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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T0778 | Phenacetin | Acetophenetidin | COX |
Phenacetin (Acetophenetidin) is a phenylacetamide that was formerly used in ANALGESICS but nephropathy and METHEMOGLOBINEMIA led to its withdrawal from the market. | |||
T9042 | Teriflunomide impurity 3 | 4-Amino-N-(4-trifluoromethylphenyl)benzamide | COX |
Teriflunomide impurity 3 (4-Amino-N-(4-trifluoromethylphenyl)benzamide) is a selective COX-1 inhibitor(IC50 of 30 μM). It is less active against COX-2 (IC50>100 μM). | |||
T22398 | Phenidone | 1-phenyl-3-pyrazolidinone | Lipoxygenase , COX |
Phenidone (1-phenyl-3-pyrazolidinone) is a dual inhibitor of cyclooxygenases and lipoxygenases that ameliorates rat paralysis in experimental autoimmune encephalomyelitis by suppressing its target enzymes[1]. The lipoxyg... | |||
T3682 | (-)-Catechin gallate | (-)-Catechin 3-O-gallate,(-)-Catechin 3-gallate | Others , COX |
(-)-Catechin gallate ((-)-Catechin 3-O-gallate) displays inhibition of 6PGD, IDH. (-)-Catechin gallate ((-)-Catechin 3-O-gallate) displays inhibition of human Beta-secretase. (-)-Catechin gallate ((-)-Catechin 3-O-gallat... | |||
T23333 | SC-58125 | SC 58125 | COX |
SC-58125 is a selective cyclooxygenase 2 (COX-2) inhibitor, with an IC50 of 0.04 μM. SC-58125 exhibits antitumor activity in vitro and in vivo, and it also can inhibit edema at the inflammatory site and is analgesic | |||
T2732 | (-)-Epicatechin gallate | (−)-Epicatechin 3-gallate,Epicatechin gallate,(-)-Epicatechin 3-gallate,(-)-Epicatechin 3-O-gallate,ECG | Virus Protease , COX , Autophagy |
(-)-Epicatechin gallate ((-)-Epicatechin 3-O-gallate) is one of the catechin isomers and a potent antioxidant that can modulate a wide range of membrane proteins. Its bilayer-modifying potency was tested using gramicidin... | |||
TN2330 | Phenethyl ferulate | Caffeic Acid 3-Methyl Phenethyl Ester | Lipoxygenase , COX |
Phenethyl ferulate (Caffeic Acid 3-Methyl Phenethyl Ester) has chemopreventive properties against chemically induced colon carcinogenesis. It enhances apoptosis in azoxymethane induced colon tumors. It shows inhibitory a... | |||
T3918 | Ginsenoside Rb3 | Gypenoside IV | NF-κB , COX , NO Synthase |
Ginsenoside Rb3 (Gypenoside IV) is a natural triterpenoid saponin, exhibiting inhibition effect on TNFα-induced NF-κB transcriptional activity. It also inhibits the induction of COX-2 and iNOS mRNA. | |||
T60992 | COX-1/2-IN-3 | ||
COX-1/2-IN-3 (Compound 7a) is a dual inhibitor of COX-1 and COX-2. COX-1/2-IN-3 has anti-inflammatory activity with low toxicity [1]. | |||
T61352 | COX-2/5-LOX-IN-3 | ||
COX-2/5-LOX-IN-3 (compound 5b) is a powerful and dual inhibitor of COX-2 and 5-LOX, with IC50 values of 45.73 μM, 5.45 μM, and 4.33 μM for COX-1, COX-2, and 5-LOX, respectively. This compound, COX-2/5-LOX-IN-3, shows pro... | |||
T16328 | Nitroaspirin | NCX 4016 | Apoptosis , COX |
Nitroaspirin (NCX 4016) is a nitric oxide donor and a nitro-derivative of Aspirin, which combines with Nitroaspirin to inhibit cyclooxygenase. Nitroaspirin induces significant induction of cell cycle arrest and apoptosis... | |||
TN1291 | 7,3',4'-Tri-O-methylluteolin | 5-Hydroxy-3',4',7-trimethoxyflavone | TNF , COX , Interleukin |
7,3',4'-Tri-O-methylluteolin (5-Hydroxy-3',4',7-trimethoxyflavone) has anti-inflammatory, antibacterial and antifungal activities, it also shows moderate antitrypanosomal activity with MIC value of 19.0 ug/ml | |||
T79361 | COX-2/15-LOX-IN-3 | Lipoxygenase | |
COX-2/15-LOX-IN-3 (compound 5k) serves as a dual inhibitor for COX-2 and 15-LOX, demonstrating inhibitory concentrations (IC50) of 0.075 μM and 1.97 μM, respectively. This compound effectively suppresses LPS-induced cell... | |||
T2S0618 | β-Elemonic Acid | 3-oxo Tirucallic Acid,Beta-Elemonic acid,3-Oxotirucallenoic Acid,Elemadienonic Acid | Apoptosis , Reactive Oxygen Species , COX |
β-Elemonic Acid (3-Oxotirucallenoic Acid) exhibits anti-inflammatory effects. Beta-Elemonic acid inhibits proliferation by inducing hypoploid cells and cell apoptosis, the anticancer effects of beta-Elemonic acid are rel... | |||
T8656 | CAY10404 | 3-(4-METHYLSULPHONYLPHENYL)-4-PHENYL-5-T | Apoptosis , Akt , COX |
CAY10404 (3-(4-METHYLSULPHONYLPHENYL)-4-PHENYL-5-T) is a potent and highly selective inhibitor of COX-2 and COX-1. It is also a potent inhibitor of PKB/Akt and MAPK signalling pathways and induces apoptosis in NSC-LC cel... | |||
T8505 | SC-236 | Sc 236 | Apoptosis , COX , PPAR |
SC-236 (Sc 236) is an orally active and selective inhibitor of COX-2 (IC50 of 0.005 μM and 17.8 μM for COX-2 and COX-1, respectively). | |||
T3342 | Xanthohumol | Apoptosis , Others , Influenza Virus , COX , Acyltransferase , HSV | |
Xanthohumol, also known as 2', 4, 4'-trihydroxy-6'-methoxy-3'-prenylchalcone or desmethylxanthohumol, is a member of the class of compounds known as 3-prenylated chalcones. It inhibits COX-1 and COX-2 activity and shows ... | |||
T16950 | Sudoxicam | 4-Hydroxy-2-methyl-N-2-thiazolyl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide | COX |
Sudoxicam (4-Hydroxy-2-methyl-N-2-thiazolyl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide) is a reversible antagonist of COX with anti-inflammatory, anti-edema, and antipyretic properties. | |||
T10109 | 3-Carene | Delta-3-Carene | COX , Antifungal |
3-Carene(Delta-3-Carene) is a bicyclic monoterpene extracted from western larch and Douglas-fir that acts as a phytofungicide.3-Carene inhibits inflammatory infiltrates and COX-2 overexpression induced by nociceptive sti... | |||
T6S2023 | Harpagoside | Others , COX , NO Synthase | |
1. Harpagoside has anti-inflammatory activity. 2. Harpagoside at 3 mM concentration, shows moderate inhibition of seed germination. 3. Harpagoside can inhibit lipopolysaccharide-induced mRNA levels and protein expression... |