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SC-58125

Catalog No. T23333 CAS 162054-19-5

Synonyms: SC 58125

SC-58125 is a selective cyclooxygenase 2 (COX-2) inhibitor, with an IC50 of 0.04 μM. SC-58125 exhibits antitumor activity in vitro and in vivo, and it also can inhibit edema at the inflammatory site and is analgesic

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SC-58125, CAS 162054-19-5

Pack Size	Availability	Price/USD
5 mg	In stock	$ 55.00
10 mg	In stock	$ 97.00
25 mg	In stock	$ 213.00
50 mg	In stock	$ 345.00
100 mg	In stock	$ 558.00
1 mL * 10 mM (in DMSO)	In stock	$ 89.00

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Purity: 99.81%

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Description	SC-58125 is a selective cyclooxygenase 2 (COX-2) inhibitor, with an IC50 of 0.04 μM. SC-58125 exhibits antitumor activity in vitro and in vivo, and it also can inhibit edema at the inflammatory site and is analgesic
Targets&IC50	COX-2:0.04 μM
In vitro	SC-58125 treatment on the growth of human colon carcinoma cells in nude mice.?Delaying treatment by 2, 4, or 7 weeks following implantation of the carcinoma cells resulted in a significant inhibition of tumor growth.?Furthermore, short-term (48 hours) treatment with SC-58125 was sufficient to attenuate tumor growth for up to 15 days.?SC-58125 treatment did not alter the rate at which cells underwent apoptosis, but did result in a delayed progression through the cell cycle at the G(2)/M transition.?Accordingly, p34(cdc2) protein levels and activity were decreased following SC-58125 treatment.SC-58125 primarily exerts a cytostatic effect in vivo, which is likely to be mediated through inhibition of progression through the G(2)/M phase of the cell cycle

Synonyms	SC 58125
Molecular Weight	384.35
Formula	C17H12F4N2O2S
CAS No.	162054-19-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 9 mg/mL (23.42 mM)

References and Literature

1. Williams C S , Sheng H , Brockman J A , et al. A Cyclooxygenase-2 Inhibitor (SC-58125) Blocks Growth of Established Human Colon Cancer Xenografts[J]. Neoplasia (New York, N.Y.), 2001, 3(5).

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Cancer Active Compound Library Neuronal Signaling Compound Library ReFRAME Related Library Anti-Pancreatic Cancer Compound Library Bioactive Compound Library Anti-Cancer Compound Library Mitochondria-Targeted Compound Library Anti-Cardiovascular Disease Compound Library NO PAINS Compound Library

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Keywords

SC-58125 162054-19-5 Immunology/Inflammation Neuroscience COX SC58125 Cyclooxygenase cancer SC 58125 Inhibitor inflammatory antitumor COX-2 edema inhibit inhibitor

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