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Allitinib

Allitinib (AST-1306) (AST-1306) has anti-cancer activity，and it is an irreversible EGFR and ErbB2 inhibitor with IC50s of 0.5 and 3 nM, respectively. [1]

Catalog No. T14336Cas No. 897383-62-9

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Purity:99.28%

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COA HNMR HPLC

Allitinib

Catalog No. T14336Cas No. 897383-62-9

Allitinib (AST-1306) (AST-1306) has anti-cancer activity，and it is an irreversible EGFR and ErbB2 inhibitor with IC50s of 0.5 and 3 nM, respectively. [1]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Pack Size	Price	Availability
1 mg	$48	In Stock
5 mg	$113	In Stock
10 mg	$185	In Stock
25 mg	$347	In Stock
50 mg	$519	In Stock
100 mg	$737	In Stock
1 mL x 10 mM (in DMSO)	$137	In Stock

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Product Introduction

Bioactivity

Description	Allitinib (AST-1306) (AST-1306) has anti-cancer activity，and it is an irreversible EGFR and ErbB2 inhibitor with IC50s of 0.5 and 3 nM, respectively. [1]
Targets&IC50	EGFR:0.5 nM, EGFR (L858R/T790M):12 nM, ErbB2:3 nM, ERB4:0.8 nM
In vitro	AST1306 (AST-1306; 0.19-6.25 μM; 72 hours) inhibits the growth of HIH3T3-EGFR T790M/L858R cells[1]. AST1306 (0.001-1.0 μM; 4 hours) is more than 3000-fold selective for ErbB family kinases over other kinase families[1]. In A549, Calu-3, and SK-OV-3 cells, AST1306 inhibits tyrosine kinase activation and downstream signaling pathways, and dose-dependently and markedly inhibits EGF-induced EGFR phosphorylation in A549 cells[1].
In vivo	AST1306 (AST-1306; oral; 25-100 mg/kg) significantly inhibited tumor growth in SK-OV-3 and Calu-3 xenograft models[1].
Alias	AST-1306, ALS 1306

Chemical Properties

Molecular Weight	448.88
Formula	C₂₄H₁₈ClFN₄O₂
Cas No.	897383-62-9

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 55 mg/mL (122.53 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2278 mL	11.1388 mL	22.2777 mL	111.3883 mL
5 mM	0.4456 mL	2.2278 mL	4.4555 mL	22.2777 mL
10 mM	0.2228 mL	1.1139 mL	2.2278 mL	11.1388 mL
20 mM	0.1114 mL	0.5569 mL	1.1139 mL	5.5694 mL
50 mM	0.0446 mL	0.2228 mL	0.4456 mL	2.2278 mL
100 mM	0.0223 mL	0.1114 mL	0.2228 mL	1.1139 mL

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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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