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ICA-069673

Catalog No. T3959 CAS 582323-16-8

Synonyms: ICA069673

ICA-069673 is an activator of KCNQ2/Q3 potassium channel (IC50: 0.69 μM).

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ICA-069673, CAS 582323-16-8

Pack Size	Availability	Price/USD
2 mg	In stock	$ 41.00
5 mg	In stock	$ 67.00
10 mg	In stock	$ 117.00
25 mg	In stock	$ 257.00
50 mg	In stock	$ 457.00
100 mg	In stock	$ 679.00
500 mg	In stock	$ 1,430.00
1 mL * 10 mM (in DMSO)	In stock	$ 74.00

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Purity: 99.66%

Purity: 98.97%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	ICA-069673 is an activator of KCNQ2/Q3 potassium channel (IC50: 0.69 μM).
Targets&IC50	KCNQ2/Q3:0.69 μM
In vitro	ICA-069673 is 20-fold selective for KCNQ2/Q3 over KCNQ3/Q5. It has no inhibitory against a panel of cardiac ion channels (IC50> 30 μM for hERG, Nav1.5, L type channels, and KCNQ1). ICA-069673 (10 μM) has no activity on GABA(A) gated channels. ICA-069673 exhibits much stronger effects on KCNQ2 channels, including a large hyperpolarizing shift of the voltage-dependence of activation, a 2-fold enhancement of peak current and pronounced subtype specificity for KCNQ2 over KCNQ3.

Synonyms	ICA069673
Molecular Weight	269.63
Formula	C11H6ClF2N3O
CAS No.	582323-16-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (185.43 mM)

References and Literature

1. Wickenden AD, et al. N-(6-chloro-pyridin-3-yl)-3,4-difluoro-benzamide (ICA-27243): a novel, selective KCNQ2/Q3 potassium channel activator. Mol Pharmacol. 2008 Mar;73(3):977-86. Epub 2007 Dec 18. 2. Wang AW, et al. Sequence determinants of subtype-specific actions of KCNQ channel openers. J Physiol. 2017 Feb 1;595(3):663-676.

Related compound libraries

This product is contained In the following compound libraries：

Bioactive Compounds Library Max Anti-Cancer Compound Library Fluorochemical Library Ion Channel Inhibitor Library Bioactive Compound Library Potassium Channel Blocker Library ReFRAME Related Library NO PAINS Compound Library Covalent Inhibitor Library

Related Products

Related compounds with same targets

SKF-96365 hydrochloride Cesium chloride KCNQ1 activator-1 NS3623 Spinoxin Branaplam VU590 Chlorzoxazone

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Keywords

ICA-069673 582323-16-8 Membrane transporter/Ion channel Potassium Channel KcsA ICA 069673 ICA069673 inhibit Inhibitor inhibitor

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