes simplex virus (HSV). isatin-β-thiosemicarbazone exhibits antiviral activity by inhibiting both HSV-1 and HSV-2. isatin-β-thiosemicarbazone is Isatin-β-thiosemica...
T6387 Ampiroxicam CP 65703,Flucam COX
Ampiroxicam (Flucam) is a nonselective cyclooxygenase inhibitor uesd as anti-inflammatory drug.
T4539 Nicainoprol RU-42924 Sodium Channel
Nicainoprol (RU-42924) is a fast-sodium-channel blocking drug. Nicainoprol is a potent antiarrhythmic agent.

Compounds

ICA
T15546
Synonym: N-[4-(2-Pyridinyl)-2-thiazolyl]-2-pyridinamine
Target: Potassium Channel, Parasite
ICA-105574
T9009
Synonym: ICA,3-nitro-N-[4-phenoxyphenyl]-benzamide
Target: HER
ICA-27243
T15545
Synonym:
Target: Potassium Channel
ICA 110381
T7612
Synonym:
Target: Potassium Channel
ICA-121431
T7336
Synonym: 2,2-Diphenyl-N-[4-(thiazol-2-ylsulfamoyl
Target: Sodium Channel
ICA-069673
T3959
Synonym: ICA069673
Target: Potassium Channel
Senicapoc
T3528
Synonym: ICA-17043
Target: Potassium Channel
ICA-105665
T11606
Synonym: PF-04895162
Target: Others
CRT0044876
T6456
Synonym: NSC 69877,7-NO2-ICA,NSC 69877,7-Nitroindole-2-Carboxylic Acid
Target: DNA/RNA Synthesis
Vabicaserin hydrochloride
T13275
Synonym: SCA 136
Target: 5-HT Receptor
Prednicarbate
T21443
Synonym: Hoe 777,Hoe-777,Dermatop E emollient,UNII-V901LV1K7D
Target: Others
Trans-​2-​butene-​1,​4-​dicarboxylic acid
T5246
Synonym: trans-2-Butene-1,4-dicarboxylic Acid,3-Hexenedioic Acid,trans-3-Hexenedioic Acid,β-Hydromuconic Acid
Target: Others, Endogenous Metabolite
1,3-Dicaffeoylquinic acid
T5736
Synonym: CYNARIN,Cyclohexanecarboxyli​c acid, 1,​3-​bis[[3-​(3,​4-​dihydroxyphenyl)​-​1-​oxo-​2-​propen-​1-​yl]​oxy]​-​4,​5-​dihydroxy-​, (1S,​3R,​4R,​5R)​-,1,3-O-Dicaffeoylquinic acid,1,5-Dicaffeoylquinic acid
Target: Reactive Oxygen Species, Akt, PI3K
Ticagrelor metabolite M5
T21059
Synonym: Ticagrelor metabolite M5,,T437700,AR-C133913XX
Target: P2Y Receptor
Anticancer agent 43
T61046
Synonym:
Target: Apoptosis
Di-tert-butyl dicarbonate
T77707
Synonym: BOC anhydride
Target: Others
4-Cyclohexyl-1-phenylthiosemicarbazide
T1727
Synonym:
Target: Others
Isatin-β-thiosemicarbazone
T60272
Synonym: IBT
Target: HSV
Ampiroxicam
T6387
Synonym: CP 65703,Flucam
Target: COX
Nicainoprol
T4539
Synonym: RU-42924
Target: Sodium Channel
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TargetMol