Powder: -20°C for 3 years | In solvent: -80°C for 1 year
S 18986 is a selective, orally active, brain penetrant positive allosteric modulator of AMPA-type receptors, showcasing cognitive-enhancing properties in rodents. It induces the release of noradrenaline and acetylcholine in the rat hippocampus, leading to enhanced object-recognition memory.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 44.00 | |
5 mg | In stock | $ 97.00 | |
10 mg | In stock | $ 172.00 | |
25 mg | In stock | $ 361.00 | |
50 mg | In stock | Inquiry |
Description | S 18986 is a selective, orally active, brain penetrant positive allosteric modulator of AMPA-type receptors, showcasing cognitive-enhancing properties in rodents. It induces the release of noradrenaline and acetylcholine in the rat hippocampus, leading to enhanced object-recognition memory. |
In vivo | S 18986 displays antiamnesic properties in middle-aged rodents in spatial memory models. S 18986 is robust memory-enhancing effects in middle-aged animals compared with aged ones. S 18986 (5-50 mg/kg; i.p.) obviously enhances both the induction and the maintenance of 4 and 20 bursts tetanus-evoked potentiation [1]. |
Molecular Weight | 224.28 |
Formula | C10H12N2O2S |
CAS No. | 175340-20-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 20 mg/ml(89.17 mM)
You can also refer to dose conversion for different animals. More
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S 18986 175340-20-2 Neuroscience GluR S18986 S-18986 inhibitor inhibit