acs — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T3560	Desmethylanethol trithione	ADT-OH	VEGFR , Akt
	Desmethylanethol trithione (ADT-OH) is a derivative of anethole dithiolethione (ADT) and synthetic hydrogen sulfide (H2S) donor. In the in vitro glucose-oxygen deprivation (OGD) model, Desmethylanethol trithione markedly...		VEGFR , Akt
T1284	Megestrol acetate	SC10363,BDH1298	Glucocorticoid Receptor , Estrogen/progestogen Receptor , Progesterone Receptor , HIV Protease , Autophagy
	Megestrol acetate (BDH1298) is a progestogen with actions and uses similar to those of the progestogens in general. Megestrol acetate also has anti-androgenic properties. It is given by mouth in the palliative treatment ...
T9196	IACS-13909	BBP-398	Phosphatase
	IACS-13909 (BBP-398), a specific and potent allosteric inhibitor of SHP2, that suppresses signaling through the MAPK pathway.		Phosphatase
T60060	ACSS2-IN-2	MTB-9655	Fatty Acid Synthase
	ACSS2-IN-2 (MTB-9655) is an inhibitor of acyl-CoA synthetase short-chain family member 2 (ACSS2). ACSS2-IN-2 can inhibit ACSS2 activity with an IC50 value of 3.8 nM. ACSS2-IN-2 can be used for the research of several dis...		Fatty Acid Synthase
T5337	IACS-010759	IACS-10759,IACS 10759,IACS10759	Apoptosis , Others , Mitochondrial Metabolism
	IACS-010759 is an orally bioavailable inhibitor of complex I of oxidative phosphorylation of the mitochondrial electron transport chain.		Apoptosis , Others , Mitochondrial Metabolism
T27568	IACS-010759 hydrochloride	IACS-010759 HCl,IACS-010759,IACS10759,IACS-10759,IACS 10759
	IACS-010759 is a potent inhibitor of complex I of OXPHOS with orally bioavailable. IACS-10759 effectively inhibits ATP production and oxygen consumption in isolated mitochondria, and inhibits the conversion of NADH to NA...
T69759	IACS-9439		c-Fms
	IACS-9439 is a potent, selective, and orally active inhibitor of CSF1R, exhibiting a K(i) of 1 nM. It is applicable in the research of advanced solid tumors [1].		c-Fms
T11595	IACS-8779		Others
	IACS-8779 is a potent STING agonist that efficiently stimulates interferon gene activity and exhibits strong systemic antitumor effects.		Others
T73939	IACS-8803 diammonium
	IACS-8803 diammonium, a potent cyclic dinucleotide STING agonist, demonstrates robust systemic antitumor efficacy [1].
T73938	IACS-8803 disodium
	IACS-8803 Disodium, a potent cyclic dinucleotide STING agonist, exhibits strong systemic antitumor efficacy [1].
T11627	IACS-8968 R-enantiomer	IDO/TDO Inhibitor (R-enantiomer)	IDO
	IACS-8968 R-enantiomer is the R-enantiomer of IACS-8968. IACS-8968 is a dual IDO and TDO inhibitor (pIC50s: 6.43 for IDO and <5 for TDO).		IDO
T63397	ACSS2-IN-1
	ACSS2-IN-1 is a potent inhibitor of ACSS2, capable of inhibiting ACSS2 activity with IC50 values ranging from 0.01 nM to <1 nM, and can be used in cancer research.
T27289	Etacstil	GW 5638,GW-5638,GW5638,DPC974,DPC 974,DPC-974
	GW5638 is a estrogen receptor ligand. GW5638 is a prodrug of its active metabolite GW7604. GW5638 appears to act as an antagonist in these in vitro systems, although in a manner distinct from other known ER modulators. G...
T11596	IACS-8803		Others
	IACS-8803 is a potent cyclic dinucleotide STING agonist that exhibits strong systemic antitumor efficacy.		Others
T11544	HDACs/mTOR Inhibitor 1		HDAC
	HDACs/mTOR Inhibitor 1 is a dual HDACs and mammalian target of Rapamycin (mTOR) target inhibitor for treating hematologic malignancies (IC50s: 0.19 nM, 1.8 nM, 1.2 nM, and >500 nM for HDAC1, HDAC6, mTOR and PI3Kα).		HDAC
T13199	Triacsin C	WS 1228A,FR 900190	Others
	Triacsin C, from Streptomyces aureofaciens, is a natural intracellular long-chain inhibitor of acyl-CoA synthetases (ACSL).		Others
T11628	IACS-8968 S-enantiomer	IDO/TDO Inhibitor (S-enantiomer)	IDO
	IACS-8968 S-enantiomer is the S-enantiomer of IACS-8968. IACS-8968 is a dual IDO and TDO inhibitor (pIC50s: 6.43 for IDO and <5 for TDO).		IDO
T70091	IACS-4759
	IACS-4759 is a novel potent and selective MTH1 inhibitor with excellent cell permeability and good metabolic stability in microsomes.
T78566	GlcNAcstatin
	GlcNAcstatin, a selective glucoimidazole-based inhibitor of bacterial O-GlcNAcase, exhibits a K_i value of 4.6 pM and demonstrates a specificity that is 100,000-fold greater than that for HexA/B [1].
T11597	IACS-9571	ASIS-P040	Epigenetic Reader Domain
	IACS-9571 is a selective and potent inhibitor of TRIM24 and BRPF1, (IC50: 8 nM for TRIM24; Kds: 31 nM and 14 nM for TRIM24 and BRPF1).		Epigenetic Reader Domain