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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T15546 | ICA | N-[4-(2-Pyridinyl)-2-thiazolyl]-2-pyridinamine | Potassium Channel , Parasite |
ICA (N-[4-(2-Pyridinyl)-2-thiazolyl]-2-pyridinamine) is a SK channel inhibitor and exhibits antileishmanial activity (IC50: 2.1 µM). | |||
T9009 | ICA-105574 | ICA,3-nitro-N-[4-phenoxyphenyl]-benzamide | HER |
ICA-105574 (ICA) is an activator of hERG that binds to the channel to remove inactivation, thus increasing peak current amplitude and shortening the action potential. It also modulates activation kinetics of the channel. | |||
T15545 | ICA-27243 | Potassium Channel | |
ICA-27243 is less effective at activating KCNQ4 and KCNQ3/Q5. ICA-27243 is a potent and orally active KCNQ2/Q3 potassium channel opener (EC50: 0.38 μM). ICA-27243 also has antiepileptic and anticonvulsant effects. | |||
T7612 | ICA 110381 | Potassium Channel | |
ICA 110381 is a KCNQ2/Q3 potassium channel opener for the treatment of epilepsy | |||
T7336 | ICA-121431 | 2,2-Diphenyl-N-[4-(thiazol-2-ylsulfamoyl | Sodium Channel |
ICA-121431 (2,2-Diphenyl-N-[4-(thiazol-2-ylsulfamoyl) is a nanomolar potent small molecule Nav1.7 channel inhibitor with IC50 of 19 nM for rat Nav1.7, with little or no activity against human Nav1.5 or Nav1.7 channels. | |||
T3959 | ICA-069673 | ICA069673 | Potassium Channel |
ICA-069673 is an activator of KCNQ2/Q3 potassium channel (IC50: 0.69 μM). | |||
T3528 | Senicapoc | ICA-17043 | Potassium Channel |
Senicapoc (ICA-17043) is a potent inhibitor of the Gardos channel and ameliorates RBC dehydration in the SAD mouse. Senicapoc blocked Ca2+-induced rubidium flux from human RBCs with an IC50 value of 11 ± 2 nM (CLT IC50 =... | |||
T11606 | ICA-105665 | PF-04895162 | Others |
ICA-105665 (PF-04895162) is a potent and orally active neuronal Kv7.2/7.3 and Kv7.3/7.5 potassium channels opener. ICA-105665 had low cytotoxic potential in human hepatocytes but inhibited liver mitochondrial function an... | |||
T6456 | CRT0044876 | NSC 69877,7-NO2-ICA,NSC 69877,7-Nitroindole-2-Carboxylic Acid | DNA/RNA Synthesis |
CRT0044876 (7-NO2-ICA) is a potent and selective APE1 inhibitor with IC50 of ~3 μM. | |||
T13275 | Vabicaserin hydrochloride | SCA 136 | 5-HT Receptor |
Vabicaserin hydrochloride (SCA 136) is a selective agonist of 5-hydroxytryptamine 2C (5-HT2C) receptor (EC50: 8 nM). | |||
T21443 | Prednicarbate | Hoe 777,Hoe-777,Dermatop E emollient,UNII-V901LV1K7D | Others |
Prednicarbate (Hoe 777) is a Corticosteroid Hormone Receptor Agonist. Prednicarbate has antipruritic, anti-inflammatory, and vasoconstrictive properties. It also decreases the number of circulating lymphocytes by inhibit... | |||
T5246 | Trans-2-butene-1,4-dicarboxylic acid | trans-2-Butene-1,4-dicarboxylic Acid,3-Hexenedioic Acid,trans-3-Hexenedioic Acid,β-Hydromuconic Acid | Others , Endogenous Metabolite |
Trans-2-butene-1,4-dicarboxylic acid (3-Hexenedioic Acid) is a normal human unsaturated dicarboxylic acid metabolite with increased excretion in patients with Dicarboxylic aciduria caused by fatty acid metabolism disorde... | |||
T5736 | 1,3-Dicaffeoylquinic acid | CYNARIN,Cyclohexanecarboxylic acid, 1,3-bis[[3-(3,4-dihydroxyphenyl)-1-oxo-2-propen-1-yl]oxy]-4,5-dihydroxy-, (1S,3R,4R,5R)-,1,3-O-Dicaffeoylquinic acid,1,5-Dicaffeoylquinic acid | Reactive Oxygen Species , Akt , PI3K |
1,3-Dicaffeoylquinic acid (CYNARIN) is a natural product. It shows antioxidant and choleretic properties and is a potential immunosuppressive agent. | |||
T21059 | Ticagrelor metabolite M5 | Ticagrelor metabolite M5,,T437700,AR-C133913XX | P2Y Receptor |
Ticagrelor metabolite M5 (T437700) is a metabolite of Ticagrelor, the first reversible oral antagonist of P2Y12 receptor. Compared to Clopidogrel, Ticagrelor has faster and more consistent inhibition on ADP-receptors. Ti... | |||
T61046 | Anticancer agent 43 | Apoptosis | |
Anticancer agent 43 is a potent anticancer agent that induces apoptosis through caspase 3, PARP1, and Bax protein-dependent pathways.Anticancer agent 43 induces DNA damage and can be used in the study of glioblastoma in ... | |||
T77707 | Di-tert-butyl dicarbonate | BOC anhydride | Others |
Di-tert-butyl dicarbonate(BOC anhydride) is a biochemical reagent that can be used in biochemical experiments. | |||
T1727 | 4-Cyclohexyl-1-phenylthiosemicarbazide | Others | |
4-Cyclohexyl-1-phenylthiosemicarbazide is employed as an intermediate. | |||
T60272 | Isatin-β-thiosemicarbazone | IBT | HSV |
Isatin-β-thiosemicarbazone is a potent inhibitor of herpes simplex virus (HSV). isatin-β-thiosemicarbazone exhibits antiviral activity by inhibiting both HSV-1 and HSV-2. isatin-β-thiosemicarbazone is Isatin-β-thiosemica... | |||
T6387 | Ampiroxicam | CP 65703,Flucam | COX |
Ampiroxicam (Flucam) is a nonselective cyclooxygenase inhibitor uesd as anti-inflammatory drug. | |||
T4539 | Nicainoprol | RU-42924 | Sodium Channel |
Nicainoprol (RU-42924) is a fast-sodium-channel blocking drug. Nicainoprol is a potent antiarrhythmic agent. |