chymotrypsin — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T73594	Chymotrypsin	Chymotrypsin A	Serine/threonin kinase
	Chymotrypsin (Chymotrypsin A) is a serine protease produced by the pancreas that cleaves protein chains on the carboxyl side of aromatic amino acids.		Serine/threonin kinase
T17011	TCH-165		Proteasome
	TCH-165 is a small molecule modulator of proteasome assembly, resulting in an increase in 20S levels. The increase in the level of free 20S corresponds to enhanced proteolysis of IDPs.		Proteasome
T6027	Delanzomib	CEP-18770	Apoptosis , NF-κB , Proteasome
	Delanzomib (CEP-18770) is an orally active inhibitor of the chymotrypsin-like activity of proteasome (IC50: 3.8 nM). It only marginally inhibits the tryptic and peptidylglutamyl activities of the proteosome.		Apoptosis , NF-κB , Proteasome
T21854	Proteasome inhibitor IX	PS-IX,AM114	Proteasome
	Proteasome inhibitor IX (PS-IX) is an inhibitor of chymotrypsin-like activity of the 20S proteasome (IC50 ~1 μM). Proteasome inhibitor IX shows potent anticancer activity. Proteasome inhibitor IX exhibits HCT116 p53+/+ c...		Proteasome
T76157	Chymotrypsinogen
	Chymotrypsinogen is an inactive precursor of Chymotrypsin . Chymotrypsin is a serine protease produced by the pancreas [1] [2] .
T6941	PI-1840	PI 1840	PARP , Proteasome
	PI-1840（IC50 = 27 nM）is a reversible and selective chymotrypsin-like (CT-L) inhibitor, with little proteasome proteolytic effects on trypsin-like (T-L) and postglutamyl-peptide-hydrolysis-like (PGPH-L).		PARP , Proteasome
T23233L	RETF-4NA acetate	RETF-4NA acetate（1160928-63-1 free base）	Others
	RETF-4NA acetate is a sensitive, specific substrate for chymotrypsin.		Others
T3359	Aprotinin	Bovine Pancreatic Trypsin Inhibitor,Traskolan,Antilysin	Others , Serine Protease , Influenza Virus , Proteasome
	Aprotinin (Traskolan) a broad-spectrum serine protease inhibitor, inhibiting the activity of a number of different esterases and proteases, including trypsin, chymotrypsin, kallikrein, plasmin, tissue plasminogen activat...		Others , Serine Protease , Influenza Virus , Proteasome
T7016	VR23		Apoptosis , Proteasome , Caspase
	VR23 is a potent proteasome inhibitor. Data shows IC50 =1 nM for trypsin-like proteasomes, IC50=50-100 nM for chymotrypsin-like proteasomes, and IC50=3 μM for caspase-like proteasomes.		Apoptosis , Proteasome , Caspase
TN1372	Alpha-Amyrin	alpha-Amyrenol,α-Amyrin,alpha-Amyrine,Viminalol	P450 , Serine Protease , ROS
	Alpha-Amyrin (alpha-Amyrine) is an inhibitor of trypsin and chymotrypsin with antineoplastic effects. alpha-Amyrin can be used in studies about acting as a hepatomodulatory.		P450 , Serine Protease , ROS
T6370	AEBSF hydrochloride	AEBSF HCl,Pefabloc SC	Thrombin , Serine Protease , Influenza Virus
	AEBSF hydrochloride (Pefabloc SC) is an irreversible inhibitor of serine proteases, such as chymotrypsin, kallikrein, thrombin, plasmin, and trypsin.		Thrombin , Serine Protease , Influenza Virus
T2016	MLN9708	Ixazomib Citrate	Proteasome
	MLN2238 suppresses the chymotrypsin-like proteolytic (β5) site of the 20S proteasome(Ki50=0.93 nM, IC50=3.4 nM/). The biologically active form of MLN9708 (Ixazomib Citrate) is MLN2238 in aqueous solutions or plasma.		Proteasome
T8350	TPCK		Proteasome
	TPCK is an irreversible inhibitor of chymotrypsin-like proteases that affect cell proliferation, apoptosis, and tumorigenesis		Proteasome
T1795	Carfilzomib	PR-171	Apoptosis , Proteasome , Autophagy
	Carfilzomib (PR-171) is a proteasome inhibitor that irreversibly binds to the chymotrypsin of the 20S proteasome. Carfilzomib has antitumor activity and may be used to treat multiple myeloma.		Apoptosis , Proteasome , Autophagy
T63321	20S Proteasome activator 1		Proteasome
	20S Proteasome activator 1 is a 20S proteasome activator with IC50 of 0.3 μM for trypsin-like sites, 0.7 μM for chymotrypsin-like sites and 1.8 μM for caspase sites. 20S Proteasome activator 1 prevents the accumulation o...		Proteasome
T0372	Gabexate mesylate	FOY	Factor Xa , Serine Protease , Proteasome
	Gabexate mesylate (FOY) is a serine proteinase inhibitor used therapeutically in the treatment of pancreatitis, disseminated intravascular coagulation (DIC), and as a regional anticoagulant for hemodialysis. The drug inh...		Factor Xa , Serine Protease , Proteasome
T2O2730	L-Serine	(S)-Serine,serine,(-)-Serine,(S)-2-Amino-3-hydroxypropanoic acid	Endogenous Metabolite
	L-Serine (serine) is a non-essential amino acid in humans, L-Serine is present and functionally important in many proteins.L-Serine is also found at the active site of the serine protease enzyme class that includes tryps...		Endogenous Metabolite
T2122	Ixazomib	MLN2238	Proteasome , Caspase , Autophagy
	Ixazomib (MLN2238) , a second generation, boron-containing peptide proteasome inhibitor (PI), inhibits the chymotrypsin-like proteolytic (β5) site of the 20S proteasome (IC50/Ki: 3.4/0.93 nM, in cell-free assays), also i...		Proteasome , Caspase , Autophagy
TP1832	Gluten Exorphin C		Opioid Receptor
	Gluten exorphin C is an opioid peptide derived from wheat gluten. Its IC50 values are 40 μM and 13.5 μM for μ opioid and δ opioid activities in the GPI and MVD assays, respectively.Gluten Exorphin C, isolated from the pe...		Opioid Receptor
T21617	MG-115	Z-LL-Nva-CHO	Proteasome
	MG-115 (Z-LL-Nva-CHO) is a potent and reversible inhibitor of proteasome , with K i s of 21 nM and 35 nM for 20S and 26S proteasome, respectively. MG-115 specifically inhibit the chymotrypsin-like activity of the proteas...		Proteasome