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Membrane transporter/Ion channel Potassium Channel ICA-27243

ICA-27243

Catalog No. T15545   CAS 325457-89-4

ICA-27243 is less effective at activating KCNQ4 and KCNQ3/Q5. ICA-27243 is a potent and orally active KCNQ2/Q3 potassium channel opener (EC50: 0.38 μM). ICA-27243 also has antiepileptic and anticonvulsant effects.

ICA-27243, CAS 325457-89-4
Pack Size Availability Price/USD Quantity
5 mg In stock 92.00
10 mg In stock 151.00
50 mg In stock 493.00
100 mg In stock 834.00
200 mg In stock inquiry
500 mg In stock inquiry
1 mL * 10 mM (in DMSO) In stock 101.00
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Purity 99.79%
Biological Description
Chemical Properties
Storage & Solubility Information
Description ICA-27243 is less effective at activating KCNQ4 and KCNQ3/Q5. ICA-27243 is a potent and orally active KCNQ2/Q3 potassium channel opener (EC50: 0.38 μM). ICA-27243 also has antiepileptic and anticonvulsant effects.
Targets&IC50 KCNQ2/Q3 potassium channel : (EC50)0.38 μM
In vivo In the mouse maximal electroshock epilepsy model, ICA-27243 (1-100 mg/kg; oral administration; male CD-1 mice) has anticonvulsant activity (ED50: 8.4 mg/kg)[1].
Molecular Weight 268.65
Formula C12H7ClF2N2O
CAS No. 325457-89-4

Storage

0-4℃ for short term (days to weeks), or -20℃ for long term (months).

Solubility Information

DMSO: 247 mg/mL (919.41mM), Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Wickenden AD, et al. N-(6-chloro-pyridin-3-yl)-3,4-difluoro-benzamide (ICA-27243): a novel, selective KCNQ2/Q3 potassium channel activator. Mol Pharmacol. 2008 Mar;73(3):977-86. 2. Amato G, et al. N-Pyridyl and Pyrimidine Benzamides as KCNQ2/Q3 Potassium Channel Openers for the Treatment of Epilepsy. ACS Med Chem Lett. 2011 Mar 31;2(6):481-4.

Related Products

Related compounds with same targets
ICA-27243 Pinacidil monohydrate Doxapram hydrochloride monohydrate Retigabine dihydrochloride Paederosidic acid methyl ester Oleandrin Oxypeucedanin DPO-1

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