Powder: -20°C for 3 years | In solvent: -80°C for 1 year
WDR5-IN-1 is a potent and selective inhibitor of WD repeat domain 5 (WDR5) (Kd <0.02 nM), and also inhibits MLL1 histone methyltransferase (HMT) activity (IC50: 2.2 nM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 10-14 weeks | $ 1,780.00 | |
50 mg | 10-14 weeks | $ 2,320.00 | |
100 mg | 10-14 weeks | $ 3,730.00 |
Description | WDR5-IN-1 is a potent and selective inhibitor of WD repeat domain 5 (WDR5) (Kd <0.02 nM), and also inhibits MLL1 histone methyltransferase (HMT) activity (IC50: 2.2 nM). |
In vitro | In G2M phase cells, WDR5-IN-1 (1 μM; 48 hours) shows an apparent decrease . WDR5-IN-1 (0.01-3 μM; 24-48 hours) increases p53 and p21 protein levels. WDR5-IN-1 shows anti-proliferative activity in MYC-driven cancers (CHP-134, Ramos, Raji, Daudi, SW620, SW480 cells)(GI50s : 0.26-3.2 μM). |
Molecular Weight | 514.59 |
Formula | C30H31FN4O3 |
CAS No. | 2408842-51-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
WDR5-IN-1 2408842-51-1 Others WDR-5-IN-1 WDR5 IN 1 WDR5IN1 inhibitor inhibit