hippocampus — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T23513	VU10010	VU 10010	AChR
	VU10010 (VU 10010) is allosteric potentiator of M4 acetylcholine receptors.		AChR
T8702	SKF-83566		Dopamine Receptor , 5-HT Receptor , AChR
	SKF-83566 is a blood-brain permeable and orally active antagonist of D1-like dopamine receptor and a weaker competitive 5-HT2 receptor antagonist with Ki of 11 nM		Dopamine Receptor , 5-HT Receptor , AChR
T1566	Aripiprazole	OPC-14597	5-HT Receptor
	Aripiprazole (OPC-14597) is an antipsychotic agent that is structurally related to piperazines and quinolones. It is a partial agonist of SEROTONIN RECEPTOR, 5-HT1A and DOPAMINE D2 RECEPTORS, where it also functions as a...		5-HT Receptor
T19333	Gadoteridol	ProHance,SQ-32692,Gd-HP-DO3A	Others
	Gadoteridol (Gd-HP-DO3A) is a gadolinium-based MRI contrast agent that can be used for central nervous system imaging.		Others
T4297	Flibanserin	BIMT-17BS,Girosa,BIMT-17	Dopamine Receptor , 5-HT Receptor
	Flibanserin (Girosa) is a serotonergic antidepressant used to treat hypoactive sexual desire disorder. Flibanserin has been associated with a low rate of minor serum aminotransferase elevations during treatment but has n...		Dopamine Receptor , 5-HT Receptor
T12617L	(R)-CR8	(R)-CR8,(R)-Isomer,CR8	Apoptosis , CDK
	(R)-CR8 ((R)-Isomer) is a potent and selective CDK inhibitor.		Apoptosis , CDK
T16816	S 18986		GluR
	S 18986 is a selective, orally active, brain penetrant positive allosteric modulator of AMPA-type receptors, showcasing cognitive-enhancing properties in rodents. It induces the release of noradrenaline and acetylcholine...		GluR
T61934	Repinotan
	Repinotan (BAY x 3702 free base) is an effective, selective, blood-brain barrier permeable, oral active 5-HT1A receptor agonist. The Ki values of Repinotan are 0.19 nM (calf hippocampus), 0.25 nM (rat and human cortex) a...
T5468	YF-2		Others , Epigenetic Reader Domain , Histone Acetyltransferase
	YF-2 is blood-brain-barrier permeable histone acetyltransferase activator, acetylates H3 in the hippocampus, CBP, PCAF, and GCN5 with EC50s of 2.75 μM, 29.04 μM and 49.31 μM , respectively
T3767	Polygalacic acid	Virgaureagenin G	MMP , AChR , AChE
	Polygalacic acid (Virgaureagenin G)(PA) significantly improves cholinergic system reactivity, as indicated by decreased acetylcholinesterase (AChE) activity, increases choline acetyltransferase (ChAT) activity, and eleva...		MMP , AChR , AChE
T6S2227	Spinosin	Flavoayamenin	Others
	1. Spinosin (Flavoayamenin) ameliorated memory impairment induced through AβO, the serotonergic neurotransmitter system, and these effects were regulated, in part, through neuroprotective activity via the anti-inflammato...		Others
T11800	L-803087		Somatostatin
	L-803087 is a potent and selective agonist of the growth inhibitor sst4 receptor with a Ki value of 0.7 nM for sst4, which is more than 280-fold more selective than other growth inhibitory receptors.L-803087 induced AMPA...		Somatostatin
T4956	Tetrahydroxystilbene-2-O-β-D-glucoside	tetrahydroxyl diphenylethylene-2-o-gluco,EH-201	Others
	Tetrahydroxystilbene-2-O-β-D-glucoside (EH-201) is a low MW inducer of erythropoietin. Tetrahydroxystilbene-2-O-β-D-glucoside induces expression of erythropoietin, PPAR-γ coactivator 1α (PGC-1α) and haemoglobin in astroc...		Others
T3779	Crocin II	Crocin 2,Crocetin gentiobiosylglucosyl ester,Tricrocin,Crocin B	Caspase , COX , NO Synthase
	Crocin II (Crocetin gentiobiosylglucosyl ester) has anti-inflammatory and anti-apoptotic effects against gastric ischemia-reperfusion injury in rats, the effect of crocin is mainly mediated by reducing the protein expres...		Caspase , COX , NO Synthase
T37190	L-Allylglycine		Dehydrogenase , GABA Receptor
	L-Allylglycine is an amino acid derivative that reduces glutamate decarboxylase (GAD) activity by 60% when administered at a dose of 39.8 μmol/g per hour ex vivo in mouse brain preparations. L-Allylglycine (1.2 mmol/kg, ...		Dehydrogenase , GABA Receptor
T13975	ZSET-845		Others
	ZSET-845 is an enhancer of cognitive which enhances choline acetyltransferase activity in the hippocampus in the rat.		Others
T28139	NCFP
	NCFP is a mGlu5 positive allosteric modulator. It positively modulates mGlu5 without the induction of long-term potentiation and long-term depression in the hippocampus.
T10542	Bifeprunox		Others
	Bifeprunox is a potent partial agonist of dopamine D2-like and 5-HT1A receptor (pEC50: 6.37 for hippocampus 5-HT1A; pKis: 7.19 and 8.83 for cortex 5-HT1A and striatum D2). It is an antipsychotic for the research of schiz...		Others
T38217	1-Stearoyl-2-Adrenoyl-sn-glycero-3-PE
	1-Stearoyl-2-adrenoyl-sn-glycero-3-PE is a phospholipid that contains stearic acid and adrenic acid at thesn-1 andsn-2 positions, respectively. 1-Stearoyl-2-adrenoyl-sn-glycero-3-PE levels are inversely correlated with s...
TP1188	Cortistatin 14, human, rat	CST-14, human, rat
	Cortistatin 14 is a somatastatin-like neuropeptide with neuronal depressant and sleep modulating properties. Cortistatin 14 is present primarily in the cortex and hippocampus.