Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ALS-8112 is a inhibitor of respiratory syncytial virus (RSV) polymerase. The 5'-triphosphate form of ALS-8112 inhibits RSV polymerase (IC50: 0.02 μM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | 8-10 weeks | $ 347.00 | |
25 mg | 8-10 weeks | $ 1,140.00 | |
50 mg | 8-10 weeks | $ 1,490.00 | |
100 mg | 8-10 weeks | $ 1,990.00 | |
1 mL * 10 mM (in DMSO) | 8-10 weeks | $ 479.00 |
Description | ALS-8112 is a inhibitor of respiratory syncytial virus (RSV) polymerase. The 5'-triphosphate form of ALS-8112 inhibits RSV polymerase (IC50: 0.02 μM). |
Targets&IC50 | RSV:0.02 μM |
In vitro | ALS-8112 is a comprehensive inhibitor of RSV (respiratory syncytial virus) replication across various strains when assessed in vitro. Upon entering epithelial cells within the respiratory tract, ALS-8112 undergoes phosphorylation to produce an active nucleoside triphosphate form (ALS-8112-TP) that has a half-life of approximately 29 hours. This metabolite executes its antiviral action by terminating the extension of the viral RNA chain, effectively inhibiting RSV replication. Specifically, ALS-8112-TP targets and interferes with the RNA transcription activity of the RSV–RNP complex in a dose-dependent manner, displaying an inhibition concentration half-maximum (IC50) of 0.020 ± 0.008 μM. Thus, the 5'-triphosphate version of ALS-8112 distinctly halts the function of the RSV polymerase, leading to the cessation of RNA synthesis through chain termination, marking its specificity and efficacy as an antiviral agent against RSV. |
Molecular Weight | 293.68 |
Formula | C10H13ClFN3O4 |
CAS No. | 1445379-92-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 47 mg/mL (160.04 mM)
You can also refer to dose conversion for different animals. More
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