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Search Results for " dr5 "

Targets

Compounds

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T2065	Bioymifi	DR5 Activator	Apoptosis , TNF
	Bioymifi (DR5 Activator) is a novel and potent small-molecule activator of the TRAIL receptor DR5 in human cancer cells.		Apoptosis , TNF
T76815	Lexatumumab	ETR2-ST01,DR5 mAB,HGS-ETR 2	Apoptosis
	Lexatumumab (GHS-ETR 2) is a human excitatory monoclonal antibody targeting TRAIL receptor 2 that has anticancer activity and induces apoptosis in malignant mesothelioma. Lexatumumab can be used to study malignant pleura...		Apoptosis
T80984	Tilogotamab	GEN-1029,HexaBody-DR5/DR5,Hx-DR5-01/05
	Tilogotamab (GEN-1029) is an enhanced hexameric mixture of two agonistic antibodies that bind to distinct epitopes on death receptor type 5 (DR5), specifically activating it. This compound is utilized in the research of ...
T1167	Cyproterone acetate	Androcur,Cyproterone 17-O-acetate	Androgen Receptor
	Cyproterone acetate (Cyproterone 17-O-acetate) binds the androgen receptor (AR), thereby preventing androgen-induced receptor activation in target tissues and inhibiting the growth of testosterone-sensitive tumor cells. ...		Androgen Receptor
T3201	WDR5-0103	WD-Repeat Protein 5-0103	Histone Methyltransferase , JAK
	WDR5-0103 (WD-Repeat Protein 5-0103) is an effective and specific WD repeat-containing protein 5 (WDR5) antagonist (Kd: 450 nM).		Histone Methyltransferase , JAK
T5140	WDR5-0103 hydrochloride[890190-22-4(free base)]	WD-Repeat Protein 5-0103	JAK
	WDR5-0103 hydrochloride[890190-22-4(free base)] (WD-Repeat Protein 5-0103) is an effective and specific WD repeat-containing protein 5 (WDR5) antagonist (Kd: 450 nM).		JAK
T67697	WDR5-47		Histone Methyltransferase
	WDR5-47 is a potent small molecule to disturb the interaction of MLL1-WDR5 with IC50 value of 0.3μM.		Histone Methyltransferase
T67947	WDR5-0102		Histone Methyltransferase
	WDR5-0102 is a compound that inhibits the WDR5-MLL1 interface (K dis = 7 μM, K d = 4 μM), selectively reducing MLL1 HMT activity without affecting the human H3K4 methyltransferase SETD7 or other HMTs, including G9a, EHMT...		Histone Methyltransferase
T77495	WDR5-IN-6		JAK
	WDR5-IN-6 is a WDR5 inhibitor targeting the WBM locus.WDR5-IN-6 is highly synergistic with OICR-9429, a WDR5 inhibitor that targets the WIN locus.WDR5-IN-6 exhibits potent antitumor activity and inhibits cell proliferati...		JAK
T63763	WDR5-IN-5
	WDR5-IN-5 is a selective, orally active inhibitor targeting the WD repeat domain 5 (WDR5) WIN site.WDR5-IN-5 exhibits high affinity for WDR5 (Ki<0.02 nM).WDR5-IN-5 exhibits anti-cancer cell proliferation and a good pharm...
T73724	WDR5-IN-4 TFA
	WDR5-IN-4 TFA is an inhibitor of the WIN site of chromatin-associated WD repeat-containing protein 5 ( WDR5 ), with a K d of 0.1 nM. WDR5-IN-4 TFA displaces WDR5 from chromatin and decreases the expression of associated ...
T13334	WDR5-IN-1		Others
	WDR5-IN-1 is a potent and selective inhibitor of WD repeat domain 5 (WDR5) (Kd <0.02 nM), and also inhibits MLL1 histone methyltransferase (HMT) activity (IC50: 2.2 nM).		Others
T74734	Truncated ADR58
	Truncated ADR58, derived by shortening full-length ADR58 from 71 bases to 31 bases, maintains comparable functional activity to its full-length counterpart. This compound acts as a potent and selective antagonist of huma...
T13342	WDR5-IN-4	WIN site inhibitor 1	Others
	WIN site inhibitor 1 is a WIN site of chromatin-associated WD repeat-containing protein 5 (WDR5) inhibitor (Kd: 0.1 nM), with anti-cancer activity.		Others
T76787	Conatumumab	TRAIL-R2 mAb,AMG 655	TNF
	Conatumumab (AMG 655) is a monoclonal agonist antibody targeting human death receptor 5 (DR5, TRAILR2) at Kd 1 nM for long DR5 and Kd 0.8 nM for short DR5. Conatumumab induces apoptosis in a variety of tumor types throug...		TNF
T41068	P53R3		p53
	P53R3 is a potent reactivator of p53, effectively restoring sequence-specific DNA binding to several p53 hot spot mutants, namely p53 R175H, p53 R248W, and p53 R273H. This compound exhibits p53-dependent antiproliferativ...		p53
T26709	Azadirone
	Azadirone is a limonoid tetranortriterpene. Azadirone can sensitize cancer cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) through ROS-ERK-CHOP-mediated up-regulation of DR4 and DR5 signaling, do...
T76925	Benufutamab
	Benufutamab (GEN1029), a death receptor 5 (DR5)-specific agonistic antibody, comprises a blend of two non-competing DR5-specific IgG1 antibodies with an E430G mutation in the Fc domain. This compound exhibits antitumor e...
T76793	Tigatuzumab
	Tigatuzumab (CS-1008), a humanized IgG1 monoclonal antibody, specifically targets death receptor 5 (DR5), inducing apoptosis in cancer cells and inhibiting tumor growth in vivo. It holds potential for cancer research app...
T76802	Drozitumab
	Drozitumab (PRO 95780) is an agonistic human monoclonal antibody targeting the death receptor DR5. It demonstrates significant antitumor efficacy against rhabdomyosarcoma [1] [2] [3].
T71230	VMY-1-103
	VMY-1-103 is a potent CDK inhibitor, is also a novel dansylated analog of purvalanol B, was shown to inhibit cell cycle progression and proliferation in prostate and breast cancer cells more effectively than purvalanol B...
T35558	KAAD-Cyclopamine
	Cyclopamine-KAAD is a potent inhibitor of hedgehog signaling with an IC50 value of 20 nM in a Shh-LIGHT2 assay. It blocks binding of BODIPY-cyclopamine to cells expressing Smoothened (Smo) in a dose-dependent manner. Cyc...

Compounds

Bioymifi

T2065

Synonym: DR5 Activator

Target: Apoptosis, TNF

Lexatumumab

T76815

Synonym: ETR2-ST01,DR5 mAB,HGS-ETR 2

Target: Apoptosis

Tilogotamab

T80984

Synonym: GEN-1029,HexaBody-DR5/DR5,Hx-DR5-01/05

Target:

Cyproterone acetate

T1167

Synonym: Androcur,Cyproterone 17-O-acetate

Target: Androgen Receptor

WDR5-0103

T3201

Synonym: WD-Repeat Protein 5-0103

Target: Histone Methyltransferase, JAK

WDR5-0103 hydrochloride[890190-22-4(free base)]

T5140

Synonym: WD-Repeat Protein 5-0103

Target: Histone Methyltransferase

WDR5-0102

T67947

Synonym:

Target: Histone Methyltransferase

Synonym: WIN site inhibitor 1

Target: Others

Conatumumab

T76787

Synonym: TRAIL-R2 mAb,AMG 655

Cat No.	Product Name	Synonyms	Targets
T1678	Nystatin	Stamycin,Fungicidin,Nystavescent	Apoptosis , Antibiotic , Antifungal
	Nystatin (Fungicidin) is a topical and oral antifungal agent with activity against many species of yeast and candida albicans, which is used largely to treat skin and oropharyngeal candidiasis.		Apoptosis , Antibiotic , Antifungal

Natural Products

Nystatin

T1678

Synonym: Stamycin,Fungicidin,Nystavescent

Target: Apoptosis, Antibiotic, Antifungal

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-01185	DR5/TRAIL R2 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	DR5/TRAIL R2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 15.7 kDa and the accession number is O14763-1.
TMPY-05388	DR5/TRAIL R2 Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	DR5/TRAIL R2 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 41 kDa and the accession number is AAB67103.1.
TMPJ-00246	TRAIL R2/DR5/TNFRSF10B Protein, Mouse, Recombinant (hFc)	Mouse	HEK293 Cells
	TRAIL R2/DR5/TNFRSF10B Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 50-75 KDa and the accession number is Q9QZM4.
TMPY-05477	DR5/TRAIL R2 Protein, Human, Recombinant (His), Biotinylated	Human	HEK293 Cells
	DR5/TRAIL R2 Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 15.8 kDa and the accession number is O14763-1.
TMPK-00276	TRAIL R2/DR5/TNFRSF10B Protein, Human, Recombinant (His & Avi)	Human	HEK293 Cells
	DR5, also called TRAIL R2, TRICK 2, TNFRSF10B, and MK is a type 1 TNF R superfamily, membrane protein which is a receptor for TRAIL (APO2 ligand). DR5 is a receptor for the cytotoxic ligand TNFSF10/TRAIL. The resulting d...
TMPY-01452	DR5/TRAIL R2 Protein, Mouse, Recombinant (His & hFc)	Mouse	HEK293 Cells
	DR5/TRAIL R2 Protein, Mouse, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 41.8 kDa and the accession number is Q9QZM4.
TMPK-00277	TRAIL R2/DR5/TNFRSF10B Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	DR5, also called TRAIL R2, TRICK 2, TNFRSF10B, and MK is a type 1 TNF R superfamily, membrane protein which is a receptor for TRAIL (APO2 ligand). DR5 is a receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter mol...
TMPY-01437	DR5/TRAIL R2 Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	DR5/TRAIL R2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 15 kDa and the accession number is Q9QZM4.
TMPY-06835	DR5/TRAIL R2 Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293 Cells
	DR5/TRAIL R2 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 17.54 kDa and the accession number is NP_003833.4.
TMPJ-00245	TRAIL R2/DR5/TNFRSF10B Protein, Mouse, Recombinant (Avi & His), Biotinylated	Mouse	HEK293 Cells
	TRAIL R2/DR5/TNFRSF10B Protein, Mouse, Recombinant (Avi & His), Biotinylated is expressed in HEK293 mammalian cells with C-Avi-6xHis tag. The predicted molecular weight is 20-40 KDa and the accession number is Q9QZM4.
TMPJ-00276	TRAIL R2/DR5/TNFRSF10B Protein, Human, Recombinant (hFc & His)	Human	HEK293 Cells
	TRAIL R2/DR5/TNFRSF10B Protein, Human, Recombinant (hFc & His) is expressed in HEK293 mammalian cells with C-Fc-6xHis tag. The predicted molecular weight is 49 KDa and the accession number is O14763.
TMPJ-00430	TRAIL R2/DR5/TNFRSF10B Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293 Cells
	TRAIL R2/DR5/TNFRSF10B Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 22-30 KDa and the accession number is A0A2K5TXK0.
TMPJ-00275	TRAIL R2/DR5/TNFRSF10B Protein, Human, Recombinant (Avi & His), Biotinylated	Human	HEK293 Cells
	TRAIL R2/DR5/TNFRSF10B Protein, Human, Recombinant (Avi & His), Biotinylated is expressed in HEK293 mammalian cells with C-Avi-6xHis tag. The predicted molecular weight is 18-25 KDa and the accession number is O14763.
TMPH-02311	WDR5 Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	WDR5 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 52.5 kDa and the accession number is P61964.
TMPK-00171	TRAIL Trimer Protein, Human, Recombinant (His & Flag)	Human	HEK293 Cells
	Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a member of the TNF superfamily that can initiate the apoptosis pathway by binding to its associated death receptors DR4 and DR5. The activation of...
TMPK-00708	TRAIL R1/DR4/TNFRSF10A Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) induces apoptosis selectively via its interaction with the death receptors TRAILR1/DR4 and TRAILR2/DR5 in a wide range of cancers, while sparing norma...
TMPK-00248	TRAIL R4/TNFRSF10D Protein, Human, Recombinant (His & Avi)	Human	HEK293 Cells
	TNF-related apoptosis inducing ligand (TRAIL) is a potential antitumor protein known for its ability to selectively eliminate various types of tumor cells without exerting toxic effects in normal cells and tissues. TRAIL...
TMPK-00249	TRAIL R4/TNFRSF10D Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293 Cells
	TNF-related apoptosis inducing ligand (TRAIL) is a potential antitumor protein known for its ability to selectively eliminate various types of tumor cells without exerting toxic effects in normal cells and tissues. TRAIL...