Powder: -20°C for 3 years | In solvent: -80°C for 1 year
IACS-8779 is a potent STING agonist that efficiently stimulates interferon gene activity and exhibits strong systemic antitumor effects.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 10-14 weeks | $ 3,920.00 | |
50 mg | 10-14 weeks | $ 5,180.00 | |
100 mg | 10-14 weeks | $ 7,300.00 |
Description | IACS-8779 is a potent STING agonist that efficiently stimulates interferon gene activity and exhibits strong systemic antitumor effects. |
In vivo | Mice bilaterally implanted with B16-Ova tumors received intra-tumoral injections of IACS-8779 (compound 1a) at a 10 μg dose solely on one flank at intervals of three days, specifically on days 6, 9, and 12 post-implantation. While IACS-8779 demonstrated comparable antitumor efficacy on the treated flank, it elicited superior tumor regression on the untreated, contralateral flank. This indicates a stronger systemic immune response by IACS-8779 than that achieved by benchmark analogs. Furthermore, treatment with IACS-8779 resulted in a higher rate of mice being cured of tumors on both flanks, surpassing the outcomes observed with benchmark treatments. |
Molecular Weight | 689.55 |
Formula | C21H25N9O10P2S2 |
CAS No. | 2243079-26-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
IACS-8779 2243079-26-5 Others IACS8779 IACS 8779 inhibitor inhibit