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IACS-9571

Catalog No. T11597 CAS 1800477-30-8

Synonyms: ASIS-P040

IACS-9571 is a selective and potent inhibitor of TRIM24 and BRPF1, (IC50: 8 nM for TRIM24; Kds: 31 nM and 14 nM for TRIM24 and BRPF1).

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IACS-9571, CAS 1800477-30-8

Pack Size	Availability	Price/USD
5 mg	8-10 weeks	$ 1,070.00
50 mg	8-10 weeks	$ 2,180.00
100 mg	8-10 weeks	$ 2,800.00

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	IACS-9571 is a selective and potent inhibitor of TRIM24 and BRPF1, (IC50: 8 nM for TRIM24; Kds: 31 nM and 14 nM for TRIM24 and BRPF1).
Targets&IC50	BRPF1:14 nM , TRIM24:(kd)31 nM , TRIM24:8 nM
In vitro	IACS-9571 is a selective dual TRIM24/BRPF1 inhibitor (Kd = 1.3/2.1 nM) with 9- and 21-fold selectivity against BRPF2 and BRPF3, respectively. IACS-9571 does not interact with the BET sub-family of bromodomains, displaying greater than 7,700-fold selectivity versus BRD4(1, 2) relative to TRIM24.IACS-9571 shows excellent cellular potency with EC50 of 50 nM.?IACS-9571 (1 μM) has potent activities against a panel of 32 bromodomains.

Synonyms	ASIS-P040
Molecular Weight	642.76
Formula	C32H42N4O8S
CAS No.	1800477-30-8

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Palmer WS, et al. Structure-Guided Design of IACS-9571, a Selective High-Affinity Dual TRIM24-BRPF1 Bromodomain Inhibitor. J Med Chem. 2016 Feb 25;59(4):1440-54.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

IACS-9571 1800477-30-8 Chromatin/Epigenetic Epigenetic Reader Domain IACS 9571 IACS9571 ASIS-P040 Inhibitor inhibitor inhibit

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