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Lumicitabine

Name: Lumicitabine
Brand: TargetMol
SKU: TQ0034
Rating: 4.5 (1 reviews)

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Catalog No. TQ0034Cas No. 1445385-02-3

Alias ALS-8176, ALS-008176

Lumicitabine (ALS-008176) is an RSV polymerase inhibitor.

Lumicitabine

😃Good

Catalog No. TQ0034Alias ALS-8176, ALS-008176Cas No. 1445385-02-3

Lumicitabine (ALS-008176) is an RSV polymerase inhibitor.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$347	7-10 days	7-10 days
10 mg	$541	7-10 days	7-10 days
1 mL x 10 mM (in DMSO)	$329	7-10 days	7-10 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	Lumicitabine (ALS-008176) is an RSV polymerase inhibitor.
In vivo	In an adult human challenge study, Lumicitabine has shown efficacy against RSV infection[1]. Lumicitabine solubility is adequate to support oral administration in solutions with a relatively low percentage of organic solvent and in aqueous suspensions. High levels of NMP and NTP are obtained following the oral administration of Lumicitabine to monkeys [2].
Animal Research	Rats: Lumicitabine is formulated as solutions in PEG400-based vehicles. Pharmacokinetic studies are conducted at 5 mg/kg and for oral PK studies, the prodrugs are administered at 5 mg/kg parent nucleoside equivalent doses. Blood samples are typically collected at various time points up to 24 h post dose for rat [2]. Monkeys: Lumicitabine is formulated as a solution in PEG400-based vehicles. Pharmacokinetic studies are conducted at 5 mg/kg and for oral PK studies, the prodrugs are administered at 5 mg/kg parent nucleoside equivalent doses. Blood samples are typically collected at various time points up to 12 h post dose for Monkeys [2].
Synonyms	ALS-8176, ALS-008176

Chemical Properties

Molecular Weight	433.86
Formula	C₁₈H₂₅ClFN₃O₆
Cas No.	1445385-02-3
Smiles	CC(C)C(=O)OC[C@@]1(CCl)O[C@H]([C@H](F)[C@@H]1OC(=O)C(C)C)n1ccc(N)nc1=O
Relative Density.	1.43 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 48 mg/mL (110.63 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2 mg/mL (4.61 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3049 mL	11.5245 mL	23.0489 mL	115.2445 mL
5 mM	0.4610 mL	2.3049 mL	4.6098 mL	23.0489 mL
10 mM	0.2305 mL	1.1524 mL	2.3049 mL	11.5245 mL
20 mM	0.1152 mL	0.5762 mL	1.1524 mL	5.7622 mL
50 mM	0.0461 mL	0.2305 mL	0.4610 mL	2.3049 mL
100 mM	0.0230 mL	0.1152 mL	0.2305 mL	1.1524 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc