als — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T29909	ALS-I	ALS1,Acid-Liable Surfactant-1,ALS 1,ALS-1
	ALS-1 is an acid-Liable surfactant.
T14336	Allitinib	AST-1306,ALS 1306	EGFR
	Allitinib (AST-1306) (AST-1306) has anti-cancer activity，and it is an irreversible EGFR and ErbB2 inhibitor with IC50s of 0.5 and 3 nM, respectively. [1]		EGFR
T14195	ALS-8112		Others
	ALS-8112 is a inhibitor of respiratory syncytial virus (RSV) polymerase. The 5'-triphosphate form of ALS-8112 inhibits RSV polymerase (IC50: 0.02 μM).		Others
T26602	ALS-I-41
	ALS-I-41 is a novel, potent and selective antagonist of oxytocin receptor.
T2830	Betulinic acid	ALS-357,Lupatic acid,Betulic acid	Apoptosis , Mitophagy , NF-κB , HIV Protease , Topoisomerase , Endogenous Metabolite , Aminopeptidase , Autophagy
	Betulinic acid (ALS-357) is a pentacyclic lupane-type triterpene derivative of betulin (isolated from the bark of Betula alba, the common white birch) which has antiretroviral, antimalarial, and anti-inflammatory propert...
TQ0034	Lumicitabine	ALS-8176,ALS-008176	RSV
	Lumicitabine (ALS-008176) is an inhibitor of RSV polymerase.		RSV
T29970	AMG-222	AMG 222,ALS-2-0426 free base,ALS-2-0426,ALS-20426
	AMG-222 (ALS-2-0426, ALS-20426) is a DPP-4 inhibitor and may be used in the treatment of type 2 diabetes.
T19859	Nicosulfuron	Milagro,Accent,Motivell	Others
	Nicosulfuron (Milagro) is a pesticide that works by inhibiting the acetolactate synthase enzyme. Nicosulfuron has not been found to induce mutagenic or carcinogenic effects. Nicosulfuron is a herbicide to protect corn cr...		Others
T39924	NF-κΒ activator 2		NF-κB
	NF-κΒ Activator 2 is a potent, orally active compound that efficiently activates NF-κB with an EC50 value of 1.58 μM. By enhancing NF-κB expression and activation, it induces SOD 2 synthesis, rendering it useful for amyo...		NF-κB
T3198L	PRE-084 hydrochloride		Sigma receptor
	PRE-084 hydrochloride is a selective agonist of σ1(IC50:44 nM, in the sigma receptor assay).		Sigma receptor
T22911	β-N-methylamino-L-alanine hydrochloride	L-BMAA hydrochloride	Others
	β-N-methylamino-L-alanine hydrochloride (L-BMAA hydrochloride) is a neurotoxin produced by cyanobacteria. L-BMAA hydrochloride could cause amyotrophic lateral sclerosis (ALS) and possibly other neurodegenerative diseases...		Others
T7426	ALSTERPAULLONE		Apoptosis , GSK-3 , CDK
	Alsterpaullone is a Cyclin-Dependent Kinase Inhibitor, Mediated Toxicity in HeLa Cells Through Apoptosis-Inducing Effec		Apoptosis , GSK-3 , CDK
T0498	Salsalate	Disalicylic acid,Salicylsalicylic acid,Sasapyrine,NSC-49171	Reactive Oxygen Species , COX
	Salsalate (Sasapyrine) is an orally available salicylate and non-steroidal anti-inflammatory drug (NSAID), with anti-inflammatory, analgesic and antipyretic activities.		Reactive Oxygen Species , COX
TQ0277	Pralsetinib	Blu667	c-RET
	Pralsetinib (Blu667) (BLU-667) is a highly potent, selective RET inhibitor (IC50s: 0.4, 0.3, 0.4, 0.4, and 0.4 nM for WT RET, RET mutants V804L, V804M, M918T and CCDC6-RET fusion).		c-RET
T39350	Sebetralstat	KVD900	Others
	Sebetralstat (KVD900) is an inhibitor of plasma kallikrein and can be used in studies about metabolic diseases.		Others
T14358	Avoralstat	BCX4161	Others
	Avoralstat (BCX4161) is an oral plasma kallikrein (PKK) inhibitor. Which is used for the treatment of hereditary angioedema.		Others
T2318	Sacubitril/Valsartan	Sacubitril mixture with Valsartan,Valsartan,Sacubitril,LCZ696	Apoptosis , RAAS , Neprilysin
	Sacubitril/Valsartan (LCZ696) is an orally bioavailable, dual angiotensin II receptor and neprilysin inhibitor for the treatment of hypertension and heart failure.		Apoptosis , RAAS , Neprilysin
T6716	Valsartan	Diovan,Tareg,CGP 48933	RAAS
	Valsartan (CGP 48933) is a tetrazole derivative and angiotensin II type 1 receptor blocker that is used to treat hypertension.		RAAS
T17216	Valspodar	PSC 833	P-gp
	Valspodar (PSC 833) is a specific P-glycoprotein inhibitor and MDR regulator often used as a chemical sensitizer to study advanced epithelial ovarian cancer.		P-gp
T67848	Valsartan Methyl Ester		RAAS
	Valsartan Methyl Ester is a potent angiotensin II receptor antagonist, IC50= 0.06uM.		RAAS