Home Tools

Cart

Nicainoprol

Catalog No. T4539 CAS 76252-06-7

Synonyms: RU-42924

Nicainoprol (RU-42924) is a fast-sodium-channel blocking drug. Nicainoprol is a potent antiarrhythmic agent.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Nicainoprol, CAS 76252-06-7

Pack Size	Availability	Price/USD
1 mg	In stock	$ 177.00
5 mg	In stock	$ 443.00
10 mg	In stock	$ 653.00
25 mg	In stock	$ 987.00
50 mg	In stock	$ 1,390.00
100 mg	In stock	$ 1,880.00
1 mL * 10 mM (in DMSO)	In stock	$ 597.00

Bulk Inquiry

Select Batch

Purity: 100%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Nicainoprol (RU-42924) is a fast-sodium-channel blocking drug. Nicainoprol is a potent antiarrhythmic agent.
In vitro	The antiarrhythmic agent Nicainoprol is a fast-sodium-channel blocking drug that also protects isolated rat hearts against reperfusion arrhythmias. However, it is without beneficial effects on cardiac hemodynamics and biochemical parameters, in contrast to the ACE inhibitor[1].
In vivo	The study investigates the efficacy of Nicainoprol, a novel antiarrhythmic agent, in mitigating coronary occlusion and reperfusion arrhythmias in both isolated working rat hearts and anesthetized rats. In isolated hearts, Nicainoprol demonstrates a concentration-dependent protective effect against reperfusion arrhythmia without altering cardiodynamics, except for a decrease in heart rate at the highest tested concentration (100 μM). Key cardiac biochemical markers (lactate dehydrogenase and creatine kinase) and metabolite levels (glycogen, lactate, ATP, and creatine phosphate) remain unchanged by Nicainoprol treatment. In anesthetized rats, Nicainoprol administration (5 and 10 mg/kg, i.v.) significantly diminishes the incidence of premature ventricular complexes and ventricular tachycardia during the early post-occlusion phase (0-30 minutes), and entirely prevents ventricular fibrillation. During reperfusion, Nicainoprol-treated rats show a marked reduction in premature ventricular complexes compared to control rats, alongside reductions in heart rate, blood pressure, and myocardial oxygen consumption. Furthermore, Nicainoprol significantly decreases the ratio of infarct mass to ventricular mass by 20% and 28% at doses of 5 mg/kg and 10 mg/kg, respectively, indicating potential benefits in preventing and treating arrhythmias associated with acute myocardial infarction.

Synonyms	RU-42924
Molecular Weight	369.46
Formula	C21H27N3O3
CAS No.	76252-06-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 55 mg/mL (148.87 mM)

References and Literature

1. Linz W, et al. Cardiac arrhythmias are ameliorated by local inhibition of angiotensin formation and bradykinin degradation with the converting-enzyme inhibitor ramipril. Cardiovasc Drugs Ther. 1989 Dec;3(6):873-82. 2. Martorana PA, et al. Effects of nicainoprol on reperfusion arrhythmia in the isolated working rat heart and on ischemia and reperfusion arrhythmia and myocardial infarct size in the anesthetized rat. Eur J Pharmacol. 1987 Nov 17;143(3):391-401.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Bioactive Compound Library NO PAINS Compound Library Anti-Cardiovascular Disease Compound Library Bioactive Compounds Library Max Ion Channel Inhibitor Library Sodium Channel Blocker Library ReFRAME Related Library Target-Focused Phenotypic Screening Library Anti-Cancer Compound Library

Related Products

Related compounds with same targets

µ-Conotoxin BuIIIC Amitriptyline hydrochloride Phlo1b Dimethyl lithospermate B Bulleyaconitine A Disopyramide DPI 201-106 mHuwentoxin-IV

Dose Conversion

You can also refer to dose conversion for different animals. More

In vivo Formulation Calculator (Clear solution)

Step One: Enter information below

Dosage

mg/kg

Average weight of animals

Dosing volume per animal

Number of animals

Step Two: Enter the in vivo formulation

% DMSO+

% +

% Tween 80+

% ddH₂O

%DMSO+

Calculate Reset

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

Calculator

Molarity Calculator

Dilution Calculator

Reconstitution Calculation

Molecular Weight Calculator

Mass

Concentration

Volume

Molecular Weight

Molarity Calculator allows you to calculate the

Mass of a compound required to prepare a solution of known volume and concentration
Volume of solution required to dissolve a compound of known mass to a desired concentration
Concentration of a solution resulting from a known mass of compound in a specific volume

See Example

An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
Enter 197.13 into the Molecular Weight (MW) box
Enter 10 into the Concentration box and select the correct unit (millimolar)
Enter 10 into the Volume box and select the correct unit (milliliter)
Press calculate
The answer of 19.713 mg appears in the Mass box

Concentration (Start)

Volume (Start)

Concentration (End)

Volume (End)

Calculator the dilution required to prepare a stock solution

Calculate the dilution required to prepare a stock solution
The dilution calculator is a useful tool which allows you to calculate how to dilute a stock solution of known concentration. Enter C1, C2 & V2 to calculate V1.

See Example

An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
Enter 10 into the Concentration (start) box and select the correct unit (millimolar)
Enter 50 into the Concentration (final) box and select the correct unit (micromolar)
Enter 20 into the Volume (final) box and select the correct unit (milliliter)
Press calculate
The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

Calculate the volume of solvent required to reconstitute your vial.

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial.
Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Molecule Formula

Molecular Weight g/mol

Enter the chemical formula of a compound to calculate its molar mass and elemental composition

Tip: Chemical formula is case sensitive: C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:
To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.
Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

bottom

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Nicainoprol 76252-06-7 Membrane transporter/Ion channel Sodium Channel Na+ channels inhibit Inhibitor Na channels RU 42924 RU-42924 RU42924 inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.